Functionally Structured Genomes in Lactobacillus kunkeei Colonizing the Honey Crop and Food Products of Honeybees and Stingless Bees.
Bottom Line: A gene flux analysis, including previously sequenced Lactobacillus species as outgroups, indicated the influence of reductive evolution.We suggest that these features have resulted from a genome-wide loss of genes, with integrations of novel genes mostly occurring in regions flanking the origin of replication.The results provide an extended framework for reductive genome evolution and functional genome organization in bacteria.
Affiliation: Department of Molecular Evolution, Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Sweden.Show MeSH
Mentions: A similar bias was also observed for the recently acquired and variably present genes located near ori versus the conserved ancestral genes located near ter. Thus, 40 of the 50 genes present in all strains of L. kunkeei but in no other Lactobacillus genomes were flanking ori, of which 20 were clustered in a 100-kb segment (fig. 4). These genes were often of short, but similar sizes and showed atypically high sequence divergence levels between L. apinorum Fhon13 and the L. kunkeei strains.Fig. 4.—
Affiliation: Department of Molecular Evolution, Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Sweden.