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Adverse reaction to ceftriaxone in a 28-day-old infant undergoing urgent craniotomy due to epidural hematoma: review of neonatal biliary pseudolithiasis.

Bartkowska-Śniatkowska A, Jończyk-Potoczna K, Zielińska M, Rosada-Kurasińska J - Ther Clin Risk Manag (2015)

Bottom Line: Although pediatric patients rarely develop gallbladder disorders, this complication may lead to adverse events in high-risk patients with predisposing factors, particularly in neonates and infants treated with ceftriaxone.We also discuss the efficacy of ceftriaxone in neonates and infants.Neonatologists and pediatric intensivists should be aware of the higher risk of co-existence of hyperbilirubinemia and gallbladder disorders while using ceftriaxone in pediatric settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric Anesthesiology and Intensive Therapy, Poznan University of Medical Sciences, Poznan, Poland.

ABSTRACT
The debate as to whether to administer ceftriaxone to neonates is likely to continue. Ceftriaxone has numerous advantages for critically ill pediatric patients. However, it is also known to contribute substantially to the development of biliary pseudolithiasis. Although pediatric patients rarely develop gallbladder disorders, this complication may lead to adverse events in high-risk patients with predisposing factors, particularly in neonates and infants treated with ceftriaxone. In this paper we present an interesting case report of a 28-day-old neonate with spontaneous severe epidural hematoma who developed biliary pseudolithiasis related to the use of ceftriaxone. We also discuss the efficacy of ceftriaxone in neonates and infants. Neonatologists and pediatric intensivists should be aware of the higher risk of co-existence of hyperbilirubinemia and gallbladder disorders while using ceftriaxone in pediatric settings.

No MeSH data available.


Related in: MedlinePlus

Post craniotomy axial CT shows extensive hypodensity involving the gray and white matter of the left hemisphere with bleeding foci. Midline shift and uncal herniation is also seen.
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f1-tcrm-11-1035: Post craniotomy axial CT shows extensive hypodensity involving the gray and white matter of the left hemisphere with bleeding foci. Midline shift and uncal herniation is also seen.

Mentions: On the second day of hospital stay, the patient underwent computerized tomography of the head and ultrasound imaging of his abdomen as a routine pediatric intensive care procedure. Post-craniotomy axial computerized tomography scans revealed extensive hypodensity involving the gray as well as the white matter of the left hemisphere with bleeding foci. Midline shift and uncal herniation were also seen (Figure 1). Also the following sonographic findings were observed in the abdomen: dilation of the biliary tree, thickening of the dilated cystic duct wall, common hepatic duct, and common bile duct (Figure 2A) and mass-like sludge in the gallbladder (Figure 2B).


Adverse reaction to ceftriaxone in a 28-day-old infant undergoing urgent craniotomy due to epidural hematoma: review of neonatal biliary pseudolithiasis.

Bartkowska-Śniatkowska A, Jończyk-Potoczna K, Zielińska M, Rosada-Kurasińska J - Ther Clin Risk Manag (2015)

Post craniotomy axial CT shows extensive hypodensity involving the gray and white matter of the left hemisphere with bleeding foci. Midline shift and uncal herniation is also seen.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494631&req=5

f1-tcrm-11-1035: Post craniotomy axial CT shows extensive hypodensity involving the gray and white matter of the left hemisphere with bleeding foci. Midline shift and uncal herniation is also seen.
Mentions: On the second day of hospital stay, the patient underwent computerized tomography of the head and ultrasound imaging of his abdomen as a routine pediatric intensive care procedure. Post-craniotomy axial computerized tomography scans revealed extensive hypodensity involving the gray as well as the white matter of the left hemisphere with bleeding foci. Midline shift and uncal herniation were also seen (Figure 1). Also the following sonographic findings were observed in the abdomen: dilation of the biliary tree, thickening of the dilated cystic duct wall, common hepatic duct, and common bile duct (Figure 2A) and mass-like sludge in the gallbladder (Figure 2B).

Bottom Line: Although pediatric patients rarely develop gallbladder disorders, this complication may lead to adverse events in high-risk patients with predisposing factors, particularly in neonates and infants treated with ceftriaxone.We also discuss the efficacy of ceftriaxone in neonates and infants.Neonatologists and pediatric intensivists should be aware of the higher risk of co-existence of hyperbilirubinemia and gallbladder disorders while using ceftriaxone in pediatric settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric Anesthesiology and Intensive Therapy, Poznan University of Medical Sciences, Poznan, Poland.

ABSTRACT
The debate as to whether to administer ceftriaxone to neonates is likely to continue. Ceftriaxone has numerous advantages for critically ill pediatric patients. However, it is also known to contribute substantially to the development of biliary pseudolithiasis. Although pediatric patients rarely develop gallbladder disorders, this complication may lead to adverse events in high-risk patients with predisposing factors, particularly in neonates and infants treated with ceftriaxone. In this paper we present an interesting case report of a 28-day-old neonate with spontaneous severe epidural hematoma who developed biliary pseudolithiasis related to the use of ceftriaxone. We also discuss the efficacy of ceftriaxone in neonates and infants. Neonatologists and pediatric intensivists should be aware of the higher risk of co-existence of hyperbilirubinemia and gallbladder disorders while using ceftriaxone in pediatric settings.

No MeSH data available.


Related in: MedlinePlus