Limits...
Cytochrome P450 1A1 exon 7 polymorphism and susceptibility to lung cancer in the Chinese population: an updated meta-analysis and review.

Wei XP, Hu J - Onco Targets Ther (2015)

Bottom Line: To clarify the effects of CYP1A1 exon 7 polymorphism on the risk of LC, an updated meta-analysis was performed in the Chinese population.Overall, significant association was found between CYP1A1 exon 7 polymorphism and LC risk when all studies in the Chinese population were pooled into this meta-analysis (GG versus AA: OR = 1.71, 95% CI: 1.46-2.01; GG versus AG: OR = 1.41, 95% CI: 1.21-1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16-1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32-1.76).In subgroup analyses stratified by ethnicity, source of controls, and geographical locations, significantly increased risk was found in Chinese Han people, in population-based studies, in hospital-based studies, in South China, and in North China.

View Article: PubMed Central - PubMed

Affiliation: Respiratory Department, Beijing Tiantan Hospital affiliated to Capital Medical University, Beijing, People's Republic of China.

ABSTRACT

Background: Although many epidemiologic studies have investigated the cytochrome P450 1A1 (CYP1A1) exon 7 gene polymorphism and its association with lung cancer (LC), definitive conclusions cannot be drawn.

Objective: To clarify the effects of CYP1A1 exon 7 polymorphism on the risk of LC, an updated meta-analysis was performed in the Chinese population.

Methods: Related studies were identified from PubMed, Springer Link, Ovid, the Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biology Medicine (CBM) databases until October 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations.

Results: A total of 25 articles including 3,540 LC cases and 5,284 controls were included in this meta-analysis. Overall, significant association was found between CYP1A1 exon 7 polymorphism and LC risk when all studies in the Chinese population were pooled into this meta-analysis (GG versus AA: OR = 1.71, 95% CI: 1.46-2.01; GG versus AG: OR = 1.41, 95% CI: 1.21-1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16-1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32-1.76). In subgroup analyses stratified by ethnicity, source of controls, and geographical locations, significantly increased risk was found in Chinese Han people, in population-based studies, in hospital-based studies, in South China, and in North China.

Conclusion: This meta-analysis provides the evidence that CYP1A1 exon 7 polymorphism may contribute to LC development in the Chinese population, and studies with a larger sample size and wider population spectrum are warranted to verify this finding.

No MeSH data available.


Related in: MedlinePlus

Forest plot (random-effects model) of lung cancer risk associated with CYP1A1 MspI polymorphism using the allele genetic model.Note: Weights are from random-effects analysis.Abbreviations: CI, confidence interval; OR, odds ratio.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4494617&req=5

f2-ott-8-1611: Forest plot (random-effects model) of lung cancer risk associated with CYP1A1 MspI polymorphism using the allele genetic model.Note: Weights are from random-effects analysis.Abbreviations: CI, confidence interval; OR, odds ratio.

Mentions: Table 2 lists the primary results. Overall, a significantly elevated risk of lung cancer was associated with all variants of CYP1A1 exon 7 (G versus A: OR = 1.30, 95% CI: 1.17–1.45; GG versus AA: OR = 1.71, 95% CI: 1.46–2.01; GG versus AG: OR = 1.41, 95% CI: 1.21–1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16–1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32–1.76) (Figure 2). However, there was significant heterogeneity between some models. Hence, we then performed subgroup analysis by geographical locations, ethnicity, and source of controls. In the stratified analysis by geographical locations, significantly increased risk was found both in North China (G versus A: OR = 1.28, 95% CI: 1.13–1.46; GG versus AA: OR = 1.60, 95% CI: 1.33–1.91; GG versus AG: OR = 1.31, 95% CI: 1.10–1.55; GG + AG versus AA: OR = 1.41, 95% CI: 1.15–1.73; GG versus AA + AG: OR = 1.41, 95% CI: 1.20–1.65) and South China (G versus A: OR = 1.39, 95% CI: 1.10–1.76; GG versus AA: OR = 2.13, 95% CI: 1.51–3.01; GG versus AG: OR = 1.80, 95% CI: 1.26–2.58; GG versus AA + AG: OR = 2.01, 95% CI: 1.44–2.81). In the stratified analysis by source of controls, significantly increased risk was found both in the population-based studies (G versus A: OR = 1.32, 95% CI: 1.15–1.50; GG versus AA: OR = 1.77, 95% CI: 1.36–2.31; GG versus AG: OR = 1.38, 95% CI: 1.15–1.66; GG + AG versus AA: OR = 1.40, 95% CI: 1.15–1.71; GG versus 1G: OR = 1.49, 95% CI: 1.25–1.77) and hospital-based studies (G versus A: OR = 1.29, 95% CI: 1.13–1.47; GG versus AA: OR = 2.05, 95% CI: 1.50–2.79; GG versus AG: OR = 1.44, 95% CI: 1.10–1.88; GG + AG versus AA: OR = 1.39, 95% CI: 1.13–1.72; GG versus AA + AG: OR = 1.59, 95% CI: 1.23–2.06). In the subgroup analysis by ethnicity, significantly increased association was found in Chinese Han people (GG versus AA: OR =1.59, 95% CI: 1.11–2.30; GG versus AG: OR = 1.38, 95% CI: 1.12–1.68; GG versus AA + AG: OR = 1.40, 95% CI: 1.16–1.70).


