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Effects of Ramadan fasting on glucose homeostasis and adiponectin levels in healthy adult males.

Gnanou JV, Caszo BA, Khalil KM, Abdullah SL, Knight VF, Bidin MZ - J Diabetes Metab Disord (2015)

Bottom Line: Subjects experienced a significant decrease in body weight (2.4 %, p < 0.001) and body mass index (5.5 %, p < 0.01).These results indicate that Ramadan fasting in young healthy individuals has a positive impact on the maintenance of glucose homeostasis.It also shows that adiponectin levels dropped along with significant loss in weight.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kem Sungai Besi, Kuala Lumpur, 57000 Malaysia.

ABSTRACT

Background: Adiponectin is a hormone secreted by adipocytes during the fasting phase of the fast-fed cycle. Ramadan fasting involves prolonged fasting for up to twelve hours and thus could lead to increased secretion of adiponectin by adipocytes. However, studies on the role of adiponectin on glucose and body weight homeostasis during Ramadan fasting is still a matter of controversy. Thus the specific aim of this study was to assess the effect of fasting during Ramadan on the adiponectin levels, body weight and glucose homeostasis in healthy male Malaysian subjects.

Methods: Twenty healthy male (19-23 years) Muslim subjects were followed up during the fasting month of Ramadan. Anthropometry and blood samples were taken one week before and during the fourth week of fasting. Plasma glucose, insulin and adiponectin were estimated and insulin sensitivity indices were estimated using the Homeostasis Model Assessment.

Results: Subjects experienced a significant decrease in body weight (2.4 %, p < 0.001) and body mass index (5.5 %, p < 0.01). There was also a significant decrease of 12.3 %, 52.8 % and 45.6 % of plasma glucose, insulin and adiponectin respectively (p < 0.01). The drop in adiponectin was positively correlated with the decrease in body weight (r = 0.45, p < 0.05). There was also a significant increase in insulin sensitivity and a decrease in insulin resistance (p < 0.01).

Conclusions: These results indicate that Ramadan fasting in young healthy individuals has a positive impact on the maintenance of glucose homeostasis. It also shows that adiponectin levels dropped along with significant loss in weight. We feel caloric restriction during the Ramadan fasting is in itself sufficient to improve insulin sensitivity in healthy individuals.

No MeSH data available.


Related in: MedlinePlus

Correlation between changes in plasma adiponectin and body weight during the four week fasting period. A significant correlation (r = 0.45, p < 0.05) was obtained showing an association between changes in plasma adiponectin and body weight after four weeks of fasting
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Fig3: Correlation between changes in plasma adiponectin and body weight during the four week fasting period. A significant correlation (r = 0.45, p < 0.05) was obtained showing an association between changes in plasma adiponectin and body weight after four weeks of fasting

Mentions: Four weeks after observing the Ramadan fast, a significant reduction (2.4 %) in body weight (p < 0.01) and also a significant reduction (5.5 %) in BMI (p < 0.01) were observed. There was also a significant reduction (3.2 %) in mid upper arm circumference (p < 0.01), however no difference in waist to hip ratio was observed (Table 1). In order to study the effect of Ramadan fasting on glucose homeostasis, plasma glucose and plasma insulin were measured. As shown in Fig. 1, there was a significant decrease in both the parameters (p < 0.01). There was also a significant increase in insulin sensitivity and a significant decrease in insulin resistance (p < 0.01). Finally, in order to study the role of adiponectin in intermittent fasting, plasma adiponectin was measured. We found a significant reduction in plasma adiponectin (Fig. 2) (p < 0.01). Findings from linear regression analysis revealed a significant positive correlation (r = 0.45, p < 0.05) between the change in plasma adiponectin and change in body weight due to the intermittent fasting (Fig. 3).Table 1


Effects of Ramadan fasting on glucose homeostasis and adiponectin levels in healthy adult males.

Gnanou JV, Caszo BA, Khalil KM, Abdullah SL, Knight VF, Bidin MZ - J Diabetes Metab Disord (2015)

Correlation between changes in plasma adiponectin and body weight during the four week fasting period. A significant correlation (r = 0.45, p < 0.05) was obtained showing an association between changes in plasma adiponectin and body weight after four weeks of fasting
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4494190&req=5

Fig3: Correlation between changes in plasma adiponectin and body weight during the four week fasting period. A significant correlation (r = 0.45, p < 0.05) was obtained showing an association between changes in plasma adiponectin and body weight after four weeks of fasting
Mentions: Four weeks after observing the Ramadan fast, a significant reduction (2.4 %) in body weight (p < 0.01) and also a significant reduction (5.5 %) in BMI (p < 0.01) were observed. There was also a significant reduction (3.2 %) in mid upper arm circumference (p < 0.01), however no difference in waist to hip ratio was observed (Table 1). In order to study the effect of Ramadan fasting on glucose homeostasis, plasma glucose and plasma insulin were measured. As shown in Fig. 1, there was a significant decrease in both the parameters (p < 0.01). There was also a significant increase in insulin sensitivity and a significant decrease in insulin resistance (p < 0.01). Finally, in order to study the role of adiponectin in intermittent fasting, plasma adiponectin was measured. We found a significant reduction in plasma adiponectin (Fig. 2) (p < 0.01). Findings from linear regression analysis revealed a significant positive correlation (r = 0.45, p < 0.05) between the change in plasma adiponectin and change in body weight due to the intermittent fasting (Fig. 3).Table 1

Bottom Line: Subjects experienced a significant decrease in body weight (2.4 %, p < 0.001) and body mass index (5.5 %, p < 0.01).These results indicate that Ramadan fasting in young healthy individuals has a positive impact on the maintenance of glucose homeostasis.It also shows that adiponectin levels dropped along with significant loss in weight.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kem Sungai Besi, Kuala Lumpur, 57000 Malaysia.

ABSTRACT

Background: Adiponectin is a hormone secreted by adipocytes during the fasting phase of the fast-fed cycle. Ramadan fasting involves prolonged fasting for up to twelve hours and thus could lead to increased secretion of adiponectin by adipocytes. However, studies on the role of adiponectin on glucose and body weight homeostasis during Ramadan fasting is still a matter of controversy. Thus the specific aim of this study was to assess the effect of fasting during Ramadan on the adiponectin levels, body weight and glucose homeostasis in healthy male Malaysian subjects.

Methods: Twenty healthy male (19-23 years) Muslim subjects were followed up during the fasting month of Ramadan. Anthropometry and blood samples were taken one week before and during the fourth week of fasting. Plasma glucose, insulin and adiponectin were estimated and insulin sensitivity indices were estimated using the Homeostasis Model Assessment.

Results: Subjects experienced a significant decrease in body weight (2.4 %, p < 0.001) and body mass index (5.5 %, p < 0.01). There was also a significant decrease of 12.3 %, 52.8 % and 45.6 % of plasma glucose, insulin and adiponectin respectively (p < 0.01). The drop in adiponectin was positively correlated with the decrease in body weight (r = 0.45, p < 0.05). There was also a significant increase in insulin sensitivity and a decrease in insulin resistance (p < 0.01).

Conclusions: These results indicate that Ramadan fasting in young healthy individuals has a positive impact on the maintenance of glucose homeostasis. It also shows that adiponectin levels dropped along with significant loss in weight. We feel caloric restriction during the Ramadan fasting is in itself sufficient to improve insulin sensitivity in healthy individuals.

No MeSH data available.


Related in: MedlinePlus