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SBA-15 Mesoporous Silica Modified with Gallic Acid and Evaluation of Its Cytotoxic Activity.

Lewandowski D, Ruszkowski P, Pińska A, Schroeder G, Kurczewska J - PLoS ONE (2015)

Bottom Line: Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers.Cytotoxic activity of the hybrid organic-inorganic systems against HeLa and KB cell lines has been analyzed.Up to 67% of HeLa or KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg mL(-1)).

View Article: PubMed Central - PubMed

Affiliation: Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.

ABSTRACT
Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers. Cytotoxic activity of the hybrid organic-inorganic systems against HeLa and KB cell lines has been analyzed. Up to 67% of HeLa or KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg mL(-1)).

No MeSH data available.


Related in: MedlinePlus

Schematic representation of the procedure used for the synthesis of gallic acid modified SBA-15 mesoporous silica.
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pone.0132541.g002: Schematic representation of the procedure used for the synthesis of gallic acid modified SBA-15 mesoporous silica.

Mentions: In all procedures, the last step was the deprotection of acetyl groups. The procedure was adapted from Corey et al. [25] and carried out as follows: the modified silica sample was suspended in a saturated methanolic solution of K2CO3 and stirred at room temperature for 15 min (Fig 2). All final products changed colour during this step, starting with white, through pale pink ending with light brown. The solids were then filtered off, washed carefully with methanol and water, and dried. The presence of free phenol–OH groups could be quickly confirmed by suspending particles in a Fe3+ solution (which is slightly acidic). Deprotected products immediately formed dark violet complexes with Fe3+ ions, while the silica with acetyl-blocked phenol groups became violet after at least 5–10 min.


SBA-15 Mesoporous Silica Modified with Gallic Acid and Evaluation of Its Cytotoxic Activity.

Lewandowski D, Ruszkowski P, Pińska A, Schroeder G, Kurczewska J - PLoS ONE (2015)

Schematic representation of the procedure used for the synthesis of gallic acid modified SBA-15 mesoporous silica.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495030&req=5

pone.0132541.g002: Schematic representation of the procedure used for the synthesis of gallic acid modified SBA-15 mesoporous silica.
Mentions: In all procedures, the last step was the deprotection of acetyl groups. The procedure was adapted from Corey et al. [25] and carried out as follows: the modified silica sample was suspended in a saturated methanolic solution of K2CO3 and stirred at room temperature for 15 min (Fig 2). All final products changed colour during this step, starting with white, through pale pink ending with light brown. The solids were then filtered off, washed carefully with methanol and water, and dried. The presence of free phenol–OH groups could be quickly confirmed by suspending particles in a Fe3+ solution (which is slightly acidic). Deprotected products immediately formed dark violet complexes with Fe3+ ions, while the silica with acetyl-blocked phenol groups became violet after at least 5–10 min.

Bottom Line: Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers.Cytotoxic activity of the hybrid organic-inorganic systems against HeLa and KB cell lines has been analyzed.Up to 67% of HeLa or KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg mL(-1)).

View Article: PubMed Central - PubMed

Affiliation: Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.

ABSTRACT
Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers. Cytotoxic activity of the hybrid organic-inorganic systems against HeLa and KB cell lines has been analyzed. Up to 67% of HeLa or KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg mL(-1)).

No MeSH data available.


Related in: MedlinePlus