The apéritif effect: Alcohol's effects on the brain's response to food aromas in women.
Bottom Line: This greater food consumption may result from increased activity in brain regions that mediate reward and regulate feeding behavior.Food consumption was significantly greater, and levels of ghrelin were reduced, following alcohol.The hypothalamus may mediate the interplay of alcohol and responses to food cues, thus playing a role in the apéritif phenomenon.
Affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.Show MeSH
Mentions: Linear mixed models (Session [EtOH, Saline] × Time [Pre-Infusion, Post-Infusion]) of plasma glucose, insulin, and ghrelin (analyzed separately) revealed main effects of Time (ps<0.002) for all, with each decreasing when compared to the pre-infusion measurement; with no effect of Time observed for leptin (p=0.83). A significant effect of Session (p<0.001) was present for ghrelin, with alcohol significantly decreasing ghrelin (p<0.001), but not saline (p=0.12; Figure 2). A significant effect of Session was present for leptin (p<0.001); however, post-hoc analysis revealed no significant effect of alcohol infusion (p>0.05).
Affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.