Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves.
Bottom Line: Myelinophagy was positively regulated by the Schwann cell JNK/c-Jun pathway, a central regulator of the Schwann cell reprogramming induced by nerve injury.We also present evidence that myelinophagy is defective in the injured central nervous system.These results reveal an important role for inductive autophagy during Wallerian degeneration, and point to potential mechanistic targets for accelerating myelin clearance and improving demyelinating disease.
Affiliation: Department of Cell and Developmental Biology, University College London, London WC1E 6BT, England, UK.Show MeSH
Related in: MedlinePlus
License 1 - License 2
Mentions: To confirm that the Schwann cell autophagy machinery is selectively targeted to myelin during active digestion, electron microscopy of cultured nerve segments and Schwann cell cultures were performed. We found myelin debris clearly enclosed in double membrane vesicles typical of autophagosomes (Fig. 2). These observations show that autophagy is activated during Wallerian degeneration, specifically in demyelinating Schwann cells.
Affiliation: Department of Cell and Developmental Biology, University College London, London WC1E 6BT, England, UK.