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Synthesis, structure, and tuberculostatic activity of dimethyl benzoylcarbonohydrazonodithioates.

Gobis K, Foks H, Zwolska Z, Augustynowicz-Kopeć E, Główka ML, Olczak A, Sabisz M - Monatsh. Chem. (2011)

Bottom Line: New dimethyl benzoylcarbonohydrazonodithioates were obtained by CS2 addition to arylcarboxylic acid hydrazides and methylation of the formed adduct.The new derivatives were tested for their activity against Mycobacterium tuberculosis.Some compounds exhibited high activity toward sensitive and resistant strains.

View Article: PubMed Central - PubMed

Affiliation: Department of Organic Chemistry, Medical University of Gdansk, Gdansk, Poland.

ABSTRACT

Abstract: New dimethyl benzoylcarbonohydrazonodithioates were obtained by CS2 addition to arylcarboxylic acid hydrazides and methylation of the formed adduct. The new derivatives were tested for their activity against Mycobacterium tuberculosis. Some compounds exhibited high activity toward sensitive and resistant strains.

No MeSH data available.


Related in: MedlinePlus

 
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Sch1:  

Mentions: The starting benzohydrazides were obtained from methyl esters in a typical reaction with 100% hydrazine hydrate. Hydrazides upon treatment with carbon disulfide and a double excess of methyl iodide in a basic environment of KOH or triethylamine were transformed into the corresponding dimethyl benzoylcarbonohydrazonodithioates 1–14 (Scheme 1).Scheme 1


Synthesis, structure, and tuberculostatic activity of dimethyl benzoylcarbonohydrazonodithioates.

Gobis K, Foks H, Zwolska Z, Augustynowicz-Kopeć E, Główka ML, Olczak A, Sabisz M - Monatsh. Chem. (2011)

 
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4494766&req=5

Sch1:  
Mentions: The starting benzohydrazides were obtained from methyl esters in a typical reaction with 100% hydrazine hydrate. Hydrazides upon treatment with carbon disulfide and a double excess of methyl iodide in a basic environment of KOH or triethylamine were transformed into the corresponding dimethyl benzoylcarbonohydrazonodithioates 1–14 (Scheme 1).Scheme 1

Bottom Line: New dimethyl benzoylcarbonohydrazonodithioates were obtained by CS2 addition to arylcarboxylic acid hydrazides and methylation of the formed adduct.The new derivatives were tested for their activity against Mycobacterium tuberculosis.Some compounds exhibited high activity toward sensitive and resistant strains.

View Article: PubMed Central - PubMed

Affiliation: Department of Organic Chemistry, Medical University of Gdansk, Gdansk, Poland.

ABSTRACT

Abstract: New dimethyl benzoylcarbonohydrazonodithioates were obtained by CS2 addition to arylcarboxylic acid hydrazides and methylation of the formed adduct. The new derivatives were tested for their activity against Mycobacterium tuberculosis. Some compounds exhibited high activity toward sensitive and resistant strains.

No MeSH data available.


Related in: MedlinePlus