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The loss in expectation of life after colon cancer: a population-based study.

Andersson TM, Dickman PW, Eloranta S, Sjövall A, Lambe M, Lambert PC - BMC Cancer (2015)

Bottom Line: The pattern was similar for females, but slightly greater loss in expectation of life.The loss in expectation of life is reduced given survival up to a certain time point post diagnosis.Clear improvements in survival among colon cancer patients have led to a gain in life expectancy, partly due to a general increase in survival from all causes.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden. therese.m-l.andersson@ki.se.

ABSTRACT

Background: To demonstrate how assessment of life expectancy and loss in expectation of life can be used to address a wide range of research questions of public health interest pertaining to the prognosis of cancer patients.

Methods: We identified 135,092 cases of colon adenocarcinoma diagnosed during 1961-2011 from the population-based Swedish Cancer Register. Flexible parametric survival models for relative survival were used to estimate the life expectancy and the loss in expectation of life.

Results: The loss in expectation of life for males aged 55 at diagnosis was 13.5 years (95 % CI 13.2-13.8) in 1965 and 12.8 (12.4-13.3) in 2005. For males aged 85 the corresponding figures were 3.21 (3.15-3.28) and 2.10 (2.04-2.17). The pattern was similar for females, but slightly greater loss in expectation of life. The loss in expectation of life is reduced given survival up to a certain time point post diagnosis. Among patients diagnosed in 2011, 945 life years could potentially be saved if the colon cancer survival among males could be brought to the same level as for females.

Conclusion: Assessment of loss in expectation of life facilitates the understanding of the impact of cancer, both on individual and population level. Clear improvements in survival among colon cancer patients have led to a gain in life expectancy, partly due to a general increase in survival from all causes.

No MeSH data available.


Related in: MedlinePlus

Temporal trends in life expectancy from diagnosis for colon cancer patients diagnosed in Sweden during 1961–2011
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Fig1: Temporal trends in life expectancy from diagnosis for colon cancer patients diagnosed in Sweden during 1961–2011

Mentions: Figure 1 shows temporal trends in life expectancy from diagnosis for colon cancer patients and for a comparable disease-free general population. The difference between these two curves gives the loss in expectation of life. While the life expectancy for the colon cancer patients increased over calendar time, this increase mimics to a large extent the increase observed in the general population, and therefore the impact on the loss in expectation of life is modest (Table 2, Fig. 2). For example, for males aged 55 at diagnosis the loss in expectation of life was 13.5 years (95 % CI 13.2–13.8) in 1965 and 12.8 (12.4–13.3) in 2005. Female colon cancer patients have a better life expectancy than males, but since females in the general population have even higher life expectancy than males, the loss in expectation of life was greater among female patients.Fig. 1


The loss in expectation of life after colon cancer: a population-based study.

Andersson TM, Dickman PW, Eloranta S, Sjövall A, Lambe M, Lambert PC - BMC Cancer (2015)

Temporal trends in life expectancy from diagnosis for colon cancer patients diagnosed in Sweden during 1961–2011
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4493988&req=5

Fig1: Temporal trends in life expectancy from diagnosis for colon cancer patients diagnosed in Sweden during 1961–2011
Mentions: Figure 1 shows temporal trends in life expectancy from diagnosis for colon cancer patients and for a comparable disease-free general population. The difference between these two curves gives the loss in expectation of life. While the life expectancy for the colon cancer patients increased over calendar time, this increase mimics to a large extent the increase observed in the general population, and therefore the impact on the loss in expectation of life is modest (Table 2, Fig. 2). For example, for males aged 55 at diagnosis the loss in expectation of life was 13.5 years (95 % CI 13.2–13.8) in 1965 and 12.8 (12.4–13.3) in 2005. Female colon cancer patients have a better life expectancy than males, but since females in the general population have even higher life expectancy than males, the loss in expectation of life was greater among female patients.Fig. 1

Bottom Line: The pattern was similar for females, but slightly greater loss in expectation of life.The loss in expectation of life is reduced given survival up to a certain time point post diagnosis.Clear improvements in survival among colon cancer patients have led to a gain in life expectancy, partly due to a general increase in survival from all causes.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden. therese.m-l.andersson@ki.se.

ABSTRACT

Background: To demonstrate how assessment of life expectancy and loss in expectation of life can be used to address a wide range of research questions of public health interest pertaining to the prognosis of cancer patients.

Methods: We identified 135,092 cases of colon adenocarcinoma diagnosed during 1961-2011 from the population-based Swedish Cancer Register. Flexible parametric survival models for relative survival were used to estimate the life expectancy and the loss in expectation of life.

Results: The loss in expectation of life for males aged 55 at diagnosis was 13.5 years (95 % CI 13.2-13.8) in 1965 and 12.8 (12.4-13.3) in 2005. For males aged 85 the corresponding figures were 3.21 (3.15-3.28) and 2.10 (2.04-2.17). The pattern was similar for females, but slightly greater loss in expectation of life. The loss in expectation of life is reduced given survival up to a certain time point post diagnosis. Among patients diagnosed in 2011, 945 life years could potentially be saved if the colon cancer survival among males could be brought to the same level as for females.

Conclusion: Assessment of loss in expectation of life facilitates the understanding of the impact of cancer, both on individual and population level. Clear improvements in survival among colon cancer patients have led to a gain in life expectancy, partly due to a general increase in survival from all causes.

No MeSH data available.


Related in: MedlinePlus