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Evaluation of coronary adventitial vasa vasorum using 3D optical coherence tomography--animal and human studies.

Aoki T, Rodriguez-Porcel M, Matsuo Y, Cassar A, Kwon TG, Franchi F, Gulati R, Kushwaha SS, Lennon RJ, Lerman LO, Ritman EL, Lerman A - Atherosclerosis (2015)

Bottom Line: In OCT images, adventitial MC was identified as signal-voiding areas which were located within 1 mm from the lumen-intima border.In the human study, there was a significant positive correlation between MCV and PV (segment number = 24, r(2) = 0.63, P < 0.01).Our results suggest that evaluation of MCV with 3D OCT imaging might be a novel method to estimate the amount of adventitial VV in vivo, and further has the potential to provide a pathophysiological insight into a role of the VV in allograft vasculopathy.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

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MC in OCT and VV in m-CTA. The correlations between MCV detected by OCT and VV volume detected by m-CT in the swine model are shown. MCV were significantly correlated with VV volume among 16 corresponding 1-mm-segments. B. The correlations between average counts of MC and VV significantly correlated in the each corresponding 1-mm-segment. C. Bland-Altman plot of logarithmic MC and VV count. Black solid line indicates mean difference of both the logarithmic values; black dashed lines, 95% CI; red dashed lines, limits of agreement.MC, microchannel; m-CT, micro-computerized tomography; MCV indicates microchannel volume; OCT, optical coherence tomography; VV, vasa vasorum.
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Figure 2: MC in OCT and VV in m-CTA. The correlations between MCV detected by OCT and VV volume detected by m-CT in the swine model are shown. MCV were significantly correlated with VV volume among 16 corresponding 1-mm-segments. B. The correlations between average counts of MC and VV significantly correlated in the each corresponding 1-mm-segment. C. Bland-Altman plot of logarithmic MC and VV count. Black solid line indicates mean difference of both the logarithmic values; black dashed lines, 95% CI; red dashed lines, limits of agreement.MC, microchannel; m-CT, micro-computerized tomography; MCV indicates microchannel volume; OCT, optical coherence tomography; VV, vasa vasorum.

Mentions: After adjusting the segments, we were able to obtain 8 one-mm-segments corresponding in both the methods (m-CT and OCT) in each swine (total 16 segments). VV volume by m-CT was too small to match corresponding OCT images with anatomical landmark in right carotid artery. The comparison between VV volume by mCT and MCV by OCT was evaluated in the left carotid artery. The blood-injected, left carotid arteries had larger VV volume compared with the control right carotid arteries (Supplemental figure 2A). Also, MCV and arterial lumen volume of left carotid artery by OCT were significantly greater than VV and lumen volumes by m-CT (Supplemental figure 2B and 2C). With the left carotid arteries, volume and count of MC detected by OCT significantly correlated with those of VV detected by m-CT (Figure 2A and 2B).


Evaluation of coronary adventitial vasa vasorum using 3D optical coherence tomography--animal and human studies.

Aoki T, Rodriguez-Porcel M, Matsuo Y, Cassar A, Kwon TG, Franchi F, Gulati R, Kushwaha SS, Lennon RJ, Lerman LO, Ritman EL, Lerman A - Atherosclerosis (2015)

MC in OCT and VV in m-CTA. The correlations between MCV detected by OCT and VV volume detected by m-CT in the swine model are shown. MCV were significantly correlated with VV volume among 16 corresponding 1-mm-segments. B. The correlations between average counts of MC and VV significantly correlated in the each corresponding 1-mm-segment. C. Bland-Altman plot of logarithmic MC and VV count. Black solid line indicates mean difference of both the logarithmic values; black dashed lines, 95% CI; red dashed lines, limits of agreement.MC, microchannel; m-CT, micro-computerized tomography; MCV indicates microchannel volume; OCT, optical coherence tomography; VV, vasa vasorum.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494669&req=5

Figure 2: MC in OCT and VV in m-CTA. The correlations between MCV detected by OCT and VV volume detected by m-CT in the swine model are shown. MCV were significantly correlated with VV volume among 16 corresponding 1-mm-segments. B. The correlations between average counts of MC and VV significantly correlated in the each corresponding 1-mm-segment. C. Bland-Altman plot of logarithmic MC and VV count. Black solid line indicates mean difference of both the logarithmic values; black dashed lines, 95% CI; red dashed lines, limits of agreement.MC, microchannel; m-CT, micro-computerized tomography; MCV indicates microchannel volume; OCT, optical coherence tomography; VV, vasa vasorum.
Mentions: After adjusting the segments, we were able to obtain 8 one-mm-segments corresponding in both the methods (m-CT and OCT) in each swine (total 16 segments). VV volume by m-CT was too small to match corresponding OCT images with anatomical landmark in right carotid artery. The comparison between VV volume by mCT and MCV by OCT was evaluated in the left carotid artery. The blood-injected, left carotid arteries had larger VV volume compared with the control right carotid arteries (Supplemental figure 2A). Also, MCV and arterial lumen volume of left carotid artery by OCT were significantly greater than VV and lumen volumes by m-CT (Supplemental figure 2B and 2C). With the left carotid arteries, volume and count of MC detected by OCT significantly correlated with those of VV detected by m-CT (Figure 2A and 2B).

Bottom Line: In OCT images, adventitial MC was identified as signal-voiding areas which were located within 1 mm from the lumen-intima border.In the human study, there was a significant positive correlation between MCV and PV (segment number = 24, r(2) = 0.63, P < 0.01).Our results suggest that evaluation of MCV with 3D OCT imaging might be a novel method to estimate the amount of adventitial VV in vivo, and further has the potential to provide a pathophysiological insight into a role of the VV in allograft vasculopathy.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

Show MeSH
Related in: MedlinePlus