Evaluation of coronary adventitial vasa vasorum using 3D optical coherence tomography--animal and human studies.
Bottom Line: In OCT images, adventitial MC was identified as signal-voiding areas which were located within 1 mm from the lumen-intima border.In the human study, there was a significant positive correlation between MCV and PV (segment number = 24, r(2) = 0.63, P < 0.01).Our results suggest that evaluation of MCV with 3D OCT imaging might be a novel method to estimate the amount of adventitial VV in vivo, and further has the potential to provide a pathophysiological insight into a role of the VV in allograft vasculopathy.
Affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.Show MeSH
Related in: MedlinePlus
Mentions: After adjusting the segments, we were able to obtain 8 one-mm-segments corresponding in both the methods (m-CT and OCT) in each swine (total 16 segments). VV volume by m-CT was too small to match corresponding OCT images with anatomical landmark in right carotid artery. The comparison between VV volume by mCT and MCV by OCT was evaluated in the left carotid artery. The blood-injected, left carotid arteries had larger VV volume compared with the control right carotid arteries (Supplemental figure 2A). Also, MCV and arterial lumen volume of left carotid artery by OCT were significantly greater than VV and lumen volumes by m-CT (Supplemental figure 2B and 2C). With the left carotid arteries, volume and count of MC detected by OCT significantly correlated with those of VV detected by m-CT (Figure 2A and 2B).
Affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.