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Identifying the Conditions Under Which Antibodies Protect Against Infection by Equine Infectious Anemia Virus.

Schwartz EJ, Smith RJ - Vaccines (Basel) (2014)

Bottom Line: A more complete understanding is needed of antibody protection against lentivirus infection, as well as the role of mutation in resistance to an antibody vaccine.In addition, a three-strain competition model is considered in which a second mutant strain may coexist with the first mutant strain.The conditions that permit viral escape by the mutant strains are determined, as are the effects of variation in the model parameters.

View Article: PubMed Central - PubMed

Affiliation: School of Biological Sciences and Department of Mathematics, Washington State University, Pullman, WA 99164, USA. ejs@wsu.edu.

ABSTRACT
The ability to predict the conditions under which antibodies protect against viral infection would transform our approach to vaccine development. A more complete understanding is needed of antibody protection against lentivirus infection, as well as the role of mutation in resistance to an antibody vaccine. Recently, an example of antibody-mediated vaccine protection has been shown via passive transfer of neutralizing antibodies before equine infectious anemia virus (EIAV) infection of horses with severe combined immunodeficiency (SCID). Viral dynamic modeling of antibody protection from EIAV infection in SCID horses may lead to insights into the mechanisms of control of infection by antibody vaccination. In this work, such a model is constructed in conjunction with data from EIAV infection of SCID horses to gain insights into multiple strain competition in the presence of antibody control. Conditions are determined under which wild-type infection is eradicated with the antibody vaccine. In addition, a three-strain competition model is considered in which a second mutant strain may coexist with the first mutant strain. The conditions that permit viral escape by the mutant strains are determined, as are the effects of variation in the model parameters. This work extends the current understanding of competition and antibody control in lentiviral infection, which may provide insights into the development of vaccines that stimulate the immune system to control infection effectively.

No MeSH data available.


Related in: MedlinePlus

Tornado plot showing partial rank correlation coefficients (PRCCs) of R0 to its dependent parameters. The parameter with the largest impact on R0 is the viral growth rate, rW.
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vaccines-02-00397-f007: Tornado plot showing partial rank correlation coefficients (PRCCs) of R0 to its dependent parameters. The parameter with the largest impact on R0 is the viral growth rate, rW.

Mentions: As can be seen in Figure 7, the virus growth rate has the greatest impact on the outcome. The outcome here is the value of R0, which is the difference between eradication and persistence. The Monte Carlo simulations are illustrated in Figure 8. Each dot is one of 1000 simulations. The mutation rates have very little effect on R0 when they are varied, but the virus growth and clearance rates have a noticeable trend.


Identifying the Conditions Under Which Antibodies Protect Against Infection by Equine Infectious Anemia Virus.

Schwartz EJ, Smith RJ - Vaccines (Basel) (2014)

Tornado plot showing partial rank correlation coefficients (PRCCs) of R0 to its dependent parameters. The parameter with the largest impact on R0 is the viral growth rate, rW.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494265&req=5

vaccines-02-00397-f007: Tornado plot showing partial rank correlation coefficients (PRCCs) of R0 to its dependent parameters. The parameter with the largest impact on R0 is the viral growth rate, rW.
Mentions: As can be seen in Figure 7, the virus growth rate has the greatest impact on the outcome. The outcome here is the value of R0, which is the difference between eradication and persistence. The Monte Carlo simulations are illustrated in Figure 8. Each dot is one of 1000 simulations. The mutation rates have very little effect on R0 when they are varied, but the virus growth and clearance rates have a noticeable trend.

Bottom Line: A more complete understanding is needed of antibody protection against lentivirus infection, as well as the role of mutation in resistance to an antibody vaccine.In addition, a three-strain competition model is considered in which a second mutant strain may coexist with the first mutant strain.The conditions that permit viral escape by the mutant strains are determined, as are the effects of variation in the model parameters.

View Article: PubMed Central - PubMed

Affiliation: School of Biological Sciences and Department of Mathematics, Washington State University, Pullman, WA 99164, USA. ejs@wsu.edu.

ABSTRACT
The ability to predict the conditions under which antibodies protect against viral infection would transform our approach to vaccine development. A more complete understanding is needed of antibody protection against lentivirus infection, as well as the role of mutation in resistance to an antibody vaccine. Recently, an example of antibody-mediated vaccine protection has been shown via passive transfer of neutralizing antibodies before equine infectious anemia virus (EIAV) infection of horses with severe combined immunodeficiency (SCID). Viral dynamic modeling of antibody protection from EIAV infection in SCID horses may lead to insights into the mechanisms of control of infection by antibody vaccination. In this work, such a model is constructed in conjunction with data from EIAV infection of SCID horses to gain insights into multiple strain competition in the presence of antibody control. Conditions are determined under which wild-type infection is eradicated with the antibody vaccine. In addition, a three-strain competition model is considered in which a second mutant strain may coexist with the first mutant strain. The conditions that permit viral escape by the mutant strains are determined, as are the effects of variation in the model parameters. This work extends the current understanding of competition and antibody control in lentiviral infection, which may provide insights into the development of vaccines that stimulate the immune system to control infection effectively.

No MeSH data available.


Related in: MedlinePlus