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Effects of Transfer from Breeding to Research Facility on the Welfare of Rats.

Arts JW, Oosterhuis NR, Kramer K, Ohl F - Animals (Basel) (2014)

Bottom Line: Transfer from the breeding facility to a research facility is a stressful event for laboratory animals.This study measured ambient and body temperature, corticosterone and glucose levels, body weight, behavior and water and food intake before, during and after transfer in Wistar rats.Male rats need to habituate for at least one week, females for two weeks after transfer.

View Article: PubMed Central - PubMed

Affiliation: Department of Animals in Science & Society, Division of Animal Welfare & Laboratory Animal Science, Veterinary Faculty, Utrecht University, Utrecht, 3584 CM, The Netherlands. jarts@harlan.com.

ABSTRACT
Transfer from the breeding facility to a research facility is a stressful event for laboratory animals. Heat stress has been reported to constitute one of the major concerns during transport of animals. This study measured ambient and body temperature, corticosterone and glucose levels, body weight, behavior and water and food intake before, during and after transfer in Wistar rats. Decreased body weight, water and food intake were observed on the day of transfer in rats. Environmental temperature strongly affected body temperature of rats and needs to be controlled. Male rats need to habituate for at least one week, females for two weeks after transfer.

No MeSH data available.


Related in: MedlinePlus

Plasma corticosterone levels (nmol/L) in male (squares) and female (circles), transferred (black symbols-solid line) and control (white symbols-dotted line) rats, one week before, on day of transfer and one, two and three weeks after transfer (n = 8). * indicates significant difference between TF and CO.
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animals-04-00712-f004: Plasma corticosterone levels (nmol/L) in male (squares) and female (circles), transferred (black symbols-solid line) and control (white symbols-dotted line) rats, one week before, on day of transfer and one, two and three weeks after transfer (n = 8). * indicates significant difference between TF and CO.

Mentions: In CORT levels a time × sex interaction (F(4,112) = 21.14, p < 0.001) and a time × treatment interaction (F(4,112) = 3.93, p = 0.005) were found (Figure 4). Female rats had higher CORT levels that also increased more over time than male rats (F(1,28) = 80.96, p < 0.001).


Effects of Transfer from Breeding to Research Facility on the Welfare of Rats.

Arts JW, Oosterhuis NR, Kramer K, Ohl F - Animals (Basel) (2014)

Plasma corticosterone levels (nmol/L) in male (squares) and female (circles), transferred (black symbols-solid line) and control (white symbols-dotted line) rats, one week before, on day of transfer and one, two and three weeks after transfer (n = 8). * indicates significant difference between TF and CO.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494421&req=5

animals-04-00712-f004: Plasma corticosterone levels (nmol/L) in male (squares) and female (circles), transferred (black symbols-solid line) and control (white symbols-dotted line) rats, one week before, on day of transfer and one, two and three weeks after transfer (n = 8). * indicates significant difference between TF and CO.
Mentions: In CORT levels a time × sex interaction (F(4,112) = 21.14, p < 0.001) and a time × treatment interaction (F(4,112) = 3.93, p = 0.005) were found (Figure 4). Female rats had higher CORT levels that also increased more over time than male rats (F(1,28) = 80.96, p < 0.001).

Bottom Line: Transfer from the breeding facility to a research facility is a stressful event for laboratory animals.This study measured ambient and body temperature, corticosterone and glucose levels, body weight, behavior and water and food intake before, during and after transfer in Wistar rats.Male rats need to habituate for at least one week, females for two weeks after transfer.

View Article: PubMed Central - PubMed

Affiliation: Department of Animals in Science & Society, Division of Animal Welfare & Laboratory Animal Science, Veterinary Faculty, Utrecht University, Utrecht, 3584 CM, The Netherlands. jarts@harlan.com.

ABSTRACT
Transfer from the breeding facility to a research facility is a stressful event for laboratory animals. Heat stress has been reported to constitute one of the major concerns during transport of animals. This study measured ambient and body temperature, corticosterone and glucose levels, body weight, behavior and water and food intake before, during and after transfer in Wistar rats. Decreased body weight, water and food intake were observed on the day of transfer in rats. Environmental temperature strongly affected body temperature of rats and needs to be controlled. Male rats need to habituate for at least one week, females for two weeks after transfer.

No MeSH data available.


Related in: MedlinePlus