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The evolutionary fate of alternatively spliced homologous exons after gene duplication.

Abascal F, Tress ML, Valencia A - Genome Biol Evol (2015)

Bottom Line: We found examples supporting two extreme evolutionary models for the behaviour of homologous axons after gene duplication.At other extreme, we identified genes in which the homologous exons were always conserved within paralogs, suggesting that the alternative splicing event cannot easily be separated from the function in these genes.That many homologous exons fall in between these two extremes highlights the diversity of biological systems and suggests that the subtle balance between alternative splicing and gene duplication is adjusted to the specific cellular context of each gene.

View Article: PubMed Central - PubMed

Affiliation: Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain fabascal@cnio.es mtress@cnio.es.

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Related in: MedlinePlus

The 3D-structure of human MAPK8 (pdb code 3O17) is shown in (A) emphasizing the region corresponding to the MEHEs (blue), which of the residues coded by the MEHEs differ between alternative MAPK8 isoforms (purple) and the location of the active ATP-binding site (orange). (B) Direct comparison between the two alternative human MAPK8 isoforms (3O17 in blue, 1UKH in red), showing that most differences are found within the loop. (C) Multiple sequence alignment of MEHEs of JNKs (E6a and E6b in MAPK8), highlighting residues that are specifically conserved within each ancestral exon (blue dots) or that are conserved in one but variable in the other (orange dots).
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evv076-F4: The 3D-structure of human MAPK8 (pdb code 3O17) is shown in (A) emphasizing the region corresponding to the MEHEs (blue), which of the residues coded by the MEHEs differ between alternative MAPK8 isoforms (purple) and the location of the active ATP-binding site (orange). (B) Direct comparison between the two alternative human MAPK8 isoforms (3O17 in blue, 1UKH in red), showing that most differences are found within the loop. (C) Multiple sequence alignment of MEHEs of JNKs (E6a and E6b in MAPK8), highlighting residues that are specifically conserved within each ancestral exon (blue dots) or that are conserved in one but variable in the other (orange dots).

Mentions: Groups of Human Paralogs with Homologous Patterns of AS along with the Date of the Corresponding Duplication Events and the Relative Position of MEHEs within the Gene


The evolutionary fate of alternatively spliced homologous exons after gene duplication.

Abascal F, Tress ML, Valencia A - Genome Biol Evol (2015)

The 3D-structure of human MAPK8 (pdb code 3O17) is shown in (A) emphasizing the region corresponding to the MEHEs (blue), which of the residues coded by the MEHEs differ between alternative MAPK8 isoforms (purple) and the location of the active ATP-binding site (orange). (B) Direct comparison between the two alternative human MAPK8 isoforms (3O17 in blue, 1UKH in red), showing that most differences are found within the loop. (C) Multiple sequence alignment of MEHEs of JNKs (E6a and E6b in MAPK8), highlighting residues that are specifically conserved within each ancestral exon (blue dots) or that are conserved in one but variable in the other (orange dots).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494069&req=5

evv076-F4: The 3D-structure of human MAPK8 (pdb code 3O17) is shown in (A) emphasizing the region corresponding to the MEHEs (blue), which of the residues coded by the MEHEs differ between alternative MAPK8 isoforms (purple) and the location of the active ATP-binding site (orange). (B) Direct comparison between the two alternative human MAPK8 isoforms (3O17 in blue, 1UKH in red), showing that most differences are found within the loop. (C) Multiple sequence alignment of MEHEs of JNKs (E6a and E6b in MAPK8), highlighting residues that are specifically conserved within each ancestral exon (blue dots) or that are conserved in one but variable in the other (orange dots).
Mentions: Groups of Human Paralogs with Homologous Patterns of AS along with the Date of the Corresponding Duplication Events and the Relative Position of MEHEs within the Gene

Bottom Line: We found examples supporting two extreme evolutionary models for the behaviour of homologous axons after gene duplication.At other extreme, we identified genes in which the homologous exons were always conserved within paralogs, suggesting that the alternative splicing event cannot easily be separated from the function in these genes.That many homologous exons fall in between these two extremes highlights the diversity of biological systems and suggests that the subtle balance between alternative splicing and gene duplication is adjusted to the specific cellular context of each gene.

View Article: PubMed Central - PubMed

Affiliation: Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain fabascal@cnio.es mtress@cnio.es.

Show MeSH
Related in: MedlinePlus