Cytochrome P450 1A1 exon 7 polymorphism and susceptibility to lung cancer in the Chinese population: an updated meta-analysis and review.

Wei XP, Hu J - Onco Targets Ther (2015)

Forest plot (random-effects model) of lung cancer risk associated with CYP1A1 MspI polymorphism using the allele genetic model.Note: Weights are from random-effects analysis.Abbreviations: CI, confidence interval; OR, odds ratio.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494617&req=5

f2-ott-8-1611: Forest plot (random-effects model) of lung cancer risk associated with CYP1A1 MspI polymorphism using the allele genetic model.Note: Weights are from random-effects analysis.Abbreviations: CI, confidence interval; OR, odds ratio.
Mentions: Table 2 lists the primary results. Overall, a significantly elevated risk of lung cancer was associated with all variants of CYP1A1 exon 7 (G versus A: OR = 1.30, 95% CI: 1.17–1.45; GG versus AA: OR = 1.71, 95% CI: 1.46–2.01; GG versus AG: OR = 1.41, 95% CI: 1.21–1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16–1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32–1.76) (Figure 2). However, there was significant heterogeneity between some models. Hence, we then performed subgroup analysis by geographical locations, ethnicity, and source of controls. In the stratified analysis by geographical locations, significantly increased risk was found both in North China (G versus A: OR = 1.28, 95% CI: 1.13–1.46; GG versus AA: OR = 1.60, 95% CI: 1.33–1.91; GG versus AG: OR = 1.31, 95% CI: 1.10–1.55; GG + AG versus AA: OR = 1.41, 95% CI: 1.15–1.73; GG versus AA + AG: OR = 1.41, 95% CI: 1.20–1.65) and South China (G versus A: OR = 1.39, 95% CI: 1.10–1.76; GG versus AA: OR = 2.13, 95% CI: 1.51–3.01; GG versus AG: OR = 1.80, 95% CI: 1.26–2.58; GG versus AA + AG: OR = 2.01, 95% CI: 1.44–2.81). In the stratified analysis by source of controls, significantly increased risk was found both in the population-based studies (G versus A: OR = 1.32, 95% CI: 1.15–1.50; GG versus AA: OR = 1.77, 95% CI: 1.36–2.31; GG versus AG: OR = 1.38, 95% CI: 1.15–1.66; GG + AG versus AA: OR = 1.40, 95% CI: 1.15–1.71; GG versus 1G: OR = 1.49, 95% CI: 1.25–1.77) and hospital-based studies (G versus A: OR = 1.29, 95% CI: 1.13–1.47; GG versus AA: OR = 2.05, 95% CI: 1.50–2.79; GG versus AG: OR = 1.44, 95% CI: 1.10–1.88; GG + AG versus AA: OR = 1.39, 95% CI: 1.13–1.72; GG versus AA + AG: OR = 1.59, 95% CI: 1.23–2.06). In the subgroup analysis by ethnicity, significantly increased association was found in Chinese Han people (GG versus AA: OR =1.59, 95% CI: 1.11–2.30; GG versus AG: OR = 1.38, 95% CI: 1.12–1.68; GG versus AA + AG: OR = 1.40, 95% CI: 1.16–1.70).

Bottom Line: To clarify the effects of CYP1A1 exon 7 polymorphism on the risk of LC, an updated meta-analysis was performed in the Chinese population.Overall, significant association was found between CYP1A1 exon 7 polymorphism and LC risk when all studies in the Chinese population were pooled into this meta-analysis (GG versus AA: OR = 1.71, 95% CI: 1.46-2.01; GG versus AG: OR = 1.41, 95% CI: 1.21-1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16-1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32-1.76).In subgroup analyses stratified by ethnicity, source of controls, and geographical locations, significantly increased risk was found in Chinese Han people, in population-based studies, in hospital-based studies, in South China, and in North China.

View Article: PubMed Central - PubMed

Affiliation: Respiratory Department, Beijing Tiantan Hospital affiliated to Capital Medical University, Beijing, People's Republic of China.

ABSTRACT

Background: Although many epidemiologic studies have investigated the cytochrome P450 1A1 (CYP1A1) exon 7 gene polymorphism and its association with lung cancer (LC), definitive conclusions cannot be drawn.

Objective: To clarify the effects of CYP1A1 exon 7 polymorphism on the risk of LC, an updated meta-analysis was performed in the Chinese population.

Methods: Related studies were identified from PubMed, Springer Link, Ovid, the Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biology Medicine (CBM) databases until October 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations.

Results: A total of 25 articles including 3,540 LC cases and 5,284 controls were included in this meta-analysis. Overall, significant association was found between CYP1A1 exon 7 polymorphism and LC risk when all studies in the Chinese population were pooled into this meta-analysis (GG versus AA: OR = 1.71, 95% CI: 1.46-2.01; GG versus AG: OR = 1.41, 95% CI: 1.21-1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16-1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32-1.76). In subgroup analyses stratified by ethnicity, source of controls, and geographical locations, significantly increased risk was found in Chinese Han people, in population-based studies, in hospital-based studies, in South China, and in North China.

Conclusion: This meta-analysis provides the evidence that CYP1A1 exon 7 polymorphism may contribute to LC development in the Chinese population, and studies with a larger sample size and wider population spectrum are warranted to verify this finding.

No MeSH data available.


Related in: MedlinePlus