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Interaction of physical function, quality of life and depression in Amyotrophic lateral sclerosis: characterization of a large patient cohort.

Körner S, Kollewe K, Abdulla S, Zapf A, Dengler R, Petri S - BMC Neurol (2015)

Bottom Line: QoL of ALS patients was reduced in nearly all SF-36-categories.Regarding distinct patient characteristics one of the most interesting findings was that increasing age was correlated with significantly worse QoL results regarding social functioning.Being aware of these differences can be valuable for both ALS professional and family caregivers and physicians.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. Koerner.Sonja@mh-hannover.de.

ABSTRACT

Background: Due to lack of any curative therapy for ALS, symptomatic treatment and maintenance of quality of life (QoL) is very important. We aimed to characterize the affected domains of QoL in ALS patients and to identify factors which are associated with reduced QoL and increased depression.

Methods: 159 ALS patients answered standardized questionnaires (Beck Depression Inventory-II, SF-36 Health Survey questionnaire, revised ALS functional rating scale). Multiple regression analysis was used to identify correlations between clinical features of ALS patients and depression/QoL scores. In addition, QoL data from ALS patients were compared to age-matched reference values representing the German normal population.

Results: QoL of ALS patients was reduced in nearly all SF-36-categories. Progression of physical impairment was positively correlated with depression but reduced QoL scores only in items directly related to physical function. However, QoL was considerably influenced by depression, independently from physical impairment. Regarding distinct patient characteristics one of the most interesting findings was that increasing age was correlated with significantly worse QoL results regarding social functioning.

Conclusions: Depressive symptoms had a strong influence on QoL, hence their detection and treatment is of particular importance. Different domains of QoL are differently affected in subgroups of ALS patients. Being aware of these differences can be valuable for both ALS professional and family caregivers and physicians.

No MeSH data available.


Related in: MedlinePlus

Comparison of quality of life (QoL) in ALS patients to age-group specific reference values of the German general population. QoL is declined in ALS patients in nearly every scale. Limitations in the field “mental health” only become apparent in older patients, and in the subscale “bodily pain” QoL of ALS patients barely differs from the general population. As in the scales “Physical Functioning”, “Physical Role”, “Bodily Pain” and “Emotional Role” a normal distribution cannot be assumed the comparison in these fields can only be rated descriptive. Sample sizes: 31–40 years 5 patients, 41–50 years 22 patients, 51–60 years 53 patients, 61–70 years 42 patients, >70 years 37 patients
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Fig1: Comparison of quality of life (QoL) in ALS patients to age-group specific reference values of the German general population. QoL is declined in ALS patients in nearly every scale. Limitations in the field “mental health” only become apparent in older patients, and in the subscale “bodily pain” QoL of ALS patients barely differs from the general population. As in the scales “Physical Functioning”, “Physical Role”, “Bodily Pain” and “Emotional Role” a normal distribution cannot be assumed the comparison in these fields can only be rated descriptive. Sample sizes: 31–40 years 5 patients, 41–50 years 22 patients, 51–60 years 53 patients, 61–70 years 42 patients, >70 years 37 patients

Mentions: Compared to the German general population in age-matched groups, QoL was significantly reduced in our ALS patient cohort in all categories represented by the SF-36 subscales except for the item “Bodily pain” where ALS patients only marginally differed from the general population. Differences related to “mental health” seemed to be only relevant in older patients (older than 51 years) (Fig. 1).Fig. 1


Interaction of physical function, quality of life and depression in Amyotrophic lateral sclerosis: characterization of a large patient cohort.

Körner S, Kollewe K, Abdulla S, Zapf A, Dengler R, Petri S - BMC Neurol (2015)

Comparison of quality of life (QoL) in ALS patients to age-group specific reference values of the German general population. QoL is declined in ALS patients in nearly every scale. Limitations in the field “mental health” only become apparent in older patients, and in the subscale “bodily pain” QoL of ALS patients barely differs from the general population. As in the scales “Physical Functioning”, “Physical Role”, “Bodily Pain” and “Emotional Role” a normal distribution cannot be assumed the comparison in these fields can only be rated descriptive. Sample sizes: 31–40 years 5 patients, 41–50 years 22 patients, 51–60 years 53 patients, 61–70 years 42 patients, >70 years 37 patients
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4493831&req=5

Fig1: Comparison of quality of life (QoL) in ALS patients to age-group specific reference values of the German general population. QoL is declined in ALS patients in nearly every scale. Limitations in the field “mental health” only become apparent in older patients, and in the subscale “bodily pain” QoL of ALS patients barely differs from the general population. As in the scales “Physical Functioning”, “Physical Role”, “Bodily Pain” and “Emotional Role” a normal distribution cannot be assumed the comparison in these fields can only be rated descriptive. Sample sizes: 31–40 years 5 patients, 41–50 years 22 patients, 51–60 years 53 patients, 61–70 years 42 patients, >70 years 37 patients
Mentions: Compared to the German general population in age-matched groups, QoL was significantly reduced in our ALS patient cohort in all categories represented by the SF-36 subscales except for the item “Bodily pain” where ALS patients only marginally differed from the general population. Differences related to “mental health” seemed to be only relevant in older patients (older than 51 years) (Fig. 1).Fig. 1

Bottom Line: QoL of ALS patients was reduced in nearly all SF-36-categories.Regarding distinct patient characteristics one of the most interesting findings was that increasing age was correlated with significantly worse QoL results regarding social functioning.Being aware of these differences can be valuable for both ALS professional and family caregivers and physicians.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. Koerner.Sonja@mh-hannover.de.

ABSTRACT

Background: Due to lack of any curative therapy for ALS, symptomatic treatment and maintenance of quality of life (QoL) is very important. We aimed to characterize the affected domains of QoL in ALS patients and to identify factors which are associated with reduced QoL and increased depression.

Methods: 159 ALS patients answered standardized questionnaires (Beck Depression Inventory-II, SF-36 Health Survey questionnaire, revised ALS functional rating scale). Multiple regression analysis was used to identify correlations between clinical features of ALS patients and depression/QoL scores. In addition, QoL data from ALS patients were compared to age-matched reference values representing the German normal population.

Results: QoL of ALS patients was reduced in nearly all SF-36-categories. Progression of physical impairment was positively correlated with depression but reduced QoL scores only in items directly related to physical function. However, QoL was considerably influenced by depression, independently from physical impairment. Regarding distinct patient characteristics one of the most interesting findings was that increasing age was correlated with significantly worse QoL results regarding social functioning.

Conclusions: Depressive symptoms had a strong influence on QoL, hence their detection and treatment is of particular importance. Different domains of QoL are differently affected in subgroups of ALS patients. Being aware of these differences can be valuable for both ALS professional and family caregivers and physicians.

No MeSH data available.


Related in: MedlinePlus