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Ultrasound measurement of optic nerve diameter and optic nerve sheath diameter in healthy Chinese adults.

Chen H, Ding GS, Zhao YC, Yu RG, Zhou JX - BMC Neurol (2015)

Bottom Line: There was no significant difference in ETD, OND or ONSD between male and female, or between left and right eye.ONSD was significantly correlated with OND (r = 0.62, P < 0.001), and the median OND/ONSD ratio (interquartile range) was 0.63 (0.59 to 0.67).The median OND/ONSD ratio is 0.63 and this parameter warrants further investigation in patients with brain injury.

View Article: PubMed Central - PubMed

Affiliation: Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, No 6, TiantanXili, Dongcheng District, Beijing, 100050, China. baojr2@163.com.

ABSTRACT

Background: Measurement of optic nerve sheath diameter (ONSD) is a fast and non-invasive method in detecting elevated intracranial pressure. However, the reported normal range of ONSD was inconsistent. The objective of the study was to determine the normal range of ONSD in healthy Chinese adults.

Methods: Eyeball transverse diameter (ETD), optic nerve diameter (OND), and ONSD were measured by ultrasound examination in healthy adult volunteers. The OND and ONSD were assessed 3 mm behind the globe. The section showing maximal transverse diameter of the eyeball was frozen and the diameter was measured. Each ETD, OND and ONSD was examined twice and the mean value was calculated.

Results: A total of 519 healthy volunteers were included in the study. The median (interquartile range) of ETD, OND and ONSD were 22.3 (21.6 to 23.1) mm, 3.2 (2.9 to 3.4) mm, and 5.1 (4.7 to 5.4) mm, respectively. The 95% percentile of ONSD was 5.9 mm. There was no significant difference in ETD, OND or ONSD between male and female, or between left and right eye. ONSD was significantly correlated with OND (r = 0.62, P < 0.001), and the median OND/ONSD ratio (interquartile range) was 0.63 (0.59 to 0.67).

Conclusions: The median and the 95% percentile of sonographic measurement of ONSD are 5.1 mm and 5.9 mm in healthy Chinese adults. The ONSD is correlated with OND, while independent of gender, age, height, weight and ETD. The median OND/ONSD ratio is 0.63 and this parameter warrants further investigation in patients with brain injury.

No MeSH data available.


Related in: MedlinePlus

Box plot of the ONSD of different heights. Compared by Kruskal-Wallis test, P = 0.109
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Fig3: Box plot of the ONSD of different heights. Compared by Kruskal-Wallis test, P = 0.109

Mentions: There was no significant difference in ETD, OND and ONSD between the male and female, or between the left and right eye (Table 2). ONSD was significantly correlated with OND (r = 0.62, P < 0.001). The median OND/ONSD ratio (IQR) was 0.63 (0.59 to 0.67). Although a statistically significant correlation was found between ONSD and height, the correlation coefficient was sub-optimal (r = 0.063, P = 0.041). Therefore we compared the ONSD between different height and no difference was observed (P = 0.109, Fig. 3). There was no linear relationship of ONSD with ETD (r = 0.044, P = 0.155), with age (r = 0.023, P = 0.467), or with weight (r = −0.005, P = 0.866).Table 2


Ultrasound measurement of optic nerve diameter and optic nerve sheath diameter in healthy Chinese adults.

Chen H, Ding GS, Zhao YC, Yu RG, Zhou JX - BMC Neurol (2015)

Box plot of the ONSD of different heights. Compared by Kruskal-Wallis test, P = 0.109
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4493801&req=5

Fig3: Box plot of the ONSD of different heights. Compared by Kruskal-Wallis test, P = 0.109
Mentions: There was no significant difference in ETD, OND and ONSD between the male and female, or between the left and right eye (Table 2). ONSD was significantly correlated with OND (r = 0.62, P < 0.001). The median OND/ONSD ratio (IQR) was 0.63 (0.59 to 0.67). Although a statistically significant correlation was found between ONSD and height, the correlation coefficient was sub-optimal (r = 0.063, P = 0.041). Therefore we compared the ONSD between different height and no difference was observed (P = 0.109, Fig. 3). There was no linear relationship of ONSD with ETD (r = 0.044, P = 0.155), with age (r = 0.023, P = 0.467), or with weight (r = −0.005, P = 0.866).Table 2

Bottom Line: There was no significant difference in ETD, OND or ONSD between male and female, or between left and right eye.ONSD was significantly correlated with OND (r = 0.62, P < 0.001), and the median OND/ONSD ratio (interquartile range) was 0.63 (0.59 to 0.67).The median OND/ONSD ratio is 0.63 and this parameter warrants further investigation in patients with brain injury.

View Article: PubMed Central - PubMed

Affiliation: Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, No 6, TiantanXili, Dongcheng District, Beijing, 100050, China. baojr2@163.com.

ABSTRACT

Background: Measurement of optic nerve sheath diameter (ONSD) is a fast and non-invasive method in detecting elevated intracranial pressure. However, the reported normal range of ONSD was inconsistent. The objective of the study was to determine the normal range of ONSD in healthy Chinese adults.

Methods: Eyeball transverse diameter (ETD), optic nerve diameter (OND), and ONSD were measured by ultrasound examination in healthy adult volunteers. The OND and ONSD were assessed 3 mm behind the globe. The section showing maximal transverse diameter of the eyeball was frozen and the diameter was measured. Each ETD, OND and ONSD was examined twice and the mean value was calculated.

Results: A total of 519 healthy volunteers were included in the study. The median (interquartile range) of ETD, OND and ONSD were 22.3 (21.6 to 23.1) mm, 3.2 (2.9 to 3.4) mm, and 5.1 (4.7 to 5.4) mm, respectively. The 95% percentile of ONSD was 5.9 mm. There was no significant difference in ETD, OND or ONSD between male and female, or between left and right eye. ONSD was significantly correlated with OND (r = 0.62, P < 0.001), and the median OND/ONSD ratio (interquartile range) was 0.63 (0.59 to 0.67).

Conclusions: The median and the 95% percentile of sonographic measurement of ONSD are 5.1 mm and 5.9 mm in healthy Chinese adults. The ONSD is correlated with OND, while independent of gender, age, height, weight and ETD. The median OND/ONSD ratio is 0.63 and this parameter warrants further investigation in patients with brain injury.

No MeSH data available.


Related in: MedlinePlus