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EpiFactors: a comprehensive database of human epigenetic factors and complexes.

Medvedeva YA, Lennartsson A, Ehsani R, Kulakovskiy IV, Vorontsov IE, Panahandeh P, Khimulya G, Kasukawa T, FANTOM ConsortiumDrabløs F - Database (Oxford) (2015)

Bottom Line: Rapidly growing knowledge in the area has resulted in the need for a resource that compiles, organizes and presents curated information to the researchers in an easily accessible and user-friendly form.EpiFactors also contains information on 69 protein complexes that are involved in epigenetic regulation.The resource is practical for a wide range of users, including biologists, pharmacologists and clinicians.

View Article: PubMed Central - PubMed

Affiliation: Institute of Personal and Predictive Medicine of Cancer, 08916 Badalona, Spain, Department of Computational Biology, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991 Moscow, Russia, ju.medvedeva@gmail.com.

No MeSH data available.


Related in: MedlinePlus

Interactive navigation figure for web page. Names of the histones andcomplexes are linked to the corresponding entities of the database. Sincecomplexes are represented by a group name, all complexes of the group willbe shown when the complex name is clicked on the website navigation figure.Complexes are located in the area corresponding to the shown function. Forexample CAF-1 (in lower right corner) participates in nucleosome assemblyafter replication.
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bav067-F1: Interactive navigation figure for web page. Names of the histones andcomplexes are linked to the corresponding entities of the database. Sincecomplexes are represented by a group name, all complexes of the group willbe shown when the complex name is clicked on the website navigation figure.Complexes are located in the area corresponding to the shown function. Forexample CAF-1 (in lower right corner) participates in nucleosome assemblyafter replication.

Mentions: EpiFactors is available online via a user-friendly web interfaceimplemented as a Ruby-on-Rails front-end with an SQLite back-end. The home pageprovides a graphical representation of epigenetic processes with all major elementsbeing ‘clickable’ and linked to the corresponding complex groups (Figure 1). The content of the database canalso be accessed through four specific tables: ‘Genes’,‘Complexes’, ‘Histones and protamines’,‘Expression’, either directly or by using keyword search. Each data tablecontains a customizable set of columns presenting information on respective entities.A user can also browse individual histones, protamines, epigenetic modifiers andtheir complexes. We also provide some general information in a ‘Docs’section of the website, to explain the resource structure and how it can be used.Figure 1.


EpiFactors: a comprehensive database of human epigenetic factors and complexes.

Medvedeva YA, Lennartsson A, Ehsani R, Kulakovskiy IV, Vorontsov IE, Panahandeh P, Khimulya G, Kasukawa T, FANTOM ConsortiumDrabløs F - Database (Oxford) (2015)

Interactive navigation figure for web page. Names of the histones andcomplexes are linked to the corresponding entities of the database. Sincecomplexes are represented by a group name, all complexes of the group willbe shown when the complex name is clicked on the website navigation figure.Complexes are located in the area corresponding to the shown function. Forexample CAF-1 (in lower right corner) participates in nucleosome assemblyafter replication.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4494013&req=5

bav067-F1: Interactive navigation figure for web page. Names of the histones andcomplexes are linked to the corresponding entities of the database. Sincecomplexes are represented by a group name, all complexes of the group willbe shown when the complex name is clicked on the website navigation figure.Complexes are located in the area corresponding to the shown function. Forexample CAF-1 (in lower right corner) participates in nucleosome assemblyafter replication.
Mentions: EpiFactors is available online via a user-friendly web interfaceimplemented as a Ruby-on-Rails front-end with an SQLite back-end. The home pageprovides a graphical representation of epigenetic processes with all major elementsbeing ‘clickable’ and linked to the corresponding complex groups (Figure 1). The content of the database canalso be accessed through four specific tables: ‘Genes’,‘Complexes’, ‘Histones and protamines’,‘Expression’, either directly or by using keyword search. Each data tablecontains a customizable set of columns presenting information on respective entities.A user can also browse individual histones, protamines, epigenetic modifiers andtheir complexes. We also provide some general information in a ‘Docs’section of the website, to explain the resource structure and how it can be used.Figure 1.

Bottom Line: Rapidly growing knowledge in the area has resulted in the need for a resource that compiles, organizes and presents curated information to the researchers in an easily accessible and user-friendly form.EpiFactors also contains information on 69 protein complexes that are involved in epigenetic regulation.The resource is practical for a wide range of users, including biologists, pharmacologists and clinicians.

View Article: PubMed Central - PubMed

Affiliation: Institute of Personal and Predictive Medicine of Cancer, 08916 Badalona, Spain, Department of Computational Biology, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991 Moscow, Russia, ju.medvedeva@gmail.com.

No MeSH data available.


Related in: MedlinePlus