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The Potential Impact of Preventive HIV Vaccines in China: Results and Benefits of a Multi-Province Modeling Collaboration.

Harmon T, Guo W, Stover J, Wu Z, Kaufman J, Schneider K, Liu L, Feng L, Schwartländer B - Vaccines (Basel) (2015)

Bottom Line: China's commitment to implementing established and emerging HIV/AIDS prevention and control strategies has led to substantial gains in terms of access to antiretroviral treatment and prevention services, but the evolving and multifaceted HIV/AIDS epidemic in China highlights the challenges of maintaining that response.This study presents modeling results exploring the potential impact of HIV vaccines in the Chinese context at varying efficacy and coverage rates, while further exploring the potential implications of vaccination programs aimed at reaching populations at highest risk of HIV infection.A preventive HIV vaccine would add a powerful tool to China's response, even if not 100% efficacious or available to the full population.

View Article: PubMed Central - PubMed

Affiliation: International AIDS Vaccine Initiative, 125 Broad St., 9th Floor, New York, NY 10004, USA. tharmon@iavi.org.

ABSTRACT
China's commitment to implementing established and emerging HIV/AIDS prevention and control strategies has led to substantial gains in terms of access to antiretroviral treatment and prevention services, but the evolving and multifaceted HIV/AIDS epidemic in China highlights the challenges of maintaining that response. This study presents modeling results exploring the potential impact of HIV vaccines in the Chinese context at varying efficacy and coverage rates, while further exploring the potential implications of vaccination programs aimed at reaching populations at highest risk of HIV infection. A preventive HIV vaccine would add a powerful tool to China's response, even if not 100% efficacious or available to the full population.

No MeSH data available.


Related in: MedlinePlus

Model Risk Structure.
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vaccines-03-00001-f005: Model Risk Structure.

Mentions: The model simulates HIV infection among adults age 15 to 49 using country-specific population data from variety of national sources and the United Nations Population Division. The population is divided by sex, but is not further stratified by age. People enter the model at age fifteen and are placed into one of five risk groups when they initiate sexual activity: (1) low-risk heterosexuals (monogamous partnership); (2) medium risk heterosexuals (multiple partners); (3) high risk heterosexuals (sex workers and their clients) (4) men who have sex with men (MSM); and (5) injecting drug users (IDUs). (Figure A1) An individual may leave any high-risk group by adopting lower risk behavior, and the model is able to capture this transition. Each person entering the model is assumed to be HIV negative until they become sexually active.


The Potential Impact of Preventive HIV Vaccines in China: Results and Benefits of a Multi-Province Modeling Collaboration.

Harmon T, Guo W, Stover J, Wu Z, Kaufman J, Schneider K, Liu L, Feng L, Schwartländer B - Vaccines (Basel) (2015)

Model Risk Structure.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494240&req=5

vaccines-03-00001-f005: Model Risk Structure.
Mentions: The model simulates HIV infection among adults age 15 to 49 using country-specific population data from variety of national sources and the United Nations Population Division. The population is divided by sex, but is not further stratified by age. People enter the model at age fifteen and are placed into one of five risk groups when they initiate sexual activity: (1) low-risk heterosexuals (monogamous partnership); (2) medium risk heterosexuals (multiple partners); (3) high risk heterosexuals (sex workers and their clients) (4) men who have sex with men (MSM); and (5) injecting drug users (IDUs). (Figure A1) An individual may leave any high-risk group by adopting lower risk behavior, and the model is able to capture this transition. Each person entering the model is assumed to be HIV negative until they become sexually active.

Bottom Line: China's commitment to implementing established and emerging HIV/AIDS prevention and control strategies has led to substantial gains in terms of access to antiretroviral treatment and prevention services, but the evolving and multifaceted HIV/AIDS epidemic in China highlights the challenges of maintaining that response.This study presents modeling results exploring the potential impact of HIV vaccines in the Chinese context at varying efficacy and coverage rates, while further exploring the potential implications of vaccination programs aimed at reaching populations at highest risk of HIV infection.A preventive HIV vaccine would add a powerful tool to China's response, even if not 100% efficacious or available to the full population.

View Article: PubMed Central - PubMed

Affiliation: International AIDS Vaccine Initiative, 125 Broad St., 9th Floor, New York, NY 10004, USA. tharmon@iavi.org.

ABSTRACT
China's commitment to implementing established and emerging HIV/AIDS prevention and control strategies has led to substantial gains in terms of access to antiretroviral treatment and prevention services, but the evolving and multifaceted HIV/AIDS epidemic in China highlights the challenges of maintaining that response. This study presents modeling results exploring the potential impact of HIV vaccines in the Chinese context at varying efficacy and coverage rates, while further exploring the potential implications of vaccination programs aimed at reaching populations at highest risk of HIV infection. A preventive HIV vaccine would add a powerful tool to China's response, even if not 100% efficacious or available to the full population.

No MeSH data available.


Related in: MedlinePlus