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Comparison of the Venom Peptides and Their Expression in Closely Related Conus Species: Insights into Adaptive Post-speciation Evolution of Conus Exogenomes.

Barghi N, Concepcion GP, Olivera BM, Lluisma AO - Genome Biol Evol (2015)

Bottom Line: In this study, the sequences and expression levels of conotoxins from several specimens of two closely related worm-hunting species, Conus tribblei and Conus lenavati, were compared through transcriptome analysis.Comparison of the interspecific expression patterns of conopeptides at the superfamily level resulted in the discovery of both conserved as well as species-specific expression patterns, indicating divergence in the regulatory network affecting conotoxin gene expression.Comparison of the transcriptomes of the individual snails revealed that each specimen produces a distinct set of highly expressed conopeptides, reflecting the capability of individual snails to fine-tune the composition of their venoms.

View Article: PubMed Central - PubMed

Affiliation: Marine Science Institute, University of the Philippines-Diliman, Quezon City, Philippines.

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Distribution of the conopeptides in each gene superfamily based on the highest PID (the most similar match) of the conopeptides’ mature regions in C. tribblei and C. lenavati. The abbreviations of superfamily names are noted in figure 2.
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evv109-F5: Distribution of the conopeptides in each gene superfamily based on the highest PID (the most similar match) of the conopeptides’ mature regions in C. tribblei and C. lenavati. The abbreviations of superfamily names are noted in figure 2.

Mentions: Although, the total number of identified conopeptides in the lenavati conopeptide data set (132) was higher than in the tribblei conopeptide data set (100), the number of superfamilies in both species was similar (39–40 superfamilies). More than half of the conopeptides of the superfamilies shared in C. tribblei and C. lenavati had PID > 81%, and these sequences were distributed across all gene superfamilies (except for H-, S-, and F-superfamilies) (fig. 5). Additionally, 12.02% (12 superfamilies) and 8.65% (11 superfamilies) of conopeptides in C. tribblei and C. lenavati showed 61–80% and 41–60% PID, respectively. Interestingly, a large portion (19.71%) of conopeptides belonging to 12 gene superfamilies had only 21–40% PID. 2.88% of the conopeptides exhibited PID < 20%, whereas the minimum sequence identity was 10%.Fig. 5.—


Comparison of the Venom Peptides and Their Expression in Closely Related Conus Species: Insights into Adaptive Post-speciation Evolution of Conus Exogenomes.

Barghi N, Concepcion GP, Olivera BM, Lluisma AO - Genome Biol Evol (2015)

Distribution of the conopeptides in each gene superfamily based on the highest PID (the most similar match) of the conopeptides’ mature regions in C. tribblei and C. lenavati. The abbreviations of superfamily names are noted in figure 2.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494072&req=5

evv109-F5: Distribution of the conopeptides in each gene superfamily based on the highest PID (the most similar match) of the conopeptides’ mature regions in C. tribblei and C. lenavati. The abbreviations of superfamily names are noted in figure 2.
Mentions: Although, the total number of identified conopeptides in the lenavati conopeptide data set (132) was higher than in the tribblei conopeptide data set (100), the number of superfamilies in both species was similar (39–40 superfamilies). More than half of the conopeptides of the superfamilies shared in C. tribblei and C. lenavati had PID > 81%, and these sequences were distributed across all gene superfamilies (except for H-, S-, and F-superfamilies) (fig. 5). Additionally, 12.02% (12 superfamilies) and 8.65% (11 superfamilies) of conopeptides in C. tribblei and C. lenavati showed 61–80% and 41–60% PID, respectively. Interestingly, a large portion (19.71%) of conopeptides belonging to 12 gene superfamilies had only 21–40% PID. 2.88% of the conopeptides exhibited PID < 20%, whereas the minimum sequence identity was 10%.Fig. 5.—

Bottom Line: In this study, the sequences and expression levels of conotoxins from several specimens of two closely related worm-hunting species, Conus tribblei and Conus lenavati, were compared through transcriptome analysis.Comparison of the interspecific expression patterns of conopeptides at the superfamily level resulted in the discovery of both conserved as well as species-specific expression patterns, indicating divergence in the regulatory network affecting conotoxin gene expression.Comparison of the transcriptomes of the individual snails revealed that each specimen produces a distinct set of highly expressed conopeptides, reflecting the capability of individual snails to fine-tune the composition of their venoms.

View Article: PubMed Central - PubMed

Affiliation: Marine Science Institute, University of the Philippines-Diliman, Quezon City, Philippines.

Show MeSH
Related in: MedlinePlus