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Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification.

Huang ZH, Sun ZY, Gao Y, Chen PG, Liu YF, Chen YX, Li YM - Vaccines (Basel) (2014)

Bottom Line: However, the limitation of the specificity and efficiency of the synthetic tumor vaccines need further improvements.To overcome these difficulties, additional tumor-associated targets need to be identified, and optimized structural designs of vaccines need to be elaborated.In this review, we summarized the main strategies pursued in the design of synthetic tumor vaccines, such as multi-component, multivalency, antigen modification and other possible ways to improve the efficiency of synthetic tumor vaccines.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China. huangzh05@mails.tsinghua.edu.cn.

ABSTRACT
Synthetic tumor vaccines have been proven to be promising for cancer immunotherapy. However, the limitation of the specificity and efficiency of the synthetic tumor vaccines need further improvements. To overcome these difficulties, additional tumor-associated targets need to be identified, and optimized structural designs of vaccines need to be elaborated. In this review, we summarized the main strategies pursued in the design of synthetic tumor vaccines, such as multi-component, multivalency, antigen modification and other possible ways to improve the efficiency of synthetic tumor vaccines.

No MeSH data available.


The structure of a linear multivalent vaccine.
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vaccines-02-00549-f005: The structure of a linear multivalent vaccine.

Mentions: Danishyfsky and co-workers designed a vaccine containing several kinds of carbohydrate antigens of Globo-H, STn, Tn, Lewisy and TF in a linear backbone (Figure 5) [47,48,49,50]. In addition, a vaccine containing alternate Gb3 carbohydrate and an MUC5Ac T-helper cell epitope was designed to improve the immune response and specificity [51].


Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification.

Huang ZH, Sun ZY, Gao Y, Chen PG, Liu YF, Chen YX, Li YM - Vaccines (Basel) (2014)

The structure of a linear multivalent vaccine.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494217&req=5

vaccines-02-00549-f005: The structure of a linear multivalent vaccine.
Mentions: Danishyfsky and co-workers designed a vaccine containing several kinds of carbohydrate antigens of Globo-H, STn, Tn, Lewisy and TF in a linear backbone (Figure 5) [47,48,49,50]. In addition, a vaccine containing alternate Gb3 carbohydrate and an MUC5Ac T-helper cell epitope was designed to improve the immune response and specificity [51].

Bottom Line: However, the limitation of the specificity and efficiency of the synthetic tumor vaccines need further improvements.To overcome these difficulties, additional tumor-associated targets need to be identified, and optimized structural designs of vaccines need to be elaborated.In this review, we summarized the main strategies pursued in the design of synthetic tumor vaccines, such as multi-component, multivalency, antigen modification and other possible ways to improve the efficiency of synthetic tumor vaccines.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China. huangzh05@mails.tsinghua.edu.cn.

ABSTRACT
Synthetic tumor vaccines have been proven to be promising for cancer immunotherapy. However, the limitation of the specificity and efficiency of the synthetic tumor vaccines need further improvements. To overcome these difficulties, additional tumor-associated targets need to be identified, and optimized structural designs of vaccines need to be elaborated. In this review, we summarized the main strategies pursued in the design of synthetic tumor vaccines, such as multi-component, multivalency, antigen modification and other possible ways to improve the efficiency of synthetic tumor vaccines.

No MeSH data available.