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MAP17 (PDZKIP1) as a novel prognostic biomarker for laryngeal cancer.

de Miguel-Luken MJ, Chaves-Conde M, de Miguel-Luken V, Muñoz-Galván S, López-Guerra JL, Mateos JC, Pachón J, Chinchón D, Suarez V, Carnero A - Oncotarget (2015)

Bottom Line: The tumoral behavior induced by MAP17 is associated with reactive oxygen species production in which SGLT1 seems involved.MAP17 expression is associated with overall survival (p<0.001) and laryngoesophageal dysfunction-free survival (p=0.002).Locoregional control in patients with high MAP17 showed better outcomes than those with low MAP17 (p=0.016).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Hospital Universitario Virgen del Rocío, Seville, Spain.

ABSTRACT
Larynx cancer organ preservation treatments with chemo and radiotherapy have substantially improved laryngoesophageal dysfunction-free survival. However, both of them lead to a high incidence of acute and chronic toxicities and a significant number of patients relapse. To date, there is no evidence available to establish the group of patients that may benefit from preservation approaches and clinical criteria such as primary tumor extension or pretreatment tracheotomy are not validated. MAP17 is a small non-glycosylated membrane protein overexpressed in carcinomas. The tumoral behavior induced by MAP17 is associated with reactive oxygen species production in which SGLT1 seems involved. In this study we found that the levels of MAP17 were related to clinical findings and survival in a cohort of 58 patients with larynx cancer. MAP17 expression is associated with overall survival (p<0.001) and laryngoesophageal dysfunction-free survival (p=0.002). Locoregional control in patients with high MAP17 showed better outcomes than those with low MAP17 (p=0.016). Besides, a positive correlation was observed between MAP17 expression and SGLT (p=0.022) and the combination of high levels of MAP17/SGLT also led to an increased overall survival (p=0,028). These findings suggest that MAP17, alone or in combination with SGLT1, may become a novel predictive biomarker for laryngeal carcinoma.

No MeSH data available.


Related in: MedlinePlus

p53, Ki67, p-ERK or p-AKT do not show correlation with MAP17 expression in larynx tumorsA) Representative images of p53, Ki67, p-ERK or p-AKT immunostainings are shown for larynx tumors. B) Graphs showing lack of correlation between these proliferative or antiapoptotic markers and MAP17 expression.
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Figure 2: p53, Ki67, p-ERK or p-AKT do not show correlation with MAP17 expression in larynx tumorsA) Representative images of p53, Ki67, p-ERK or p-AKT immunostainings are shown for larynx tumors. B) Graphs showing lack of correlation between these proliferative or antiapoptotic markers and MAP17 expression.

Mentions: Out of 65 samples, only 58 were analyzed for MAP17 expression, either due to technical problems or because they did not contain any tumor cellularity. Out of the 58 samples, 46 (79%) were positives for MAP17 expression (Figure 1A, B and C) and there was a trend showing higher levels of MAP17 in advanced grades of the tumor (Figure 1D), although in this case, probably due to the low number of cases, it was not statistically significant. Surrounding normal tissue did not express MAP17 or expressed very low levels. We also analyzed other markers for proliferation such as KI67 or the activated form of ERK (phosphorylated ERK, ERK-p), or apoptosis such as mutant p53 or activated AKT (phosphorylated AKT, AKT-p). Our cohort showed a percentage of samples positive for KI67, mutant p53, ERK-p or AKT-p, but these groups did not show correlation with MAP17 levels (Figure 2). However, KI67 positivity showed statistically significant correlation with OS (Table 2). No correlation of MAP17 was observed with clinical parameters such as tumor localization, smoking habit, alcohol consumption, tumoral stage, pre-treatment tracheotomy and development of acute toxicities during chemoradiotherapy.


MAP17 (PDZKIP1) as a novel prognostic biomarker for laryngeal cancer.

de Miguel-Luken MJ, Chaves-Conde M, de Miguel-Luken V, Muñoz-Galván S, López-Guerra JL, Mateos JC, Pachón J, Chinchón D, Suarez V, Carnero A - Oncotarget (2015)

p53, Ki67, p-ERK or p-AKT do not show correlation with MAP17 expression in larynx tumorsA) Representative images of p53, Ki67, p-ERK or p-AKT immunostainings are shown for larynx tumors. B) Graphs showing lack of correlation between these proliferative or antiapoptotic markers and MAP17 expression.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494962&req=5

Figure 2: p53, Ki67, p-ERK or p-AKT do not show correlation with MAP17 expression in larynx tumorsA) Representative images of p53, Ki67, p-ERK or p-AKT immunostainings are shown for larynx tumors. B) Graphs showing lack of correlation between these proliferative or antiapoptotic markers and MAP17 expression.
Mentions: Out of 65 samples, only 58 were analyzed for MAP17 expression, either due to technical problems or because they did not contain any tumor cellularity. Out of the 58 samples, 46 (79%) were positives for MAP17 expression (Figure 1A, B and C) and there was a trend showing higher levels of MAP17 in advanced grades of the tumor (Figure 1D), although in this case, probably due to the low number of cases, it was not statistically significant. Surrounding normal tissue did not express MAP17 or expressed very low levels. We also analyzed other markers for proliferation such as KI67 or the activated form of ERK (phosphorylated ERK, ERK-p), or apoptosis such as mutant p53 or activated AKT (phosphorylated AKT, AKT-p). Our cohort showed a percentage of samples positive for KI67, mutant p53, ERK-p or AKT-p, but these groups did not show correlation with MAP17 levels (Figure 2). However, KI67 positivity showed statistically significant correlation with OS (Table 2). No correlation of MAP17 was observed with clinical parameters such as tumor localization, smoking habit, alcohol consumption, tumoral stage, pre-treatment tracheotomy and development of acute toxicities during chemoradiotherapy.

Bottom Line: The tumoral behavior induced by MAP17 is associated with reactive oxygen species production in which SGLT1 seems involved.MAP17 expression is associated with overall survival (p<0.001) and laryngoesophageal dysfunction-free survival (p=0.002).Locoregional control in patients with high MAP17 showed better outcomes than those with low MAP17 (p=0.016).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Hospital Universitario Virgen del Rocío, Seville, Spain.

ABSTRACT
Larynx cancer organ preservation treatments with chemo and radiotherapy have substantially improved laryngoesophageal dysfunction-free survival. However, both of them lead to a high incidence of acute and chronic toxicities and a significant number of patients relapse. To date, there is no evidence available to establish the group of patients that may benefit from preservation approaches and clinical criteria such as primary tumor extension or pretreatment tracheotomy are not validated. MAP17 is a small non-glycosylated membrane protein overexpressed in carcinomas. The tumoral behavior induced by MAP17 is associated with reactive oxygen species production in which SGLT1 seems involved. In this study we found that the levels of MAP17 were related to clinical findings and survival in a cohort of 58 patients with larynx cancer. MAP17 expression is associated with overall survival (p<0.001) and laryngoesophageal dysfunction-free survival (p=0.002). Locoregional control in patients with high MAP17 showed better outcomes than those with low MAP17 (p=0.016). Besides, a positive correlation was observed between MAP17 expression and SGLT (p=0.022) and the combination of high levels of MAP17/SGLT also led to an increased overall survival (p=0,028). These findings suggest that MAP17, alone or in combination with SGLT1, may become a novel predictive biomarker for laryngeal carcinoma.

No MeSH data available.


Related in: MedlinePlus