Evaluation of coronary adventitial vasa vasorum using 3D optical coherence tomography--animal and human studies.
Bottom Line: In OCT images, adventitial MC was identified as signal-voiding areas which were located within 1 mm from the lumen-intima border.In the human study, there was a significant positive correlation between MCV and PV (segment number = 24, r(2) = 0.63, P < 0.01).Our results suggest that evaluation of MCV with 3D OCT imaging might be a novel method to estimate the amount of adventitial VV in vivo, and further has the potential to provide a pathophysiological insight into a role of the VV in allograft vasculopathy.
Affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.Show MeSH
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Mentions: Representative 3D OCT image of coronary artery and the segmental MCV and PV were shown in Figure 3A. We analyzed 24 (average 3 segments per person) of 40 segments after exclusion of 16 segments; 11 segments had poor images due to incomplete blood removal, and 5 segments with major branches. We indicated the summary of the parameters among the 24 segments in Table 2. The medians value of %MCV and %PV were 1.27% [0.88, 1.59] and 19.3% [16.9, 22.5]. There were no segments with intraplaque MC and more than1 mm of vessel wall.
Affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.