A New Class of SINEs with snRNA Gene-Derived Heads.
Bottom Line: SINEU-2 is the only SINE family that was active after the split of crocodiles and gharials.All SINEU families, especially SINEU-3, are preferentially inserted into a family of Mariner DNA transposon, Mariner-N4_AMi.A group of Tx1 non-long terminal repeat retrotransposons designated Tx1-Mar also show target preference for Mariner-N4_AMi, indicating that SINEU was mobilized by Tx1-Mar.
Affiliation: Genetic Information Research Institute, Los Altos, CA firstname.lastname@example.org.Show MeSH
Mentions: From the characterization of transposable elements from the genomes of three species of crocodilians, A. mississippiensis, C. porosus, and G. gangeticus (Green et al. 2014), SINE families whose 5′ regions originated from either U1 or U2 snRNA genes were characterized. They are designated as SINEU and classified into three families (SINEU-1, SINEU-2, and SINEU-3) based on their structures (fig. 1). No SINEU families were detected outside of crocodilians. SINEU-1 was further classified into 11 subfamilies based on their structures and sequences. The 5′ ends of SINEU elements do not always correspond to the 5′ end of a U1 or U2 snRNA sequence; however, this might be an artifact from constructing consensus sequences from divergent copies. All groups of SINEU have 3′ polyA tail.Fig. 1.—
Affiliation: Genetic Information Research Institute, Los Altos, CA email@example.com.