A New Class of SINEs with snRNA Gene-Derived Heads.
Bottom Line: SINEU-2 is the only SINE family that was active after the split of crocodiles and gharials.All SINEU families, especially SINEU-3, are preferentially inserted into a family of Mariner DNA transposon, Mariner-N4_AMi.A group of Tx1 non-long terminal repeat retrotransposons designated Tx1-Mar also show target preference for Mariner-N4_AMi, indicating that SINEU was mobilized by Tx1-Mar.
Affiliation: Genetic Information Research Institute, Los Altos, CA firstname.lastname@example.org.Show MeSH
Mentions: By the comparison of orthologous loci of crocodile and gharial, SINEU-2 insertions were found in the crocodile genome at whose orthologous loci in the gharial genome SINEU-2 are absent (fig. 2). Gharial-specific SINEU-2 insertions were also detected (supplementary fig. S2, Supplementary Material online). Both types of target site alterations (TSD and TST) were observed aside from the cases where no nucleotide was altered upon integration.Fig. 2.—
Affiliation: Genetic Information Research Institute, Los Altos, CA email@example.com.