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Evaluation of coronary adventitial vasa vasorum using 3D optical coherence tomography--animal and human studies.

Aoki T, Rodriguez-Porcel M, Matsuo Y, Cassar A, Kwon TG, Franchi F, Gulati R, Kushwaha SS, Lennon RJ, Lerman LO, Ritman EL, Lerman A - Atherosclerosis (2015)

Bottom Line: In OCT images, adventitial MC was identified as signal-voiding areas which were located within 1 mm from the lumen-intima border.In the human study, there was a significant positive correlation between MCV and PV (segment number = 24, r(2) = 0.63, P < 0.01).Our results suggest that evaluation of MCV with 3D OCT imaging might be a novel method to estimate the amount of adventitial VV in vivo, and further has the potential to provide a pathophysiological insight into a role of the VV in allograft vasculopathy.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

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Representative coronary 3D OCT Images with MCV and PV of each segment, and correlation between %MCV and %PVA. Representative coronary 3D images obtained from a transplant recipient; right image was obtained by 180 degrees of rotation of left one. In this case, most proximal segment was not depicted because of exclusion due to poor images. Vessel lumen is depicted in red; microchannel, green.B. %MCV was significantly correlated with %PV.MCV indicates microchannel volume; PV, plaque volume.
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Figure 3: Representative coronary 3D OCT Images with MCV and PV of each segment, and correlation between %MCV and %PVA. Representative coronary 3D images obtained from a transplant recipient; right image was obtained by 180 degrees of rotation of left one. In this case, most proximal segment was not depicted because of exclusion due to poor images. Vessel lumen is depicted in red; microchannel, green.B. %MCV was significantly correlated with %PV.MCV indicates microchannel volume; PV, plaque volume.

Mentions: Representative 3D OCT image of coronary artery and the segmental MCV and PV were shown in Figure 3A. We analyzed 24 (average 3 segments per person) of 40 segments after exclusion of 16 segments; 11 segments had poor images due to incomplete blood removal, and 5 segments with major branches. We indicated the summary of the parameters among the 24 segments in Table 2. The medians value of %MCV and %PV were 1.27% [0.88, 1.59] and 19.3% [16.9, 22.5]. There were no segments with intraplaque MC and more than1 mm of vessel wall.


Evaluation of coronary adventitial vasa vasorum using 3D optical coherence tomography--animal and human studies.

Aoki T, Rodriguez-Porcel M, Matsuo Y, Cassar A, Kwon TG, Franchi F, Gulati R, Kushwaha SS, Lennon RJ, Lerman LO, Ritman EL, Lerman A - Atherosclerosis (2015)

Representative coronary 3D OCT Images with MCV and PV of each segment, and correlation between %MCV and %PVA. Representative coronary 3D images obtained from a transplant recipient; right image was obtained by 180 degrees of rotation of left one. In this case, most proximal segment was not depicted because of exclusion due to poor images. Vessel lumen is depicted in red; microchannel, green.B. %MCV was significantly correlated with %PV.MCV indicates microchannel volume; PV, plaque volume.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494669&req=5

Figure 3: Representative coronary 3D OCT Images with MCV and PV of each segment, and correlation between %MCV and %PVA. Representative coronary 3D images obtained from a transplant recipient; right image was obtained by 180 degrees of rotation of left one. In this case, most proximal segment was not depicted because of exclusion due to poor images. Vessel lumen is depicted in red; microchannel, green.B. %MCV was significantly correlated with %PV.MCV indicates microchannel volume; PV, plaque volume.
Mentions: Representative 3D OCT image of coronary artery and the segmental MCV and PV were shown in Figure 3A. We analyzed 24 (average 3 segments per person) of 40 segments after exclusion of 16 segments; 11 segments had poor images due to incomplete blood removal, and 5 segments with major branches. We indicated the summary of the parameters among the 24 segments in Table 2. The medians value of %MCV and %PV were 1.27% [0.88, 1.59] and 19.3% [16.9, 22.5]. There were no segments with intraplaque MC and more than1 mm of vessel wall.

Bottom Line: In OCT images, adventitial MC was identified as signal-voiding areas which were located within 1 mm from the lumen-intima border.In the human study, there was a significant positive correlation between MCV and PV (segment number = 24, r(2) = 0.63, P < 0.01).Our results suggest that evaluation of MCV with 3D OCT imaging might be a novel method to estimate the amount of adventitial VV in vivo, and further has the potential to provide a pathophysiological insight into a role of the VV in allograft vasculopathy.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

Show MeSH
Related in: MedlinePlus