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Co-enhancement of fluorescence and singlet oxygen generation by silica-coated gold nanorods core-shell nanoparticle.

Ke X, Wang D, Chen C, Yang A, Han Y, Ren L, Li D, Wang H - Nanoscale Res Lett (2014)

Bottom Line: Metal-enhanced fluorescence (MEF) as a newly recognized technology has been attracting considerable attention and is widely used in fluorescence-based technology.In this paper, we reported a novel distance-dependent MEF and metal-enhanced singlet oxygen generation phenomenon based on silica-coated gold nanorods (AuNRs@SiO2) core-shell structure with tetra-substituted carboxyl aluminum phthalocyanine (AlC4Pc) that serve as both fluorophore and photosensitizer.When the AlC4Pc was linked on the surface of AuNRs@SiO2, the fluorescence intensity and singlet oxygen productivity varied with the thickness difference of silica shell from 2.1 to 28.6 nm.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen, 361005, People's Republic of China, kcc2691@126.com.

ABSTRACT
Metal-enhanced fluorescence (MEF) as a newly recognized technology has been attracting considerable attention and is widely used in fluorescence-based technology. In this paper, we reported a novel distance-dependent MEF and metal-enhanced singlet oxygen generation phenomenon based on silica-coated gold nanorods (AuNRs@SiO2) core-shell structure with tetra-substituted carboxyl aluminum phthalocyanine (AlC4Pc) that serve as both fluorophore and photosensitizer. When the AlC4Pc was linked on the surface of AuNRs@SiO2, the fluorescence intensity and singlet oxygen productivity varied with the thickness difference of silica shell from 2.1 to 28.6 nm. The co-enhancement effect reached the maximum of 7-fold and 2.1-fold, respectively, when the separation distance was 10.6 nm. These unique characteristics make the prepared core-shell nanoparticles promising for MEF-based biological imaging and photodynamics therapy.

No MeSH data available.


Related in: MedlinePlus

Schematic description of the synthesis of AuNRs@SiO2-AlC4Pc.
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Fig1: Schematic description of the synthesis of AuNRs@SiO2-AlC4Pc.

Mentions: The formation process of AuNRs@SiO2-AlC4Pc was depicted in Figure 1. The size and morphology of samples were shown in Figure 2. The average length and diameter of AuNRs core were measured to be 46.8 ± 3.2 and 19.4 ± 1.1 nm. By simply varying the amount of added TEOS, uniform silica spacer shells with desired the thickness of 2.1, 6.2, 10.6, 14.7, 18.9, and 28.2 nm were synthesized, respectively (Figure 2a,b,c,d,e,f). The easily tunable feature of these amorphous silica shells would serve them well as spacer layer between the AuNRs and AlC4Pc to get an optimum fluorescence enhancement effect.Figure 1


Co-enhancement of fluorescence and singlet oxygen generation by silica-coated gold nanorods core-shell nanoparticle.

Ke X, Wang D, Chen C, Yang A, Han Y, Ren L, Li D, Wang H - Nanoscale Res Lett (2014)

Schematic description of the synthesis of AuNRs@SiO2-AlC4Pc.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493993&req=5

Fig1: Schematic description of the synthesis of AuNRs@SiO2-AlC4Pc.
Mentions: The formation process of AuNRs@SiO2-AlC4Pc was depicted in Figure 1. The size and morphology of samples were shown in Figure 2. The average length and diameter of AuNRs core were measured to be 46.8 ± 3.2 and 19.4 ± 1.1 nm. By simply varying the amount of added TEOS, uniform silica spacer shells with desired the thickness of 2.1, 6.2, 10.6, 14.7, 18.9, and 28.2 nm were synthesized, respectively (Figure 2a,b,c,d,e,f). The easily tunable feature of these amorphous silica shells would serve them well as spacer layer between the AuNRs and AlC4Pc to get an optimum fluorescence enhancement effect.Figure 1

Bottom Line: Metal-enhanced fluorescence (MEF) as a newly recognized technology has been attracting considerable attention and is widely used in fluorescence-based technology.In this paper, we reported a novel distance-dependent MEF and metal-enhanced singlet oxygen generation phenomenon based on silica-coated gold nanorods (AuNRs@SiO2) core-shell structure with tetra-substituted carboxyl aluminum phthalocyanine (AlC4Pc) that serve as both fluorophore and photosensitizer.When the AlC4Pc was linked on the surface of AuNRs@SiO2, the fluorescence intensity and singlet oxygen productivity varied with the thickness difference of silica shell from 2.1 to 28.6 nm.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen, 361005, People's Republic of China, kcc2691@126.com.

ABSTRACT
Metal-enhanced fluorescence (MEF) as a newly recognized technology has been attracting considerable attention and is widely used in fluorescence-based technology. In this paper, we reported a novel distance-dependent MEF and metal-enhanced singlet oxygen generation phenomenon based on silica-coated gold nanorods (AuNRs@SiO2) core-shell structure with tetra-substituted carboxyl aluminum phthalocyanine (AlC4Pc) that serve as both fluorophore and photosensitizer. When the AlC4Pc was linked on the surface of AuNRs@SiO2, the fluorescence intensity and singlet oxygen productivity varied with the thickness difference of silica shell from 2.1 to 28.6 nm. The co-enhancement effect reached the maximum of 7-fold and 2.1-fold, respectively, when the separation distance was 10.6 nm. These unique characteristics make the prepared core-shell nanoparticles promising for MEF-based biological imaging and photodynamics therapy.

No MeSH data available.


Related in: MedlinePlus