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Co-enhancement of fluorescence and singlet oxygen generation by silica-coated gold nanorods core-shell nanoparticle.

Ke X, Wang D, Chen C, Yang A, Han Y, Ren L, Li D, Wang H - Nanoscale Res Lett (2014)

Bottom Line: Metal-enhanced fluorescence (MEF) as a newly recognized technology has been attracting considerable attention and is widely used in fluorescence-based technology.In this paper, we reported a novel distance-dependent MEF and metal-enhanced singlet oxygen generation phenomenon based on silica-coated gold nanorods (AuNRs@SiO2) core-shell structure with tetra-substituted carboxyl aluminum phthalocyanine (AlC4Pc) that serve as both fluorophore and photosensitizer.When the AlC4Pc was linked on the surface of AuNRs@SiO2, the fluorescence intensity and singlet oxygen productivity varied with the thickness difference of silica shell from 2.1 to 28.6 nm.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen, 361005, People's Republic of China, kcc2691@126.com.

ABSTRACT
Metal-enhanced fluorescence (MEF) as a newly recognized technology has been attracting considerable attention and is widely used in fluorescence-based technology. In this paper, we reported a novel distance-dependent MEF and metal-enhanced singlet oxygen generation phenomenon based on silica-coated gold nanorods (AuNRs@SiO2) core-shell structure with tetra-substituted carboxyl aluminum phthalocyanine (AlC4Pc) that serve as both fluorophore and photosensitizer. When the AlC4Pc was linked on the surface of AuNRs@SiO2, the fluorescence intensity and singlet oxygen productivity varied with the thickness difference of silica shell from 2.1 to 28.6 nm. The co-enhancement effect reached the maximum of 7-fold and 2.1-fold, respectively, when the separation distance was 10.6 nm. These unique characteristics make the prepared core-shell nanoparticles promising for MEF-based biological imaging and photodynamics therapy.

No MeSH data available.


Related in: MedlinePlus

Schematic Jablonski diagram for photosensitizer and mechanism of (a) metal-enhanced fluorescence and (b) singlet oxygen generation.
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Fig4: Schematic Jablonski diagram for photosensitizer and mechanism of (a) metal-enhanced fluorescence and (b) singlet oxygen generation.

Mentions: Previous reports have proposed that a remarkable fluorescence enhancement was achieved when the emission band of fluorophores overlapped with the SPR band of MEF substrate [28, 29]. For the mechanism of MEF, it was commonly accepted that the excited fluorophore energy could be transferred to the surface plasmon modes of metal and then partly be re-radiated to the far-field or be quenched by a non-radiative decay pathway when the energy of the light-emitting fluorophore and the surface plasmon energy of metal were match well [14, 29, 30]. It was worthy to notice that the fluorescence band of AlC4Pc overlapped well with the longitudinal SPR band of AuNRs. The maximum spectra matching between them could result in an efficient energy transfer, which might strongly meet the fundamental requirement of MEF (Figure 4a).Figure 4


Co-enhancement of fluorescence and singlet oxygen generation by silica-coated gold nanorods core-shell nanoparticle.

Ke X, Wang D, Chen C, Yang A, Han Y, Ren L, Li D, Wang H - Nanoscale Res Lett (2014)

Schematic Jablonski diagram for photosensitizer and mechanism of (a) metal-enhanced fluorescence and (b) singlet oxygen generation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493993&req=5

Fig4: Schematic Jablonski diagram for photosensitizer and mechanism of (a) metal-enhanced fluorescence and (b) singlet oxygen generation.
Mentions: Previous reports have proposed that a remarkable fluorescence enhancement was achieved when the emission band of fluorophores overlapped with the SPR band of MEF substrate [28, 29]. For the mechanism of MEF, it was commonly accepted that the excited fluorophore energy could be transferred to the surface plasmon modes of metal and then partly be re-radiated to the far-field or be quenched by a non-radiative decay pathway when the energy of the light-emitting fluorophore and the surface plasmon energy of metal were match well [14, 29, 30]. It was worthy to notice that the fluorescence band of AlC4Pc overlapped well with the longitudinal SPR band of AuNRs. The maximum spectra matching between them could result in an efficient energy transfer, which might strongly meet the fundamental requirement of MEF (Figure 4a).Figure 4

Bottom Line: Metal-enhanced fluorescence (MEF) as a newly recognized technology has been attracting considerable attention and is widely used in fluorescence-based technology.In this paper, we reported a novel distance-dependent MEF and metal-enhanced singlet oxygen generation phenomenon based on silica-coated gold nanorods (AuNRs@SiO2) core-shell structure with tetra-substituted carboxyl aluminum phthalocyanine (AlC4Pc) that serve as both fluorophore and photosensitizer.When the AlC4Pc was linked on the surface of AuNRs@SiO2, the fluorescence intensity and singlet oxygen productivity varied with the thickness difference of silica shell from 2.1 to 28.6 nm.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen, 361005, People's Republic of China, kcc2691@126.com.

ABSTRACT
Metal-enhanced fluorescence (MEF) as a newly recognized technology has been attracting considerable attention and is widely used in fluorescence-based technology. In this paper, we reported a novel distance-dependent MEF and metal-enhanced singlet oxygen generation phenomenon based on silica-coated gold nanorods (AuNRs@SiO2) core-shell structure with tetra-substituted carboxyl aluminum phthalocyanine (AlC4Pc) that serve as both fluorophore and photosensitizer. When the AlC4Pc was linked on the surface of AuNRs@SiO2, the fluorescence intensity and singlet oxygen productivity varied with the thickness difference of silica shell from 2.1 to 28.6 nm. The co-enhancement effect reached the maximum of 7-fold and 2.1-fold, respectively, when the separation distance was 10.6 nm. These unique characteristics make the prepared core-shell nanoparticles promising for MEF-based biological imaging and photodynamics therapy.

No MeSH data available.


Related in: MedlinePlus