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Vaccine Adjuvants: from 1920 to 2015 and Beyond.

Pasquale AD, Preiss S, Silva FT, Garçon N - Vaccines (Basel) (2015)

Bottom Line: While early adjuvants (aluminum, oil-in-water emulsions) were used empirically, rapidly increasing knowledge on how the immune system interacts with pathogens means that there is increased understanding of the role of adjuvants and how the formulation of modern vaccines can be better tailored towards the desired clinical benefit.Continuing safety evaluation of licensed vaccines containing adjuvants/adjuvant systems suggests that their individual benefit-risk profile remains favorable.Adjuvants contribute to the initiation of the innate immune response induced by antigens; exemplified by inflammatory responses at the injection site, with mostly localized and short-lived effects.

View Article: PubMed Central - PubMed

Affiliation: GSK Vaccines, Avenue Fleming, 1300 Wavre, Belgium. alberta.di-pasquale@gsk.com.

ABSTRACT
The concept of stimulating the body's immune response is the basis underlying vaccination. Vaccines act by initiating the innate immune response and activating antigen presenting cells (APCs), thereby inducing a protective adaptive immune response to a pathogen antigen. Adjuvants are substances added to vaccines to enhance the immunogenicity of highly purified antigens that have insufficient immunostimulatory capabilities, and have been used in human vaccines for more than 90 years. While early adjuvants (aluminum, oil-in-water emulsions) were used empirically, rapidly increasing knowledge on how the immune system interacts with pathogens means that there is increased understanding of the role of adjuvants and how the formulation of modern vaccines can be better tailored towards the desired clinical benefit. Continuing safety evaluation of licensed vaccines containing adjuvants/adjuvant systems suggests that their individual benefit-risk profile remains favorable. Adjuvants contribute to the initiation of the innate immune response induced by antigens; exemplified by inflammatory responses at the injection site, with mostly localized and short-lived effects. Activated effectors (such as APCs) then move to draining lymph nodes where they direct the type, magnitude and quality of the adaptive immune response. Thus, the right match of antigens and adjuvants can potentiate downstream adaptive immune responses, enabling the development of new efficacious vaccines. Many infectious diseases of worldwide significance are not currently preventable by vaccination. Adjuvants are the most advanced new technology in the search for new vaccines against challenging pathogens and for vulnerable populations that respond poorly to traditional vaccines.

No MeSH data available.


Related in: MedlinePlus

The immune response to vaccination with and without adjuvant.
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vaccines-03-00320-f004: The immune response to vaccination with and without adjuvant.

Mentions: Highly purified vaccine components frequently lack PAMPs, which means that the initial innate immune response is not activated such that an effective downstream adaptive response occurs. It is thought that the primary mechanism of action of adjuvants is on the innate immune response (Figure 4). Adjuvants can act like PAMPs, triggering the innate immune response through a variety of mechanisms, to identify the vaccine components as a “threat”, with activation and maturation of APCs and initiation of downstream adaptive immune activities [26].


Vaccine Adjuvants: from 1920 to 2015 and Beyond.

Pasquale AD, Preiss S, Silva FT, Garçon N - Vaccines (Basel) (2015)

The immune response to vaccination with and without adjuvant.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494348&req=5

vaccines-03-00320-f004: The immune response to vaccination with and without adjuvant.
Mentions: Highly purified vaccine components frequently lack PAMPs, which means that the initial innate immune response is not activated such that an effective downstream adaptive response occurs. It is thought that the primary mechanism of action of adjuvants is on the innate immune response (Figure 4). Adjuvants can act like PAMPs, triggering the innate immune response through a variety of mechanisms, to identify the vaccine components as a “threat”, with activation and maturation of APCs and initiation of downstream adaptive immune activities [26].

Bottom Line: While early adjuvants (aluminum, oil-in-water emulsions) were used empirically, rapidly increasing knowledge on how the immune system interacts with pathogens means that there is increased understanding of the role of adjuvants and how the formulation of modern vaccines can be better tailored towards the desired clinical benefit.Continuing safety evaluation of licensed vaccines containing adjuvants/adjuvant systems suggests that their individual benefit-risk profile remains favorable.Adjuvants contribute to the initiation of the innate immune response induced by antigens; exemplified by inflammatory responses at the injection site, with mostly localized and short-lived effects.

View Article: PubMed Central - PubMed

Affiliation: GSK Vaccines, Avenue Fleming, 1300 Wavre, Belgium. alberta.di-pasquale@gsk.com.

ABSTRACT
The concept of stimulating the body's immune response is the basis underlying vaccination. Vaccines act by initiating the innate immune response and activating antigen presenting cells (APCs), thereby inducing a protective adaptive immune response to a pathogen antigen. Adjuvants are substances added to vaccines to enhance the immunogenicity of highly purified antigens that have insufficient immunostimulatory capabilities, and have been used in human vaccines for more than 90 years. While early adjuvants (aluminum, oil-in-water emulsions) were used empirically, rapidly increasing knowledge on how the immune system interacts with pathogens means that there is increased understanding of the role of adjuvants and how the formulation of modern vaccines can be better tailored towards the desired clinical benefit. Continuing safety evaluation of licensed vaccines containing adjuvants/adjuvant systems suggests that their individual benefit-risk profile remains favorable. Adjuvants contribute to the initiation of the innate immune response induced by antigens; exemplified by inflammatory responses at the injection site, with mostly localized and short-lived effects. Activated effectors (such as APCs) then move to draining lymph nodes where they direct the type, magnitude and quality of the adaptive immune response. Thus, the right match of antigens and adjuvants can potentiate downstream adaptive immune responses, enabling the development of new efficacious vaccines. Many infectious diseases of worldwide significance are not currently preventable by vaccination. Adjuvants are the most advanced new technology in the search for new vaccines against challenging pathogens and for vulnerable populations that respond poorly to traditional vaccines.

No MeSH data available.


Related in: MedlinePlus