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EBV-Associated Cancer and Autoimmunity: Searching for Therapies.

Capone G, Fasano C, Lucchese G, CalabrĂ² M, Kanduc D - Vaccines (Basel) (2015)

Bottom Line: Epstein-Barr virus (EBV) infects B-, T-, and NK cells and has been associated not only with a wide range of lymphoid malignancies but also with autoimmune diseases such as lupus erythematosus, rheumatoid arthritis and, in particular, multiple sclerosis.Hence, effective immunotherapeutic approaches to eradicate EBV infection might overthrow cancer and autoimmunity incidence.Here we use the concept that protein immunogenicity is allocated in rare peptide sequences and search the Epstein-Barr nuclear antigen 1 (EBNA1) sequence for peptides unique to the viral protein and absent in the human host.

View Article: PubMed Central - PubMed

Affiliation: Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari 70126, Italy. g.capone@biologia.uniba.it.

ABSTRACT
Epstein-Barr virus (EBV) infects B-, T-, and NK cells and has been associated not only with a wide range of lymphoid malignancies but also with autoimmune diseases such as lupus erythematosus, rheumatoid arthritis and, in particular, multiple sclerosis. Hence, effective immunotherapeutic approaches to eradicate EBV infection might overthrow cancer and autoimmunity incidence. However, currently no effective anti-EBV immunotherapy is available. Here we use the concept that protein immunogenicity is allocated in rare peptide sequences and search the Epstein-Barr nuclear antigen 1 (EBNA1) sequence for peptides unique to the viral protein and absent in the human host. We report on a set of unique EBV EBNA1 peptides that might be used in designing peptide-based therapies able to specifically hitting the virus or neutralizing pathogenic autoantibodies.

No MeSH data available.


Related in: MedlinePlus

Pentapeptide identity platform shared between Epstein-Barr virus (EBV) Epstein-Barr nuclear antigen 1 (EBNA1) protein and the human proteome. Peptide aa sequences in one letter code.
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vaccines-03-00074-f001: Pentapeptide identity platform shared between Epstein-Barr virus (EBV) Epstein-Barr nuclear antigen 1 (EBNA1) protein and the human proteome. Peptide aa sequences in one letter code.

Mentions: Figure 1 illustrates the similarity profile of EBV EBNA1 protein sequence to the human proteome at the pentapeptide level. It can be seen that the most part of the 637 pentapeptides that sequentially form the viral protein, are repeatedly present in human proteins. Namely, 622 out of 637 viral pentapeptides are present 66,052 times (including multiple occurrences) in 7312 human proteins [56].


EBV-Associated Cancer and Autoimmunity: Searching for Therapies.

Capone G, Fasano C, Lucchese G, CalabrĂ² M, Kanduc D - Vaccines (Basel) (2015)

Pentapeptide identity platform shared between Epstein-Barr virus (EBV) Epstein-Barr nuclear antigen 1 (EBNA1) protein and the human proteome. Peptide aa sequences in one letter code.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494242&req=5

vaccines-03-00074-f001: Pentapeptide identity platform shared between Epstein-Barr virus (EBV) Epstein-Barr nuclear antigen 1 (EBNA1) protein and the human proteome. Peptide aa sequences in one letter code.
Mentions: Figure 1 illustrates the similarity profile of EBV EBNA1 protein sequence to the human proteome at the pentapeptide level. It can be seen that the most part of the 637 pentapeptides that sequentially form the viral protein, are repeatedly present in human proteins. Namely, 622 out of 637 viral pentapeptides are present 66,052 times (including multiple occurrences) in 7312 human proteins [56].

Bottom Line: Epstein-Barr virus (EBV) infects B-, T-, and NK cells and has been associated not only with a wide range of lymphoid malignancies but also with autoimmune diseases such as lupus erythematosus, rheumatoid arthritis and, in particular, multiple sclerosis.Hence, effective immunotherapeutic approaches to eradicate EBV infection might overthrow cancer and autoimmunity incidence.Here we use the concept that protein immunogenicity is allocated in rare peptide sequences and search the Epstein-Barr nuclear antigen 1 (EBNA1) sequence for peptides unique to the viral protein and absent in the human host.

View Article: PubMed Central - PubMed

Affiliation: Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari 70126, Italy. g.capone@biologia.uniba.it.

ABSTRACT
Epstein-Barr virus (EBV) infects B-, T-, and NK cells and has been associated not only with a wide range of lymphoid malignancies but also with autoimmune diseases such as lupus erythematosus, rheumatoid arthritis and, in particular, multiple sclerosis. Hence, effective immunotherapeutic approaches to eradicate EBV infection might overthrow cancer and autoimmunity incidence. However, currently no effective anti-EBV immunotherapy is available. Here we use the concept that protein immunogenicity is allocated in rare peptide sequences and search the Epstein-Barr nuclear antigen 1 (EBNA1) sequence for peptides unique to the viral protein and absent in the human host. We report on a set of unique EBV EBNA1 peptides that might be used in designing peptide-based therapies able to specifically hitting the virus or neutralizing pathogenic autoantibodies.

No MeSH data available.


Related in: MedlinePlus