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The effect of meditation on regulation of internal body states.

Khalsa SS, Rudrauf D, Davidson RJ, Tranel D - Front Psychol (2015)

Bottom Line: In that study, while meditating, a self-taught meditator exhibited unexpected decreases in heart rate while receiving moderate intravenous doses of the beta adrenergic agonist isoproterenol.This effect was no longer observed when the individual received isoproterenol infusions while not meditating.These results suggest that meditation is not associated with increased regulation of elevated cardiac adrenergic tone.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University of Iowa Iowa City, IA, USA ; Laureate Institute for Brain Research Tulsa, OK, USA ; Faculty of Community Medicine, University of Tulsa Tulsa, OK, USA.

ABSTRACT
Meditation is commonly thought to induce physiologically quiescent states, as evidenced by decreased autonomic parameters during the meditation practice including reduced heart rate, respiratory rate, blood pressure, skin conductance, and increased alpha activity in the electroencephalogram. Preliminary empirical support for this idea was provided in a case report by Dimsdale and Mills (2002), where it was found that meditation seemed to regulate increased levels of cardiovascular arousal induced by bolus isoproterenol infusions. In that study, while meditating, a self-taught meditator exhibited unexpected decreases in heart rate while receiving moderate intravenous doses of the beta adrenergic agonist isoproterenol. This effect was no longer observed when the individual received isoproterenol infusions while not meditating. The current study was designed to explore this phenomenon empirically in a group of formally trained meditators. A total of 15 meditators and 15 non-meditators individually matched on age, sex, and body mass index were recruited. Participants received four series of infusions in a pseudorandomized order: isoproterenol while meditating (or during a relaxation condition for the non-meditators), isoproterenol while resting, saline while meditating (or during a relaxation condition for the non-meditators), and saline while resting. Heart rate was continuously measured throughout all infusions, and several measures of heart rate were derived from the instantaneous cardiac waveform. There was no evidence at the group or individual level suggesting that meditation reduced the cardiovascular response to isoproterenol, across all measures. These results suggest that meditation is not associated with increased regulation of elevated cardiac adrenergic tone.

No MeSH data available.


Related in: MedlinePlus

Epochs used to derive different measures of heart rate. This example shows a typical heart rate response to a 2.0 mcg dose of isoproterenol in a single subject.
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Figure 1: Epochs used to derive different measures of heart rate. This example shows a typical heart rate response to a 2.0 mcg dose of isoproterenol in a single subject.

Mentions: Several measures of heart rate were derived from the instantaneous cardiac waveform. These measures were divided across three epochs of specific relevance to the timeline of heart rate changes induced by isoproterenol (Figure 1). The first epoch consisted of a 30 s interval starting immediately after the onset of each infusion. This reflects a period when bolus isoproterenol induced heart rate changes are unlikely to occur. The second epoch consisted of a 90 s interval beginning 30 s after infusion administration. This reflects a period when bolus isoproterenol induced heart rate changes are most likely to occur. The third epoch consisted of a 60 s period beginning immediately after the end of the second epoch. This interval reflects a period when the heart rate is nearing baseline or has already returned back to baseline. These three epochs combine to represent the 3 min following each infusion onset, when the probability of isoproterenol induced changes in heart rate are maximal. Because the participant could hear the nurse was preparing the next infusion during the final 30 s period (of the 3.5 min separating each infusion), this period was not included in the analysis to remove any potential influence of this preparatory period on the heart rate.


The effect of meditation on regulation of internal body states.

Khalsa SS, Rudrauf D, Davidson RJ, Tranel D - Front Psychol (2015)

Epochs used to derive different measures of heart rate. This example shows a typical heart rate response to a 2.0 mcg dose of isoproterenol in a single subject.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493770&req=5

Figure 1: Epochs used to derive different measures of heart rate. This example shows a typical heart rate response to a 2.0 mcg dose of isoproterenol in a single subject.
Mentions: Several measures of heart rate were derived from the instantaneous cardiac waveform. These measures were divided across three epochs of specific relevance to the timeline of heart rate changes induced by isoproterenol (Figure 1). The first epoch consisted of a 30 s interval starting immediately after the onset of each infusion. This reflects a period when bolus isoproterenol induced heart rate changes are unlikely to occur. The second epoch consisted of a 90 s interval beginning 30 s after infusion administration. This reflects a period when bolus isoproterenol induced heart rate changes are most likely to occur. The third epoch consisted of a 60 s period beginning immediately after the end of the second epoch. This interval reflects a period when the heart rate is nearing baseline or has already returned back to baseline. These three epochs combine to represent the 3 min following each infusion onset, when the probability of isoproterenol induced changes in heart rate are maximal. Because the participant could hear the nurse was preparing the next infusion during the final 30 s period (of the 3.5 min separating each infusion), this period was not included in the analysis to remove any potential influence of this preparatory period on the heart rate.

Bottom Line: In that study, while meditating, a self-taught meditator exhibited unexpected decreases in heart rate while receiving moderate intravenous doses of the beta adrenergic agonist isoproterenol.This effect was no longer observed when the individual received isoproterenol infusions while not meditating.These results suggest that meditation is not associated with increased regulation of elevated cardiac adrenergic tone.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University of Iowa Iowa City, IA, USA ; Laureate Institute for Brain Research Tulsa, OK, USA ; Faculty of Community Medicine, University of Tulsa Tulsa, OK, USA.

ABSTRACT
Meditation is commonly thought to induce physiologically quiescent states, as evidenced by decreased autonomic parameters during the meditation practice including reduced heart rate, respiratory rate, blood pressure, skin conductance, and increased alpha activity in the electroencephalogram. Preliminary empirical support for this idea was provided in a case report by Dimsdale and Mills (2002), where it was found that meditation seemed to regulate increased levels of cardiovascular arousal induced by bolus isoproterenol infusions. In that study, while meditating, a self-taught meditator exhibited unexpected decreases in heart rate while receiving moderate intravenous doses of the beta adrenergic agonist isoproterenol. This effect was no longer observed when the individual received isoproterenol infusions while not meditating. The current study was designed to explore this phenomenon empirically in a group of formally trained meditators. A total of 15 meditators and 15 non-meditators individually matched on age, sex, and body mass index were recruited. Participants received four series of infusions in a pseudorandomized order: isoproterenol while meditating (or during a relaxation condition for the non-meditators), isoproterenol while resting, saline while meditating (or during a relaxation condition for the non-meditators), and saline while resting. Heart rate was continuously measured throughout all infusions, and several measures of heart rate were derived from the instantaneous cardiac waveform. There was no evidence at the group or individual level suggesting that meditation reduced the cardiovascular response to isoproterenol, across all measures. These results suggest that meditation is not associated with increased regulation of elevated cardiac adrenergic tone.

No MeSH data available.


Related in: MedlinePlus