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The synthesis of new potential photosensitizers. 1. Mono-carboxylic acid derivatives of tetraphenylporphyrin.

Zięba G, Rojkiewicz M, Kozik V, Jarzembek K, Jarczyk A, Sochanik A, Kuś P - Monatsh. Chem. (2011)

Bottom Line: A series of mono-alkylcarboxylic acid derivatives of tetraphenylporphyrin have been prepared.Experimental log P were determined by use of reversed-phase thin-layer chromatography with use of log P Rekker.These porphyrins are potential photosensitizers in photodynamic therapy. .

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Affiliation: Department of Chemistry, University of Silesia, 9, Szkolna Street, 40-006 Katowice, Poland.

ABSTRACT

Abstract: A series of mono-alkylcarboxylic acid derivatives of tetraphenylporphyrin have been prepared. All the porphyrins were completely characterized by use of mass, (1)H NMR, UV-visible, and fluorescence spectroscopy. Experimental log P were determined by use of reversed-phase thin-layer chromatography with use of log P Rekker. These porphyrins are potential photosensitizers in photodynamic therapy.

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No MeSH data available.


 
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Sch2:  

Mentions: Porphyrins 4 and 5 were obtained by a different method, direct reaction of a suitable ethyl ester of ω-bromoalkyl acid with hydroxyl derivative of porphyrin (Scheme 2). The esters were hydrolysed to the corresponding carboxylic derivatives.Scheme 2


The synthesis of new potential photosensitizers. 1. Mono-carboxylic acid derivatives of tetraphenylporphyrin.

Zięba G, Rojkiewicz M, Kozik V, Jarzembek K, Jarczyk A, Sochanik A, Kuś P - Monatsh. Chem. (2011)

 
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4494763&req=5

Sch2:  
Mentions: Porphyrins 4 and 5 were obtained by a different method, direct reaction of a suitable ethyl ester of ω-bromoalkyl acid with hydroxyl derivative of porphyrin (Scheme 2). The esters were hydrolysed to the corresponding carboxylic derivatives.Scheme 2

Bottom Line: A series of mono-alkylcarboxylic acid derivatives of tetraphenylporphyrin have been prepared.Experimental log P were determined by use of reversed-phase thin-layer chromatography with use of log P Rekker.These porphyrins are potential photosensitizers in photodynamic therapy. .

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Silesia, 9, Szkolna Street, 40-006 Katowice, Poland.

ABSTRACT

Abstract: A series of mono-alkylcarboxylic acid derivatives of tetraphenylporphyrin have been prepared. All the porphyrins were completely characterized by use of mass, (1)H NMR, UV-visible, and fluorescence spectroscopy. Experimental log P were determined by use of reversed-phase thin-layer chromatography with use of log P Rekker. These porphyrins are potential photosensitizers in photodynamic therapy.

Graphical abstract: .

No MeSH data available.