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Cytochrome P450 1A1 exon 7 polymorphism and susceptibility to lung cancer in the Chinese population: an updated meta-analysis and review.

Wei XP, Hu J - Onco Targets Ther (2015)

Bottom Line: To clarify the effects of CYP1A1 exon 7 polymorphism on the risk of LC, an updated meta-analysis was performed in the Chinese population.Overall, significant association was found between CYP1A1 exon 7 polymorphism and LC risk when all studies in the Chinese population were pooled into this meta-analysis (GG versus AA: OR = 1.71, 95% CI: 1.46-2.01; GG versus AG: OR = 1.41, 95% CI: 1.21-1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16-1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32-1.76).In subgroup analyses stratified by ethnicity, source of controls, and geographical locations, significantly increased risk was found in Chinese Han people, in population-based studies, in hospital-based studies, in South China, and in North China.

View Article: PubMed Central - PubMed

Affiliation: Respiratory Department, Beijing Tiantan Hospital affiliated to Capital Medical University, Beijing, People's Republic of China.

ABSTRACT

Background: Although many epidemiologic studies have investigated the cytochrome P450 1A1 (CYP1A1) exon 7 gene polymorphism and its association with lung cancer (LC), definitive conclusions cannot be drawn.

Objective: To clarify the effects of CYP1A1 exon 7 polymorphism on the risk of LC, an updated meta-analysis was performed in the Chinese population.

Methods: Related studies were identified from PubMed, Springer Link, Ovid, the Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biology Medicine (CBM) databases until October 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations.

Results: A total of 25 articles including 3,540 LC cases and 5,284 controls were included in this meta-analysis. Overall, significant association was found between CYP1A1 exon 7 polymorphism and LC risk when all studies in the Chinese population were pooled into this meta-analysis (GG versus AA: OR = 1.71, 95% CI: 1.46-2.01; GG versus AG: OR = 1.41, 95% CI: 1.21-1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16-1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32-1.76). In subgroup analyses stratified by ethnicity, source of controls, and geographical locations, significantly increased risk was found in Chinese Han people, in population-based studies, in hospital-based studies, in South China, and in North China.

Conclusion: This meta-analysis provides the evidence that CYP1A1 exon 7 polymorphism may contribute to LC development in the Chinese population, and studies with a larger sample size and wider population spectrum are warranted to verify this finding.

No MeSH data available.


Related in: MedlinePlus

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f1-ott-8-1611: Flow diagram of the literature search.

Mentions: According to the inclusion criteria, 25 case–control studies14–38 were included and 163 articles were excluded. The publication year of included studies ranged from 1998 to 2014. A flowchart of the study selection process is shown in Figure 1. In total, 3,540 lung cancer cases and 5,284 controls were involved in this meta-analysis, which evaluated the relationship between CYP1A1 exon 7 polymorphism and lung cancer risk. The source of controls was mainly based on a healthy population. Fifteen of these studies were written in Chinese, and ten studies were in English. The characteristics of the included studies are summarized in Table 1.


Cytochrome P450 1A1 exon 7 polymorphism and susceptibility to lung cancer in the Chinese population: an updated meta-analysis and review.

Wei XP, Hu J - Onco Targets Ther (2015)

Flow diagram of the literature search.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494617&req=5

f1-ott-8-1611: Flow diagram of the literature search.
Mentions: According to the inclusion criteria, 25 case–control studies14–38 were included and 163 articles were excluded. The publication year of included studies ranged from 1998 to 2014. A flowchart of the study selection process is shown in Figure 1. In total, 3,540 lung cancer cases and 5,284 controls were involved in this meta-analysis, which evaluated the relationship between CYP1A1 exon 7 polymorphism and lung cancer risk. The source of controls was mainly based on a healthy population. Fifteen of these studies were written in Chinese, and ten studies were in English. The characteristics of the included studies are summarized in Table 1.

Bottom Line: To clarify the effects of CYP1A1 exon 7 polymorphism on the risk of LC, an updated meta-analysis was performed in the Chinese population.Overall, significant association was found between CYP1A1 exon 7 polymorphism and LC risk when all studies in the Chinese population were pooled into this meta-analysis (GG versus AA: OR = 1.71, 95% CI: 1.46-2.01; GG versus AG: OR = 1.41, 95% CI: 1.21-1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16-1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32-1.76).In subgroup analyses stratified by ethnicity, source of controls, and geographical locations, significantly increased risk was found in Chinese Han people, in population-based studies, in hospital-based studies, in South China, and in North China.

View Article: PubMed Central - PubMed

Affiliation: Respiratory Department, Beijing Tiantan Hospital affiliated to Capital Medical University, Beijing, People's Republic of China.

ABSTRACT

Background: Although many epidemiologic studies have investigated the cytochrome P450 1A1 (CYP1A1) exon 7 gene polymorphism and its association with lung cancer (LC), definitive conclusions cannot be drawn.

Objective: To clarify the effects of CYP1A1 exon 7 polymorphism on the risk of LC, an updated meta-analysis was performed in the Chinese population.

Methods: Related studies were identified from PubMed, Springer Link, Ovid, the Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biology Medicine (CBM) databases until October 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations.

Results: A total of 25 articles including 3,540 LC cases and 5,284 controls were included in this meta-analysis. Overall, significant association was found between CYP1A1 exon 7 polymorphism and LC risk when all studies in the Chinese population were pooled into this meta-analysis (GG versus AA: OR = 1.71, 95% CI: 1.46-2.01; GG versus AG: OR = 1.41, 95% CI: 1.21-1.64; GG + AG versus AA: OR = 1.37, 95% CI: 1.16-1.62; GG versus AA + AG: OR = 1.52, 95% CI: 1.32-1.76). In subgroup analyses stratified by ethnicity, source of controls, and geographical locations, significantly increased risk was found in Chinese Han people, in population-based studies, in hospital-based studies, in South China, and in North China.

Conclusion: This meta-analysis provides the evidence that CYP1A1 exon 7 polymorphism may contribute to LC development in the Chinese population, and studies with a larger sample size and wider population spectrum are warranted to verify this finding.

No MeSH data available.


Related in: MedlinePlus