Limits...
The Association between Newborn Regional Body Composition and Cord Blood Concentrations of C-Peptide and Insulin-Like Growth Factor I.

Carlsen EM, Renault KM, Jensen RB, Nørgaard K, Jensen JE, Nilas L, Cortes D, Michaelsen KF, Pryds O - PLoS ONE (2015)

Bottom Line: Prenatal exposures including maternal obesity and high gestational weight gain as well as high birth weight have been linked to subsequent metabolic disease.Arm and leg fat mass was associated with IGF-I concentration: 28 g [95% confidence interval: 4, 53] per doubling of IGF-I.There was no association between total or abdominal fat mass and IGF-I.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Hvidovre University Hospital, University of Copenhagen, Hvidovre, Denmark.

ABSTRACT

Background: Third trimester fetal growth is partially regulated by C-peptide and insulin-like growth factor I (IGF-I). Prenatal exposures including maternal obesity and high gestational weight gain as well as high birth weight have been linked to subsequent metabolic disease. We evaluated the associations between newborn regional body composition and cord blood levels of C-peptide and IGF-I.

Methods: We prospectively included obese and normal-weight mothers and their newborns; cord blood was collected and frozen. Analyses of C-peptide and IGF-I were performed simultaneously, after recruitment was completed. Newborn regional body composition was assessed with dual-energy X-ray absorptiometry scanning (DXA) within 48 hours of birth.

Results: Three hundred thirty-six term infants were eligible to participate in the study; of whom 174 (52%) infants had cord blood taken. Total, abdominal and arm and leg fat mass were positively associated with C-peptide (p < 0.001). Arm and leg fat mass was associated with IGF-I concentration: 28 g [95% confidence interval: 4, 53] per doubling of IGF-I. There was no association between total or abdominal fat mass and IGF-I. Fat-free mass was positively associated with both C-peptide (p < 0.001) and IGF-I (p = 0.004).

Conclusion: Peripheral fat tissue accumulation was associated with cord blood C-peptide and IGF-I. Total and abdominal fat masses were related to C-peptide but not to IGF-I. Thus, newborn adiposity is partially mediated through C-peptide and early linear growth is associated with IGF-I.

No MeSH data available.


Related in: MedlinePlus

Study inclusion pre-pregnancy normal weight women.When too little cord blood was obtained, it was not possible to analyze C-peptide and IGF-I.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4495032&req=5

pone.0121350.g002: Study inclusion pre-pregnancy normal weight women.When too little cord blood was obtained, it was not possible to analyze C-peptide and IGF-I.

Mentions: In total 336 were eligible for inclusion and of these 174 (52%) were included and had cord blood samples taken (Figs 1 and 2).


The Association between Newborn Regional Body Composition and Cord Blood Concentrations of C-Peptide and Insulin-Like Growth Factor I.

Carlsen EM, Renault KM, Jensen RB, Nørgaard K, Jensen JE, Nilas L, Cortes D, Michaelsen KF, Pryds O - PLoS ONE (2015)

Study inclusion pre-pregnancy normal weight women.When too little cord blood was obtained, it was not possible to analyze C-peptide and IGF-I.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495032&req=5

pone.0121350.g002: Study inclusion pre-pregnancy normal weight women.When too little cord blood was obtained, it was not possible to analyze C-peptide and IGF-I.
Mentions: In total 336 were eligible for inclusion and of these 174 (52%) were included and had cord blood samples taken (Figs 1 and 2).

Bottom Line: Prenatal exposures including maternal obesity and high gestational weight gain as well as high birth weight have been linked to subsequent metabolic disease.Arm and leg fat mass was associated with IGF-I concentration: 28 g [95% confidence interval: 4, 53] per doubling of IGF-I.There was no association between total or abdominal fat mass and IGF-I.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Hvidovre University Hospital, University of Copenhagen, Hvidovre, Denmark.

ABSTRACT

Background: Third trimester fetal growth is partially regulated by C-peptide and insulin-like growth factor I (IGF-I). Prenatal exposures including maternal obesity and high gestational weight gain as well as high birth weight have been linked to subsequent metabolic disease. We evaluated the associations between newborn regional body composition and cord blood levels of C-peptide and IGF-I.

Methods: We prospectively included obese and normal-weight mothers and their newborns; cord blood was collected and frozen. Analyses of C-peptide and IGF-I were performed simultaneously, after recruitment was completed. Newborn regional body composition was assessed with dual-energy X-ray absorptiometry scanning (DXA) within 48 hours of birth.

Results: Three hundred thirty-six term infants were eligible to participate in the study; of whom 174 (52%) infants had cord blood taken. Total, abdominal and arm and leg fat mass were positively associated with C-peptide (p < 0.001). Arm and leg fat mass was associated with IGF-I concentration: 28 g [95% confidence interval: 4, 53] per doubling of IGF-I. There was no association between total or abdominal fat mass and IGF-I. Fat-free mass was positively associated with both C-peptide (p < 0.001) and IGF-I (p = 0.004).

Conclusion: Peripheral fat tissue accumulation was associated with cord blood C-peptide and IGF-I. Total and abdominal fat masses were related to C-peptide but not to IGF-I. Thus, newborn adiposity is partially mediated through C-peptide and early linear growth is associated with IGF-I.

No MeSH data available.


Related in: MedlinePlus