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Altered Cognitive Control Activations after Moderate-to-Severe Traumatic Brain Injury and Their Relationship to Injury Severity and Everyday-Life Function.

Olsen A, Brunner JF, Indredavik Evensen KA, Finnanger TG, Vik A, Skandsen T, Landrø NI, Håberg AK - Cereb. Cortex (2014)

Bottom Line: TBI survivors also had increased activations related to time-on-task effects during stable task-set maintenance in right inferior parietal and prefrontal cortices.In conclusion, evidence was provided that the neural underpinnings of adaptive and stable control processes are differently affected by TBI.Moreover, it was demonstrated that increased brain activations typically observed in survivors of TBI might represent injury-specific compensatory adaptations also utilized in everyday-life situations.

View Article: PubMed Central - PubMed

Affiliation: MI-Lab and Department of Circulation and Medical Imaging Department of Physical Medicine and Rehabilitation.

No MeSH data available.


Related in: MedlinePlus

Whole-brain TOT effects for stable task-set maintenance. SPMs are corrected for multiple comparisons using a cluster threshold of Z > 2.3, P = 0.05. Results are presented on a 1-mm MNI standard space template. SPM, Statistical Parametric Mapping; MNI, Montreal Neurological Institute.
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BHU023F2: Whole-brain TOT effects for stable task-set maintenance. SPMs are corrected for multiple comparisons using a cluster threshold of Z > 2.3, P = 0.05. Results are presented on a 1-mm MNI standard space template. SPM, Statistical Parametric Mapping; MNI, Montreal Neurological Institute.

Mentions: TBI survivors had statistically significant larger increase in activation as an effect of TOT for the stable task-set maintenance contrast in right parietal and frontal areas, as compared with healthy controls (Table 4, Fig. 2). The assumption of homogeneity of regression slopes was met for the MANCOVA used for further investigation of stable task-set maintenance TOT effects within ROIs, F9, 378 = 1.486, P = 0.151, and ηρ2 = 0.034. A significant main effect of group (healthy controls, moderate TBI, and severe TBI) was evident, F6, 236 = 2.210, P = 0.043, and ηρ2 = 0.053. This effect was driven by the effects of the right PFC ROI, F10, 119 = 2.523, P = 0.009, and ηρ2 = 0.175, as well as the right IPL ROI, F10, 119 = 2.919, P = 0.003, and ηρ2 = 0.197, whereas no statistically significant effect was present for the a priori chosen MFC ROI. Planned polynomial contrasts demonstrated that BOLD activation in the right PFC ROI (P = 0.002) and the right IPL (P = 0.001) were both linearly related to injury severity when adjusted for age, years of completed education, and Δ Not-X CPT measures (Fig. 1).Table 4


Altered Cognitive Control Activations after Moderate-to-Severe Traumatic Brain Injury and Their Relationship to Injury Severity and Everyday-Life Function.

Olsen A, Brunner JF, Indredavik Evensen KA, Finnanger TG, Vik A, Skandsen T, Landrø NI, Håberg AK - Cereb. Cortex (2014)

Whole-brain TOT effects for stable task-set maintenance. SPMs are corrected for multiple comparisons using a cluster threshold of Z > 2.3, P = 0.05. Results are presented on a 1-mm MNI standard space template. SPM, Statistical Parametric Mapping; MNI, Montreal Neurological Institute.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494028&req=5

BHU023F2: Whole-brain TOT effects for stable task-set maintenance. SPMs are corrected for multiple comparisons using a cluster threshold of Z > 2.3, P = 0.05. Results are presented on a 1-mm MNI standard space template. SPM, Statistical Parametric Mapping; MNI, Montreal Neurological Institute.
Mentions: TBI survivors had statistically significant larger increase in activation as an effect of TOT for the stable task-set maintenance contrast in right parietal and frontal areas, as compared with healthy controls (Table 4, Fig. 2). The assumption of homogeneity of regression slopes was met for the MANCOVA used for further investigation of stable task-set maintenance TOT effects within ROIs, F9, 378 = 1.486, P = 0.151, and ηρ2 = 0.034. A significant main effect of group (healthy controls, moderate TBI, and severe TBI) was evident, F6, 236 = 2.210, P = 0.043, and ηρ2 = 0.053. This effect was driven by the effects of the right PFC ROI, F10, 119 = 2.523, P = 0.009, and ηρ2 = 0.175, as well as the right IPL ROI, F10, 119 = 2.919, P = 0.003, and ηρ2 = 0.197, whereas no statistically significant effect was present for the a priori chosen MFC ROI. Planned polynomial contrasts demonstrated that BOLD activation in the right PFC ROI (P = 0.002) and the right IPL (P = 0.001) were both linearly related to injury severity when adjusted for age, years of completed education, and Δ Not-X CPT measures (Fig. 1).Table 4

Bottom Line: TBI survivors also had increased activations related to time-on-task effects during stable task-set maintenance in right inferior parietal and prefrontal cortices.In conclusion, evidence was provided that the neural underpinnings of adaptive and stable control processes are differently affected by TBI.Moreover, it was demonstrated that increased brain activations typically observed in survivors of TBI might represent injury-specific compensatory adaptations also utilized in everyday-life situations.

View Article: PubMed Central - PubMed

Affiliation: MI-Lab and Department of Circulation and Medical Imaging Department of Physical Medicine and Rehabilitation.

No MeSH data available.


Related in: MedlinePlus