The evolutionary fate of alternatively spliced homologous exons after gene duplication.
Bottom Line: We found examples supporting two extreme evolutionary models for the behaviour of homologous axons after gene duplication.At other extreme, we identified genes in which the homologous exons were always conserved within paralogs, suggesting that the alternative splicing event cannot easily be separated from the function in these genes.That many homologous exons fall in between these two extremes highlights the diversity of biological systems and suggests that the subtle balance between alternative splicing and gene duplication is adjusted to the specific cellular context of each gene.
Affiliation: Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain email@example.com firstname.lastname@example.org.Show MeSH
Related in: MedlinePlus
Mentions: For 84 of 97 genes we found that both MEHEs are present in at least one of the five target species (fig. 1 and supplementary table S1, Supplementary Material online). We determined that for almost all of the cases orthologous relationships could be established between each of the target MEHEs and each of the query MEHEs, implying that the large majority of MEHEs have not duplicated independently in different lineages (see supplementary material, Supplementary Material online). Hence, we can infer that these 84 MEHEs (or the majority of them) originated at least 400 Ma.Fig. 1.—
Affiliation: Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain email@example.com firstname.lastname@example.org.