The Rise and Fall of TRP-N, an Ancient Family of Mechanogated Ion Channels, in Metazoa.
Bottom Line: In flies, the transient-receptor-potential N protein (TRP-N) was found to be a cilia-associated mechanoreceptor.We propose that these new candidate proteins help explain the sensory complexity of Cnidaria which has been previously observed but so far has lacked a molecular underpinning.Also, the ancient appearance of TRP-N supports a common origin of important components of the nervous systems in Ctenophores, Cnidaria, and Bilateria.
Affiliation: Institute for Evolution and Biodiversity, University of Muenster, Germany.Show MeSH
Mentions: We used MUSCLE (Edgar 2004) to create a multiple sequence alignment of all TRP-N protein sequences mentioned in figure 2, except for the cnidarian ones for which it was a priori unknown whether they operate according to the push or pull mechanism. The resulting alignment was analyzed with JalView (Waterhouse et al. 2009; Troshin et al. 2011).Fig. 2.—
Affiliation: Institute for Evolution and Biodiversity, University of Muenster, Germany.