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Synthesis, characterization, and tuberculostatic activity of novel 2-(4-nitrobenzoyl)hydrazinecarbodithioic acid derivatives.

Gobis K, Foks H, Augustynowicz-Kopec E, Napiorkowska A, Szczesio M, Olczak A, Glowka ML - Monatsh. Chem. (2012)

Bottom Line: Novel 5-(4-nitrophenyl)-1,3,4-oxadiazoles were also obtained.Promising preliminary results were obtained for some of the compounds.The crystal structure of the most active compound was determined.

View Article: PubMed Central - PubMed

Affiliation: Department of Organic Chemistry, Medical University of Gdansk, 107 Gen. Hallera Str., 80-416 Gdansk, Poland.

ABSTRACT

Abstract: A series of novel S-esters of 2-(4-nitrobenzoyl)hydrazinecarbodithioic acid and S,S'-diesters of (4-nitrobenzoyl)carbonohydrazonodithioic acid were synthesized by reaction of 4-nitrobenzohydrazide and N-methyl-4-nitrobenzohydrazide with carbon disulfide and alkyl halides in the presence of triethylamine. Novel 5-(4-nitrophenyl)-1,3,4-oxadiazoles were also obtained. The structures were confirmed by IR, NMR, and mass spectroscopy, and by elemental analysis. All the compounds obtained were screened in vitro for their tuberculostatic activity. Promising preliminary results were obtained for some of the compounds. The crystal structure of the most active compound was determined.

No MeSH data available.


The molecular structure of 18, showing the atom-numbering scheme. Displacement ellipsoids are drawn at the 50% probability level
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Fig3: The molecular structure of 18, showing the atom-numbering scheme. Displacement ellipsoids are drawn at the 50% probability level

Mentions: X-ray diffraction was performed for the most active 1,3,4-oxadiazole 18. Its molecular structure is shown in Fig. 3. Crystal data, details of data collections, reduction, and refinement are shown in Table 2.Fig. 3


Synthesis, characterization, and tuberculostatic activity of novel 2-(4-nitrobenzoyl)hydrazinecarbodithioic acid derivatives.

Gobis K, Foks H, Augustynowicz-Kopec E, Napiorkowska A, Szczesio M, Olczak A, Glowka ML - Monatsh. Chem. (2012)

The molecular structure of 18, showing the atom-numbering scheme. Displacement ellipsoids are drawn at the 50% probability level
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4494774&req=5

Fig3: The molecular structure of 18, showing the atom-numbering scheme. Displacement ellipsoids are drawn at the 50% probability level
Mentions: X-ray diffraction was performed for the most active 1,3,4-oxadiazole 18. Its molecular structure is shown in Fig. 3. Crystal data, details of data collections, reduction, and refinement are shown in Table 2.Fig. 3

Bottom Line: Novel 5-(4-nitrophenyl)-1,3,4-oxadiazoles were also obtained.Promising preliminary results were obtained for some of the compounds.The crystal structure of the most active compound was determined.

View Article: PubMed Central - PubMed

Affiliation: Department of Organic Chemistry, Medical University of Gdansk, 107 Gen. Hallera Str., 80-416 Gdansk, Poland.

ABSTRACT

Abstract: A series of novel S-esters of 2-(4-nitrobenzoyl)hydrazinecarbodithioic acid and S,S'-diesters of (4-nitrobenzoyl)carbonohydrazonodithioic acid were synthesized by reaction of 4-nitrobenzohydrazide and N-methyl-4-nitrobenzohydrazide with carbon disulfide and alkyl halides in the presence of triethylamine. Novel 5-(4-nitrophenyl)-1,3,4-oxadiazoles were also obtained. The structures were confirmed by IR, NMR, and mass spectroscopy, and by elemental analysis. All the compounds obtained were screened in vitro for their tuberculostatic activity. Promising preliminary results were obtained for some of the compounds. The crystal structure of the most active compound was determined.

No MeSH data available.