Limits...
Partial hepatectomy induces delayed hepatocyte proliferation and normal liver regeneration in ovariectomized mice.

Umeda M, Hiramoto M, Imai T - Clin Exp Gastroenterol (2015)

Bottom Line: Both E2 administration and PH induced the gene expression of estrogen receptor α (ERα).The transcripts of ERα were detected specifically in periportal hepatocytes after E2 administration and PH.Moreover, the E2 concentrations and hepatocyte proliferation rates were highest in the proestrus period of the estrous cycle.

View Article: PubMed Central - PubMed

Affiliation: Department of Aging Intervention, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.

ABSTRACT
Estrogens play central roles in sexual development, reproduction, and hepatocyte proliferation. The ovaries are one of the main organs for estradiol (E2) production. Ovariectomies (OVXs) were performed on the female mice, and hepatocyte proliferation was analyzed. The ovariectomized mice exhibited delayed hepatocyte proliferation after partial hepatectomy (PH) and also exhibited delayed and reduced E2 induction. Both E2 administration and PH induced the gene expression of estrogen receptor α (ERα). The transcripts of ERα were detected specifically in periportal hepatocytes after E2 administration and PH. Moreover, the E2 concentrations and hepatocyte proliferation rates were highest in the proestrus period of the estrous cycle. Taken together, these findings indicate that E2 accelerated ERα expression in periportal hepatocytes and hepatocyte proliferation in the female mice.

No MeSH data available.


Related in: MedlinePlus

Model of hepatocyte proliferation in female mice.Notes: PH (step 1a), the estrous cycle (step 1b), and E2 injection (step 1c) increased E2 concentrations (step 2), and ERα expression in the periportal hepatocytes was stimulated (step 3), which resulted in hepatocyte proliferation and LR.Abbreviations: PH, partial hepatectomy; E2, estradiol; ERα, estrogen receptor α; LR, liver regeneration.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4494181&req=5

f6-ceg-8-175: Model of hepatocyte proliferation in female mice.Notes: PH (step 1a), the estrous cycle (step 1b), and E2 injection (step 1c) increased E2 concentrations (step 2), and ERα expression in the periportal hepatocytes was stimulated (step 3), which resulted in hepatocyte proliferation and LR.Abbreviations: PH, partial hepatectomy; E2, estradiol; ERα, estrogen receptor α; LR, liver regeneration.

Mentions: The possible mechanisms of PH- and E2-induced hepatocyte proliferation were identified (Figure 6). PH (step 1a), the estrous cycle (step 1b), and E2 injection (step 1c) stimulated increases in E2 concentrations (step 2), ERα expression in the periportal hepatocytes (step 3), and hepatocyte proliferation.


Partial hepatectomy induces delayed hepatocyte proliferation and normal liver regeneration in ovariectomized mice.

Umeda M, Hiramoto M, Imai T - Clin Exp Gastroenterol (2015)

Model of hepatocyte proliferation in female mice.Notes: PH (step 1a), the estrous cycle (step 1b), and E2 injection (step 1c) increased E2 concentrations (step 2), and ERα expression in the periportal hepatocytes was stimulated (step 3), which resulted in hepatocyte proliferation and LR.Abbreviations: PH, partial hepatectomy; E2, estradiol; ERα, estrogen receptor α; LR, liver regeneration.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494181&req=5

f6-ceg-8-175: Model of hepatocyte proliferation in female mice.Notes: PH (step 1a), the estrous cycle (step 1b), and E2 injection (step 1c) increased E2 concentrations (step 2), and ERα expression in the periportal hepatocytes was stimulated (step 3), which resulted in hepatocyte proliferation and LR.Abbreviations: PH, partial hepatectomy; E2, estradiol; ERα, estrogen receptor α; LR, liver regeneration.
Mentions: The possible mechanisms of PH- and E2-induced hepatocyte proliferation were identified (Figure 6). PH (step 1a), the estrous cycle (step 1b), and E2 injection (step 1c) stimulated increases in E2 concentrations (step 2), ERα expression in the periportal hepatocytes (step 3), and hepatocyte proliferation.

Bottom Line: Both E2 administration and PH induced the gene expression of estrogen receptor α (ERα).The transcripts of ERα were detected specifically in periportal hepatocytes after E2 administration and PH.Moreover, the E2 concentrations and hepatocyte proliferation rates were highest in the proestrus period of the estrous cycle.

View Article: PubMed Central - PubMed

Affiliation: Department of Aging Intervention, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.

ABSTRACT
Estrogens play central roles in sexual development, reproduction, and hepatocyte proliferation. The ovaries are one of the main organs for estradiol (E2) production. Ovariectomies (OVXs) were performed on the female mice, and hepatocyte proliferation was analyzed. The ovariectomized mice exhibited delayed hepatocyte proliferation after partial hepatectomy (PH) and also exhibited delayed and reduced E2 induction. Both E2 administration and PH induced the gene expression of estrogen receptor α (ERα). The transcripts of ERα were detected specifically in periportal hepatocytes after E2 administration and PH. Moreover, the E2 concentrations and hepatocyte proliferation rates were highest in the proestrus period of the estrous cycle. Taken together, these findings indicate that E2 accelerated ERα expression in periportal hepatocytes and hepatocyte proliferation in the female mice.

No MeSH data available.


Related in: MedlinePlus