The evolutionary fate of alternatively spliced homologous exons after gene duplication.
Bottom Line: We found examples supporting two extreme evolutionary models for the behaviour of homologous axons after gene duplication.At other extreme, we identified genes in which the homologous exons were always conserved within paralogs, suggesting that the alternative splicing event cannot easily be separated from the function in these genes.That many homologous exons fall in between these two extremes highlights the diversity of biological systems and suggests that the subtle balance between alternative splicing and gene duplication is adjusted to the specific cellular context of each gene.
Affiliation: Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain email@example.com firstname.lastname@example.org.Show MeSH
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Mentions: The genes CACNA1C, CACNA1D, CACNA1S, and CACNA1F code for alpha subunits of voltage-gated calcium channels. These four paralogs form a monophyletic group that originated from GDs in the ancestor of jawed vertebrates. There are two pairs of MEHEs whose origin also dates back to the ancestor of vertebrates, but predating the GD events. The genes CACNA1C and CACNA1D both conserved the two pairs of ancestral MEHEs (fig. 6), whereas CACNA1F and CACNA1S experienced a process of loss/retention of different ancestral exons that, interestingly, affected the two pairs of MEHEs (fig. 6). CACNA1C presents an additional pair or MEHEs that may have evolved later in the ancestor of sarcopterygians, as it is conserved in coelacanth, Xenopus, and mammals.Fig. 6.—
Affiliation: Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain email@example.com firstname.lastname@example.org.