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Differences in breast cancer characteristics and outcomes between Caucasian and Chinese women in the US.

Chen DN, Song CG, Ouyang QW, Jiang YZ, Ye FG, Ma FJ, Luo RC, Shao ZM - Oncotarget (2015)

Bottom Line: Other tumor characteristics were similarly distributed between the two races.Our analysis suggested that US-residing Chinese patients had significant differences in age, family income, marital status and area of residence, compared with their Caucasian counterparts.No significant disparities were noted in BCSS between the two races, whereas the Chinese patients had a significantly better OS.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, China.

ABSTRACT
Chinese breast cancer patients living in the United States (US) can experience different disease patterns than Caucasians, which might allow for predicting the future epidemiology of breast cancer in China. We aimed to compare the clinicopathologic characteristics and outcomes of Caucasian and Chinese female breast cancer patients residing in the US. The study cohort consisted of 3868 Chinese and 208621 Caucasian women (diagnosed from 1990 to 2009) in the US Surveillance, Epidemiology, and End Results (SEER) database. Compared with the Caucasian patients, the US-residing Chinese patients had a younger age at diagnosis and a higher family income, remained married longer, and more frequently lived in metropolitan areas. Other tumor characteristics were similarly distributed between the two races. Compared with the Caucasians, the Chinese patients had a significantly improved overall survival (OS) but similar breast cancer-specific survival (BCSS). Our analysis suggested that US-residing Chinese patients had significant differences in age, family income, marital status and area of residence, compared with their Caucasian counterparts. No significant disparities were noted in BCSS between the two races, whereas the Chinese patients had a significantly better OS. These findings warrant further investigation and should be considered in the screening and treatment of breast cancer.

No MeSH data available.


Related in: MedlinePlus

Kaplan–Meier estimates of breast cancer-specific survival (BCSS, a) and overall survival (OS, b) between Caucasian and Chinese female breast cancer patients residing in the US
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Figure 1: Kaplan–Meier estimates of breast cancer-specific survival (BCSS, a) and overall survival (OS, b) between Caucasian and Chinese female breast cancer patients residing in the US

Mentions: We first analyzed the unadjusted breast cancer-specific survival (BCSS) and overall survival (OS) rates of the Caucasian and Chinese patients using the Kaplan-Meier method and log-rank test (Figure 1). Compared to the Caucasians, the Chinese patients had significantly better OS rates (P < 0.01) but similar BCSS rates (P=0.13).


Differences in breast cancer characteristics and outcomes between Caucasian and Chinese women in the US.

Chen DN, Song CG, Ouyang QW, Jiang YZ, Ye FG, Ma FJ, Luo RC, Shao ZM - Oncotarget (2015)

Kaplan–Meier estimates of breast cancer-specific survival (BCSS, a) and overall survival (OS, b) between Caucasian and Chinese female breast cancer patients residing in the US
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494973&req=5

Figure 1: Kaplan–Meier estimates of breast cancer-specific survival (BCSS, a) and overall survival (OS, b) between Caucasian and Chinese female breast cancer patients residing in the US
Mentions: We first analyzed the unadjusted breast cancer-specific survival (BCSS) and overall survival (OS) rates of the Caucasian and Chinese patients using the Kaplan-Meier method and log-rank test (Figure 1). Compared to the Caucasians, the Chinese patients had significantly better OS rates (P < 0.01) but similar BCSS rates (P=0.13).

Bottom Line: Other tumor characteristics were similarly distributed between the two races.Our analysis suggested that US-residing Chinese patients had significant differences in age, family income, marital status and area of residence, compared with their Caucasian counterparts.No significant disparities were noted in BCSS between the two races, whereas the Chinese patients had a significantly better OS.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, China.

ABSTRACT
Chinese breast cancer patients living in the United States (US) can experience different disease patterns than Caucasians, which might allow for predicting the future epidemiology of breast cancer in China. We aimed to compare the clinicopathologic characteristics and outcomes of Caucasian and Chinese female breast cancer patients residing in the US. The study cohort consisted of 3868 Chinese and 208621 Caucasian women (diagnosed from 1990 to 2009) in the US Surveillance, Epidemiology, and End Results (SEER) database. Compared with the Caucasian patients, the US-residing Chinese patients had a younger age at diagnosis and a higher family income, remained married longer, and more frequently lived in metropolitan areas. Other tumor characteristics were similarly distributed between the two races. Compared with the Caucasians, the Chinese patients had a significantly improved overall survival (OS) but similar breast cancer-specific survival (BCSS). Our analysis suggested that US-residing Chinese patients had significant differences in age, family income, marital status and area of residence, compared with their Caucasian counterparts. No significant disparities were noted in BCSS between the two races, whereas the Chinese patients had a significantly better OS. These findings warrant further investigation and should be considered in the screening and treatment of breast cancer.

No MeSH data available.


Related in: MedlinePlus