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Depression increases the onset of cardiovascular disease over and above other determinants in older primary care patients, a cohort study.

van Marwijk HW, van der Kooy KG, Stehouwer CD, Beekman AT, van Hout HP - BMC Cardiovasc Disord (2015)

Bottom Line: MDD was associated with a hazard ratio of 2.83 (p value 0,004, 95% CI 1.32 to 6.05) for cardiovascular events.After adjustment for cardiovascular medication, the hazard ratio was 2.46 (95% CI 1.14 to 5.30).In a 2-year follow-up period, baseline MDD increased the risk for CVD in older primary care patients compared with controls, over and above well-known cardiovascular risk factors.

View Article: PubMed Central - PubMed

Affiliation: Department of General Practice and Elderly Care Medicine, EMGO+ Institute for Health and Health Care Research, VU University Medical Center, Amsterdam, The Netherlands. hwj.vanmarwijk@vumc.nl.

ABSTRACT

Background: To determine if major depressive disorder (MDD) in older primary care patients is an independent risk factor for cardiovascular events.

Methods: A cohort of 143 primary care patients with depression and 139 non-depressed controls without depression (both aged over 55 years, matched for age and gender) from the Netherlands was evaluated for 2 years. MDD was diagnosed according to DSM-IV-criteria. During the follow-up period, information was collected on physical health, depression status and behavioural risk factors. CVD end points were assessed with validated annual questionnaires and were crosschecked with medical records.

Results: Thirty-four participants experienced a cardiovascular event, of which 71% were depressed: 27/134 with MDD (20.1%) and 9/137 controls (6.6%). MDD was associated with a hazard ratio of 2.83 (p value 0,004, 95% CI 1.32 to 6.05) for cardiovascular events. After adjustment for cardiovascular medication, the hazard ratio was 2.46 (95% CI 1.14 to 5.30).

Conclusions: In a 2-year follow-up period, baseline MDD increased the risk for CVD in older primary care patients compared with controls, over and above well-known cardiovascular risk factors.

No MeSH data available.


Related in: MedlinePlus

The cumulative survival of controls and depressed cases over a 2 year follow-up
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Fig1: The cumulative survival of controls and depressed cases over a 2 year follow-up

Mentions: A total of 6719 persons was screened for depressive symptoms using the GDS-15. Of the approached GP patients, 293 were identified to have MDD. Of these patients, 187 were eligible and 76 % of them participated in our study (n = 143). The non-participants (ineligible, refused) had a comparable gender distribution (66.7 vs. 64.0 % female), but were older (71.55 vs. 67.59 years) and had a lower average PRIME-MD score (5.86 vs. 6.37) than the 143 participating index participants. Fig. 1 presents a flowchart of the recruitment.Fig. 1


Depression increases the onset of cardiovascular disease over and above other determinants in older primary care patients, a cohort study.

van Marwijk HW, van der Kooy KG, Stehouwer CD, Beekman AT, van Hout HP - BMC Cardiovasc Disord (2015)

The cumulative survival of controls and depressed cases over a 2 year follow-up
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4493948&req=5

Fig1: The cumulative survival of controls and depressed cases over a 2 year follow-up
Mentions: A total of 6719 persons was screened for depressive symptoms using the GDS-15. Of the approached GP patients, 293 were identified to have MDD. Of these patients, 187 were eligible and 76 % of them participated in our study (n = 143). The non-participants (ineligible, refused) had a comparable gender distribution (66.7 vs. 64.0 % female), but were older (71.55 vs. 67.59 years) and had a lower average PRIME-MD score (5.86 vs. 6.37) than the 143 participating index participants. Fig. 1 presents a flowchart of the recruitment.Fig. 1

Bottom Line: MDD was associated with a hazard ratio of 2.83 (p value 0,004, 95% CI 1.32 to 6.05) for cardiovascular events.After adjustment for cardiovascular medication, the hazard ratio was 2.46 (95% CI 1.14 to 5.30).In a 2-year follow-up period, baseline MDD increased the risk for CVD in older primary care patients compared with controls, over and above well-known cardiovascular risk factors.

View Article: PubMed Central - PubMed

Affiliation: Department of General Practice and Elderly Care Medicine, EMGO+ Institute for Health and Health Care Research, VU University Medical Center, Amsterdam, The Netherlands. hwj.vanmarwijk@vumc.nl.

ABSTRACT

Background: To determine if major depressive disorder (MDD) in older primary care patients is an independent risk factor for cardiovascular events.

Methods: A cohort of 143 primary care patients with depression and 139 non-depressed controls without depression (both aged over 55 years, matched for age and gender) from the Netherlands was evaluated for 2 years. MDD was diagnosed according to DSM-IV-criteria. During the follow-up period, information was collected on physical health, depression status and behavioural risk factors. CVD end points were assessed with validated annual questionnaires and were crosschecked with medical records.

Results: Thirty-four participants experienced a cardiovascular event, of which 71% were depressed: 27/134 with MDD (20.1%) and 9/137 controls (6.6%). MDD was associated with a hazard ratio of 2.83 (p value 0,004, 95% CI 1.32 to 6.05) for cardiovascular events. After adjustment for cardiovascular medication, the hazard ratio was 2.46 (95% CI 1.14 to 5.30).

Conclusions: In a 2-year follow-up period, baseline MDD increased the risk for CVD in older primary care patients compared with controls, over and above well-known cardiovascular risk factors.

No MeSH data available.


Related in: MedlinePlus