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The apéritif effect: Alcohol's effects on the brain's response to food aromas in women.

Eiler WJ, Džemidžić M, Case KR, Soeurt CM, Armstrong CL, Mattes RD, O'Connor SJ, Harezlak J, Acton AJ, Considine RV, Kareken DA - Obesity (Silver Spring) (2015)

Bottom Line: This greater food consumption may result from increased activity in brain regions that mediate reward and regulate feeding behavior.Food consumption was significantly greater, and levels of ghrelin were reduced, following alcohol.The hypothalamus may mediate the interplay of alcohol and responses to food cues, thus playing a role in the apéritif phenomenon.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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Subjective Effects of Alcohol as reported both pre- and during alcohol and saline infusion sessions. T0 = Pre-Infusion baseline; T1 – T5 = Intra-Infusion assessments. Intensity (FO=12.2, SE=1.0; IEd=12.1, SE=0.9), pleasantness (FO = 7.0±0.2; IEd = 7.6±0.2), and representativeness (FO = 6.8±0.2; IEd = 7.6±0.2) (for details, see Methods).
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Figure 1: Subjective Effects of Alcohol as reported both pre- and during alcohol and saline infusion sessions. T0 = Pre-Infusion baseline; T1 – T5 = Intra-Infusion assessments. Intensity (FO=12.2, SE=1.0; IEd=12.1, SE=0.9), pleasantness (FO = 7.0±0.2; IEd = 7.6±0.2), and representativeness (FO = 6.8±0.2; IEd = 7.6±0.2) (for details, see Methods).

Mentions: As analyzed in a 2 (Session) × 6 (Time) linear mixed model, significant main effects of both Session and Time for perceived intoxication, number of drinks, high, and numbness/tingling (ps<0.001; Figure 1) emerged. As intended, alcohol infusion induced a clear subjective sense of alcohol exposure.


The apéritif effect: Alcohol's effects on the brain's response to food aromas in women.

Eiler WJ, Džemidžić M, Case KR, Soeurt CM, Armstrong CL, Mattes RD, O'Connor SJ, Harezlak J, Acton AJ, Considine RV, Kareken DA - Obesity (Silver Spring) (2015)

Subjective Effects of Alcohol as reported both pre- and during alcohol and saline infusion sessions. T0 = Pre-Infusion baseline; T1 – T5 = Intra-Infusion assessments. Intensity (FO=12.2, SE=1.0; IEd=12.1, SE=0.9), pleasantness (FO = 7.0±0.2; IEd = 7.6±0.2), and representativeness (FO = 6.8±0.2; IEd = 7.6±0.2) (for details, see Methods).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493764&req=5

Figure 1: Subjective Effects of Alcohol as reported both pre- and during alcohol and saline infusion sessions. T0 = Pre-Infusion baseline; T1 – T5 = Intra-Infusion assessments. Intensity (FO=12.2, SE=1.0; IEd=12.1, SE=0.9), pleasantness (FO = 7.0±0.2; IEd = 7.6±0.2), and representativeness (FO = 6.8±0.2; IEd = 7.6±0.2) (for details, see Methods).
Mentions: As analyzed in a 2 (Session) × 6 (Time) linear mixed model, significant main effects of both Session and Time for perceived intoxication, number of drinks, high, and numbness/tingling (ps<0.001; Figure 1) emerged. As intended, alcohol infusion induced a clear subjective sense of alcohol exposure.

Bottom Line: This greater food consumption may result from increased activity in brain regions that mediate reward and regulate feeding behavior.Food consumption was significantly greater, and levels of ghrelin were reduced, following alcohol.The hypothalamus may mediate the interplay of alcohol and responses to food cues, thus playing a role in the apéritif phenomenon.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Show MeSH