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A Novel Rat Model of Intramedullary Tibia Fracture Fixation Using Polyetheretherketone Threaded Rod.

Jin Z, Sun Y, Guan Y, Yu G - Plast Reconstr Surg Glob Open (2015)

Bottom Line: X-ray examination was performed at 0, 4, and 8 weeks postoperatively.Histological analysis was conducted via hematoxylin-eosin staining of nondecalcified tissue sections.This innovative model is simple and effective, providing a new selection in future biomedical research.

View Article: PubMed Central - PubMed

Affiliation: Department of Joint Surgery and Sports Medicine, First Hospital of China Medical University, Shenyang, China; and Department of Radiological Diagnosis and Interventional Treatment, First Hospital of China Medical University, Shenyang, China.

ABSTRACT

Background: The rat fracture fixation models have been widely adopted, but current implant designs suffer from operational difficulty, massive soft-tissue dissection, and radiological intervention. The authors developed a new tibia fracture-healing model using minor invasive intramedullary fixations with polyetheretherketone (PEEK) threaded rods, which have excellent x-ray translucency and no magnetic resonance artifact.

Methods: Tibia fractures of 6 adult male Sprague-Dawley rats were fixed with intramedullary PEEK threaded rods. X-ray examination was performed at 0, 4, and 8 weeks postoperatively. Histological analysis was conducted via hematoxylin-eosin staining of nondecalcified tissue sections.

Results: Radiological fracture healing was observed at 8 weeks postoperatively. Histology demonstrated fracture gap bridging and bone ingrowth adjacent to PEEK.

Conclusion: This innovative model is simple and effective, providing a new selection in future biomedical research.

No MeSH data available.


Related in: MedlinePlus

Postoperative plain film at 8 weeks showing fracture healing.
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Figure 2: Postoperative plain film at 8 weeks showing fracture healing.

Mentions: All animals returned to full weight bearing after 48 hours. There were no postoperative wound complications. Radiological fracture healing was achieved at 8 weeks (Fig. 2), with no visible continu ous osteotomy line. Macroscopic examination of the specimen showed that the fracture ends were united by newly formed bone tissue, and qualitative morphological examination of hard-tissue sections revealed new bone ingrowth surrounding PEEK rods (Fig. 3) (see Fig. 2, Supplemental Digital Content 2, which displays a macroscopic examination, http://links.lww.com/PRSGO/A102).


A Novel Rat Model of Intramedullary Tibia Fracture Fixation Using Polyetheretherketone Threaded Rod.

Jin Z, Sun Y, Guan Y, Yu G - Plast Reconstr Surg Glob Open (2015)

Postoperative plain film at 8 weeks showing fracture healing.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4494487&req=5

Figure 2: Postoperative plain film at 8 weeks showing fracture healing.
Mentions: All animals returned to full weight bearing after 48 hours. There were no postoperative wound complications. Radiological fracture healing was achieved at 8 weeks (Fig. 2), with no visible continu ous osteotomy line. Macroscopic examination of the specimen showed that the fracture ends were united by newly formed bone tissue, and qualitative morphological examination of hard-tissue sections revealed new bone ingrowth surrounding PEEK rods (Fig. 3) (see Fig. 2, Supplemental Digital Content 2, which displays a macroscopic examination, http://links.lww.com/PRSGO/A102).

Bottom Line: X-ray examination was performed at 0, 4, and 8 weeks postoperatively.Histological analysis was conducted via hematoxylin-eosin staining of nondecalcified tissue sections.This innovative model is simple and effective, providing a new selection in future biomedical research.

View Article: PubMed Central - PubMed

Affiliation: Department of Joint Surgery and Sports Medicine, First Hospital of China Medical University, Shenyang, China; and Department of Radiological Diagnosis and Interventional Treatment, First Hospital of China Medical University, Shenyang, China.

ABSTRACT

Background: The rat fracture fixation models have been widely adopted, but current implant designs suffer from operational difficulty, massive soft-tissue dissection, and radiological intervention. The authors developed a new tibia fracture-healing model using minor invasive intramedullary fixations with polyetheretherketone (PEEK) threaded rods, which have excellent x-ray translucency and no magnetic resonance artifact.

Methods: Tibia fractures of 6 adult male Sprague-Dawley rats were fixed with intramedullary PEEK threaded rods. X-ray examination was performed at 0, 4, and 8 weeks postoperatively. Histological analysis was conducted via hematoxylin-eosin staining of nondecalcified tissue sections.

Results: Radiological fracture healing was observed at 8 weeks postoperatively. Histology demonstrated fracture gap bridging and bone ingrowth adjacent to PEEK.

Conclusion: This innovative model is simple and effective, providing a new selection in future biomedical research.

No MeSH data available.


Related in: MedlinePlus