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Reduced cortical thickness in right Heschl's gyrus associated with auditory verbal hallucinations severity in first-episode schizophrenia.

Chen X, Liang S, Pu W, Song Y, Mwansisya TE, Yang Q, Liu H, Liu Z, Shan B, Xue Z - BMC Psychiatry (2015)

Bottom Line: The severity of AVHs was rated by the Auditory Hallucinations Rating Scale (AHRS).Compared to both HCs and NH patients, AH patients showed lower cortical thickness in the right Heschl's gyrus.The degree of reduction in the cortical thickness was correlated with AVH severity in the AH patients.

View Article: PubMed Central - PubMed

Affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, 410011, People's Republic of China. 15874189941@163.com.

ABSTRACT

Background: Auditory verbal hallucinations (AVHs) represent one of the most intriguing phenomena in schizophrenia, however, brain abnormalities underlying AVHs remain unclear. The present study examined the association between cortical thickness and AVHs in first-episode schizophrenia.

Method: High-resolution MR images were obtained in 49 first-episode schizophrenia (FES) patients and 50 well-matched healthy controls (HCs). Among the FES patients, 18 suffered persistent AVHs ("auditory hallucination" AH group), and 31 never experienced AVHs ("no hallucination" NH group). The severity of AVHs was rated by the Auditory Hallucinations Rating Scale (AHRS). Cortical thickness differences among the three groups and their association with AVHs severity were examined.

Results: Compared to both HCs and NH patients, AH patients showed lower cortical thickness in the right Heschl's gyrus. The degree of reduction in the cortical thickness was correlated with AVH severity in the AH patients.

Conclusions: Abnormalities of cortical thickness in the Heschl's gyrus may be a physiological factor underlying auditory verbal hallucinations in schizophrenia.

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Related in: MedlinePlus

Cortical thickness analysis among patients and healthy controls groups. a Significant differences among groups were identified using ANCOVA with age and sex as covariates (* p < .05, corrected for multiple comparisons with LSD). The right Heschl’s gyrus (labeled in green) showed significant difference in cortical thickness among three groups. (AH < NH, HC, AH = Hallucinating patients with schizophrenia, NH = Non-hallucinating patients with schizophrenia, HC = Healthy controls. Error bars represent SDs). b The cortical thickness of right Heschl’s gyrus was negatively correlated with the severity of auditory verbal hallucinations, as assessed by AHRS scores
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Fig1: Cortical thickness analysis among patients and healthy controls groups. a Significant differences among groups were identified using ANCOVA with age and sex as covariates (* p < .05, corrected for multiple comparisons with LSD). The right Heschl’s gyrus (labeled in green) showed significant difference in cortical thickness among three groups. (AH < NH, HC, AH = Hallucinating patients with schizophrenia, NH = Non-hallucinating patients with schizophrenia, HC = Healthy controls. Error bars represent SDs). b The cortical thickness of right Heschl’s gyrus was negatively correlated with the severity of auditory verbal hallucinations, as assessed by AHRS scores

Mentions: Group ANCOVA analysis demonstrated that only the right transverse temporal cortex (Heschl’s gyrus) showed significant difference in cortical thickness among the three groups (F = 6.06 p < .05; see Table 2 and Additional file 1: Table S1). Post-hoc comparisons showed that the right HG cortical thickness was significantly reduced in the AH patients compared to that of the NH patients as well as the HCs (p < .05, corrected for multiple comparisons with LSD; see Table 2, Fig. 1)Table 2


Reduced cortical thickness in right Heschl's gyrus associated with auditory verbal hallucinations severity in first-episode schizophrenia.

Chen X, Liang S, Pu W, Song Y, Mwansisya TE, Yang Q, Liu H, Liu Z, Shan B, Xue Z - BMC Psychiatry (2015)

Cortical thickness analysis among patients and healthy controls groups. a Significant differences among groups were identified using ANCOVA with age and sex as covariates (* p < .05, corrected for multiple comparisons with LSD). The right Heschl’s gyrus (labeled in green) showed significant difference in cortical thickness among three groups. (AH < NH, HC, AH = Hallucinating patients with schizophrenia, NH = Non-hallucinating patients with schizophrenia, HC = Healthy controls. Error bars represent SDs). b The cortical thickness of right Heschl’s gyrus was negatively correlated with the severity of auditory verbal hallucinations, as assessed by AHRS scores
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4493802&req=5

Fig1: Cortical thickness analysis among patients and healthy controls groups. a Significant differences among groups were identified using ANCOVA with age and sex as covariates (* p < .05, corrected for multiple comparisons with LSD). The right Heschl’s gyrus (labeled in green) showed significant difference in cortical thickness among three groups. (AH < NH, HC, AH = Hallucinating patients with schizophrenia, NH = Non-hallucinating patients with schizophrenia, HC = Healthy controls. Error bars represent SDs). b The cortical thickness of right Heschl’s gyrus was negatively correlated with the severity of auditory verbal hallucinations, as assessed by AHRS scores
Mentions: Group ANCOVA analysis demonstrated that only the right transverse temporal cortex (Heschl’s gyrus) showed significant difference in cortical thickness among the three groups (F = 6.06 p < .05; see Table 2 and Additional file 1: Table S1). Post-hoc comparisons showed that the right HG cortical thickness was significantly reduced in the AH patients compared to that of the NH patients as well as the HCs (p < .05, corrected for multiple comparisons with LSD; see Table 2, Fig. 1)Table 2

Bottom Line: The severity of AVHs was rated by the Auditory Hallucinations Rating Scale (AHRS).Compared to both HCs and NH patients, AH patients showed lower cortical thickness in the right Heschl's gyrus.The degree of reduction in the cortical thickness was correlated with AVH severity in the AH patients.

View Article: PubMed Central - PubMed

Affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, 410011, People's Republic of China. 15874189941@163.com.

ABSTRACT

Background: Auditory verbal hallucinations (AVHs) represent one of the most intriguing phenomena in schizophrenia, however, brain abnormalities underlying AVHs remain unclear. The present study examined the association between cortical thickness and AVHs in first-episode schizophrenia.

Method: High-resolution MR images were obtained in 49 first-episode schizophrenia (FES) patients and 50 well-matched healthy controls (HCs). Among the FES patients, 18 suffered persistent AVHs ("auditory hallucination" AH group), and 31 never experienced AVHs ("no hallucination" NH group). The severity of AVHs was rated by the Auditory Hallucinations Rating Scale (AHRS). Cortical thickness differences among the three groups and their association with AVHs severity were examined.

Results: Compared to both HCs and NH patients, AH patients showed lower cortical thickness in the right Heschl's gyrus. The degree of reduction in the cortical thickness was correlated with AVH severity in the AH patients.

Conclusions: Abnormalities of cortical thickness in the Heschl's gyrus may be a physiological factor underlying auditory verbal hallucinations in schizophrenia.

Show MeSH
Related in: MedlinePlus