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SBA-15 Mesoporous Silica Modified with Gallic Acid and Evaluation of Its Cytotoxic Activity.

Lewandowski D, Ruszkowski P, Pińska A, Schroeder G, Kurczewska J - PLoS ONE (2015)

Bottom Line: Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers.Cytotoxic activity of the hybrid organic-inorganic systems against HeLa and KB cell lines has been analyzed.Up to 67% of HeLa or KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg mL(-1)).

View Article: PubMed Central - PubMed

Affiliation: Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.

ABSTRACT
Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers. Cytotoxic activity of the hybrid organic-inorganic systems against HeLa and KB cell lines has been analyzed. Up to 67% of HeLa or KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg mL(-1)).

No MeSH data available.


Related in: MedlinePlus

Modifications of gallic acid enabling its introduction onto the silica surface.
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pone.0132541.g001: Modifications of gallic acid enabling its introduction onto the silica surface.

Mentions: Acetylated gallic acid was converted into its acyl chloride each time before the immobilization on the surface. The procedure was as follows: tri-O-acetylgallic acid was dissolved in a small amount (a few ml) of dichloromethane and then large excess of thionyl chloride (~40 eq) was added, followed by catalytic amounts of dimethylformamide. The mixture was refluxed for 2 h and then volatiles were evacuated in vacuo (Fig 1). Residual amounts of unreacted thionyl chloride were removed by co-evaporation with toluene. Remaining solid was dissolved in toluene and all toluene-insoluble impurities were eliminated by filtration.The final product was obtained as white, crystalline solid with almost (>95%) quantitative yield.


SBA-15 Mesoporous Silica Modified with Gallic Acid and Evaluation of Its Cytotoxic Activity.

Lewandowski D, Ruszkowski P, Pińska A, Schroeder G, Kurczewska J - PLoS ONE (2015)

Modifications of gallic acid enabling its introduction onto the silica surface.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495030&req=5

pone.0132541.g001: Modifications of gallic acid enabling its introduction onto the silica surface.
Mentions: Acetylated gallic acid was converted into its acyl chloride each time before the immobilization on the surface. The procedure was as follows: tri-O-acetylgallic acid was dissolved in a small amount (a few ml) of dichloromethane and then large excess of thionyl chloride (~40 eq) was added, followed by catalytic amounts of dimethylformamide. The mixture was refluxed for 2 h and then volatiles were evacuated in vacuo (Fig 1). Residual amounts of unreacted thionyl chloride were removed by co-evaporation with toluene. Remaining solid was dissolved in toluene and all toluene-insoluble impurities were eliminated by filtration.The final product was obtained as white, crystalline solid with almost (>95%) quantitative yield.

Bottom Line: Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers.Cytotoxic activity of the hybrid organic-inorganic systems against HeLa and KB cell lines has been analyzed.Up to 67% of HeLa or KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg mL(-1)).

View Article: PubMed Central - PubMed

Affiliation: Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.

ABSTRACT
Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers. Cytotoxic activity of the hybrid organic-inorganic systems against HeLa and KB cell lines has been analyzed. Up to 67% of HeLa or KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg mL(-1)).

No MeSH data available.


Related in: MedlinePlus