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Imaging neuroinflammation? A perspective from MR spectroscopy.

Zahr NM, Mayer D, Rohlfing T, Sullivan EV, Pfefferbaum A - Brain Pathol. (2014)

Bottom Line: Significant four-group comparisons were evident only for striatal choline-containing compounds (Cho) and myo-inositol (mI), which follow-up analysis demonstrated were due to higher levels in HA compared with C individuals.Higher levels of mI were related to greater lifetime alcohol consumed, whereas HAART was associated with lower mI levels.The current results suggest that competing mechanisms can influence in vivo Cho and mI levels, and that elevations in these metabolites cannot necessarily be interpreted as reflecting a single underlying mechanism, including neuroinflammation.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine (MC5723), Stanford, CA; Neuroscience Program, SRI International, Menlo Park, CA.

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Related in: MedlinePlus

Striatal, cerebellar and pontine mI levels in H + HA individuals grouped by total lifetime alcohol consumed and medication status (HAART, yes/no). a.u. = arbitrary units; H = human immunodeficiency virus (HIV) positive; HA = HIV positive + alcoholic individuals; HAART = highly active antiretroviral HIV treatment; mI = myo-inositol; a.u. = arbitrary units.
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fig04: Striatal, cerebellar and pontine mI levels in H + HA individuals grouped by total lifetime alcohol consumed and medication status (HAART, yes/no). a.u. = arbitrary units; H = human immunodeficiency virus (HIV) positive; HA = HIV positive + alcoholic individuals; HAART = highly active antiretroviral HIV treatment; mI = myo-inositol; a.u. = arbitrary units.

Mentions: Examination of all potentially contributing factors to the variance in striatal mI showed that total lifetime alcohol consumed was associated with higher mI (r = 0.28, P = 0.0230; ρ = 0.24, P = 0.0493), whereas being on HAART medication was associated with lower striatal mI levels [t(65) = 1.9, P = 0.0573; χ2 = 4.2, P = 0.0395] (Figure 4).


Imaging neuroinflammation? A perspective from MR spectroscopy.

Zahr NM, Mayer D, Rohlfing T, Sullivan EV, Pfefferbaum A - Brain Pathol. (2014)

Striatal, cerebellar and pontine mI levels in H + HA individuals grouped by total lifetime alcohol consumed and medication status (HAART, yes/no). a.u. = arbitrary units; H = human immunodeficiency virus (HIV) positive; HA = HIV positive + alcoholic individuals; HAART = highly active antiretroviral HIV treatment; mI = myo-inositol; a.u. = arbitrary units.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493672&req=5

fig04: Striatal, cerebellar and pontine mI levels in H + HA individuals grouped by total lifetime alcohol consumed and medication status (HAART, yes/no). a.u. = arbitrary units; H = human immunodeficiency virus (HIV) positive; HA = HIV positive + alcoholic individuals; HAART = highly active antiretroviral HIV treatment; mI = myo-inositol; a.u. = arbitrary units.
Mentions: Examination of all potentially contributing factors to the variance in striatal mI showed that total lifetime alcohol consumed was associated with higher mI (r = 0.28, P = 0.0230; ρ = 0.24, P = 0.0493), whereas being on HAART medication was associated with lower striatal mI levels [t(65) = 1.9, P = 0.0573; χ2 = 4.2, P = 0.0395] (Figure 4).

Bottom Line: Significant four-group comparisons were evident only for striatal choline-containing compounds (Cho) and myo-inositol (mI), which follow-up analysis demonstrated were due to higher levels in HA compared with C individuals.Higher levels of mI were related to greater lifetime alcohol consumed, whereas HAART was associated with lower mI levels.The current results suggest that competing mechanisms can influence in vivo Cho and mI levels, and that elevations in these metabolites cannot necessarily be interpreted as reflecting a single underlying mechanism, including neuroinflammation.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine (MC5723), Stanford, CA; Neuroscience Program, SRI International, Menlo Park, CA.

Show MeSH
Related in: MedlinePlus