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Cytochrome P450 1A1 exon 7 polymorphism and susceptibility to lung cancer in the Chinese population: an updated meta-analysis and review.

Wei XP, Hu J - Onco Targets Ther (2015)

Bottom Line: To clarify the effects of CYP1A1 exon 7 polymorphism on the risk of LC, an updated meta-analysis was performed in the Chinese population.Overall, significant association was found between CYP1A1 exon 7 polymorphism and LC risk when all studies in the Chinese population were pooled into this meta-analysis (GG versus AA: OR = 1.71, 95% CI: 1.46-2.01; GG versus AG: OR = 1.41, 95% CI: 1.21-1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16-1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32-1.76).In subgroup analyses stratified by ethnicity, source of controls, and geographical locations, significantly increased risk was found in Chinese Han people, in population-based studies, in hospital-based studies, in South China, and in North China.

View Article: PubMed Central - PubMed

Affiliation: Respiratory Department, Beijing Tiantan Hospital affiliated to Capital Medical University, Beijing, People's Republic of China.

ABSTRACT

Background: Although many epidemiologic studies have investigated the cytochrome P450 1A1 (CYP1A1) exon 7 gene polymorphism and its association with lung cancer (LC), definitive conclusions cannot be drawn.

Objective: To clarify the effects of CYP1A1 exon 7 polymorphism on the risk of LC, an updated meta-analysis was performed in the Chinese population.

Methods: Related studies were identified from PubMed, Springer Link, Ovid, the Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biology Medicine (CBM) databases until October 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations.

Results: A total of 25 articles including 3,540 LC cases and 5,284 controls were included in this meta-analysis. Overall, significant association was found between CYP1A1 exon 7 polymorphism and LC risk when all studies in the Chinese population were pooled into this meta-analysis (GG versus AA: OR = 1.71, 95% CI: 1.46-2.01; GG versus AG: OR = 1.41, 95% CI: 1.21-1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16-1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32-1.76). In subgroup analyses stratified by ethnicity, source of controls, and geographical locations, significantly increased risk was found in Chinese Han people, in population-based studies, in hospital-based studies, in South China, and in North China.

Conclusion: This meta-analysis provides the evidence that CYP1A1 exon 7 polymorphism may contribute to LC development in the Chinese population, and studies with a larger sample size and wider population spectrum are warranted to verify this finding.

No MeSH data available.


Related in: MedlinePlus

Publication bias assessment of CYP1A1 MspI polymorphism and lung cancer risk under the allele genetic model.Notes: (A) Begg’s funnel plot. (B) Egger’s test.Abbreviation: SE, standard error.
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f3-ott-8-1611: Publication bias assessment of CYP1A1 MspI polymorphism and lung cancer risk under the allele genetic model.Notes: (A) Begg’s funnel plot. (B) Egger’s test.Abbreviation: SE, standard error.

Mentions: In order to compare the difference and evaluate the sensitivity of the meta-analysis, we used both models (fixed-effects and random-effects) to evaluate the stability of the meta-analysis. None of the results were materially altered (Table 2). Hence, the results of the sensitivity analysis suggest that the data in this meta-analysis are relatively stable and credible. Begg’s funnel plot and Egger’s test were performed to assess publication bias. The shape of the funnel plots did not reveal obvious asymmetry (Figure 3A). Subsequently, the Egger’s test was used to provide statistical evidence of funnel plot symmetry. The Egger’s test indicated that there was no obvious publication bias under the allele model in overall analysis (Figure 3B) (t=2.09, P=0.058).


Cytochrome P450 1A1 exon 7 polymorphism and susceptibility to lung cancer in the Chinese population: an updated meta-analysis and review.

Wei XP, Hu J - Onco Targets Ther (2015)

Publication bias assessment of CYP1A1 MspI polymorphism and lung cancer risk under the allele genetic model.Notes: (A) Begg’s funnel plot. (B) Egger’s test.Abbreviation: SE, standard error.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494617&req=5

f3-ott-8-1611: Publication bias assessment of CYP1A1 MspI polymorphism and lung cancer risk under the allele genetic model.Notes: (A) Begg’s funnel plot. (B) Egger’s test.Abbreviation: SE, standard error.
Mentions: In order to compare the difference and evaluate the sensitivity of the meta-analysis, we used both models (fixed-effects and random-effects) to evaluate the stability of the meta-analysis. None of the results were materially altered (Table 2). Hence, the results of the sensitivity analysis suggest that the data in this meta-analysis are relatively stable and credible. Begg’s funnel plot and Egger’s test were performed to assess publication bias. The shape of the funnel plots did not reveal obvious asymmetry (Figure 3A). Subsequently, the Egger’s test was used to provide statistical evidence of funnel plot symmetry. The Egger’s test indicated that there was no obvious publication bias under the allele model in overall analysis (Figure 3B) (t=2.09, P=0.058).

Bottom Line: To clarify the effects of CYP1A1 exon 7 polymorphism on the risk of LC, an updated meta-analysis was performed in the Chinese population.Overall, significant association was found between CYP1A1 exon 7 polymorphism and LC risk when all studies in the Chinese population were pooled into this meta-analysis (GG versus AA: OR = 1.71, 95% CI: 1.46-2.01; GG versus AG: OR = 1.41, 95% CI: 1.21-1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16-1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32-1.76).In subgroup analyses stratified by ethnicity, source of controls, and geographical locations, significantly increased risk was found in Chinese Han people, in population-based studies, in hospital-based studies, in South China, and in North China.

View Article: PubMed Central - PubMed

Affiliation: Respiratory Department, Beijing Tiantan Hospital affiliated to Capital Medical University, Beijing, People's Republic of China.

ABSTRACT

Background: Although many epidemiologic studies have investigated the cytochrome P450 1A1 (CYP1A1) exon 7 gene polymorphism and its association with lung cancer (LC), definitive conclusions cannot be drawn.

Objective: To clarify the effects of CYP1A1 exon 7 polymorphism on the risk of LC, an updated meta-analysis was performed in the Chinese population.

Methods: Related studies were identified from PubMed, Springer Link, Ovid, the Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biology Medicine (CBM) databases until October 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations.

Results: A total of 25 articles including 3,540 LC cases and 5,284 controls were included in this meta-analysis. Overall, significant association was found between CYP1A1 exon 7 polymorphism and LC risk when all studies in the Chinese population were pooled into this meta-analysis (GG versus AA: OR = 1.71, 95% CI: 1.46-2.01; GG versus AG: OR = 1.41, 95% CI: 1.21-1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16-1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32-1.76). In subgroup analyses stratified by ethnicity, source of controls, and geographical locations, significantly increased risk was found in Chinese Han people, in population-based studies, in hospital-based studies, in South China, and in North China.

Conclusion: This meta-analysis provides the evidence that CYP1A1 exon 7 polymorphism may contribute to LC development in the Chinese population, and studies with a larger sample size and wider population spectrum are warranted to verify this finding.

No MeSH data available.


Related in: MedlinePlus