The evolutionary fate of alternatively spliced homologous exons after gene duplication.
Bottom Line: We found examples supporting two extreme evolutionary models for the behaviour of homologous axons after gene duplication.At other extreme, we identified genes in which the homologous exons were always conserved within paralogs, suggesting that the alternative splicing event cannot easily be separated from the function in these genes.That many homologous exons fall in between these two extremes highlights the diversity of biological systems and suggests that the subtle balance between alternative splicing and gene duplication is adjusted to the specific cellular context of each gene.
Affiliation: Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain email@example.com firstname.lastname@example.org.Show MeSH
Related in: MedlinePlus
Mentions: Groups of Human Paralogs with Homologous Patterns of AS along with the Date of the Corresponding Duplication Events and the Relative Position of MEHEs within the Gene
Affiliation: Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain email@example.com firstname.lastname@example.org.