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FeNH4(SO4)2·12H2O (alum)-catalyzed preparation of 1,4-dihydropyridines: improved conditions for the Hantzsch reaction.
Bottom Line:
FeNH4(SO4)2·12H2O (alum) efficiently catalyzes the one-pot three-component reaction of dimedone, aldehydes, and 3-aminocrotonate to afford 1,4-dihydropyridines.The work-up is easy, and the products are obtained in good to excellent yields and high purity.
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PubMed Central - PubMed
Affiliation: Department of Chemistry, Sabzevar Branch, Islamic Azad University, Sabzevar, Iran.
ABSTRACT
Abstract: FeNH4(SO4)2·12H2O (alum) efficiently catalyzes the one-pot three-component reaction of dimedone, aldehydes, and 3-aminocrotonate to afford 1,4-dihydropyridines. The work-up is easy, and the products are obtained in good to excellent yields and high purity. No MeSH data available. |
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Sch1: Mentions: In continuation of our ongoing work on multi-component reactions (MCRs) [13–16], we now wish to report a facile and rapid one-pot three component reaction for preparation of DHP derivatives 4a–4k from dimedone 1, aldehydes 2a–2k, and 3-aminocrotonates 3a, 3b using non-toxic and readily available FeNH4(SO4)2·12H2O as heterogeneous catalyst (Scheme 1). |
View Article: PubMed Central - PubMed
Affiliation: Department of Chemistry, Sabzevar Branch, Islamic Azad University, Sabzevar, Iran.
Abstract: FeNH4(SO4)2·12H2O (alum) efficiently catalyzes the one-pot three-component reaction of dimedone, aldehydes, and 3-aminocrotonate to afford 1,4-dihydropyridines. The work-up is easy, and the products are obtained in good to excellent yields and high purity.
No MeSH data available.
