The evolutionary fate of alternatively spliced homologous exons after gene duplication.
Bottom Line: We found examples supporting two extreme evolutionary models for the behaviour of homologous axons after gene duplication.At other extreme, we identified genes in which the homologous exons were always conserved within paralogs, suggesting that the alternative splicing event cannot easily be separated from the function in these genes.That many homologous exons fall in between these two extremes highlights the diversity of biological systems and suggests that the subtle balance between alternative splicing and gene duplication is adjusted to the specific cellular context of each gene.
Affiliation: Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain firstname.lastname@example.org email@example.com.Show MeSH
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Mentions: The importance of AS is particularly clear in the case of human ACTN2 and ACTN4 genes, which code for alpha-actinin 2 and 4, respectively. Alpha-actinins are important cytoskeletal proteins with multiple roles and many interacting partners. Interestingly, some of these partners also have MEHEs, for example PDLIM3, with MEHEs that affect a region involved in actinin-binding. The actinin family has two pairs of MEHEs that are distant in sequence, but close in the dimeric structure (fig. 5B). In human, ACTN4 has both pairs of MEHEs, ACTN1 and ACTN2 each share a different pair of MEHEs with ACTN4, and ACTN3 has no MEHEs.Fig. 5.—
Affiliation: Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain firstname.lastname@example.org email@example.com.