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The Effect of Low Molecular Weight Heparins on Fracture Healing.

Kapetanakis S, Nastoulis E, Demesticha T, Demetriou T - Open Orthop J (2015)

Bottom Line: The prolonged use of unfractionated heparin has been connected with increased incidence of osteoporotic fractures.Low molecular-weight-heparins (LMWHs) have been the golden rule in antithrombotic therapy during the previous two decades as a way to overcome the major drawbacks of unfractioned heparin.The authors' research based on literature concluded that there are no facts and statistics for the role of LMWHs on fracture healing process in humans and the main body of evidence of their role comes from in vitro and animal studies.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

ABSTRACT
Venous Thromboembolism is a serious complication in the trauma patient. The most commonly studied and used anticoagulant treatment in prophylaxis of thrombosis is heparin. The prolonged use of unfractionated heparin has been connected with increased incidence of osteoporotic fractures. Low molecular-weight-heparins (LMWHs) have been the golden rule in antithrombotic therapy during the previous two decades as a way to overcome the major drawbacks of unfractioned heparin. However there are few studies reporting the effects of LMWHs on bone repair after fractures. This review presents the studies about the effects of LMWHs on bone biology (bone cells and bone metabolism) and underlying the mechanisms by which LMWHs may impair fracture healing process. The authors' research based on literature concluded that there are no facts and statistics for the role of LMWHs on fracture healing process in humans and the main body of evidence of their role comes from in vitro and animal studies. Further large clinical studies designed to compare different types of LMWHs, in different dosages and in different patient or animal models are needed for exploring the effects of LMWHs on fracture healing process.

No MeSH data available.


Related in: MedlinePlus

Bone formation (callus) after Low Molecular heparin therapy in rabbits. Undecalcified histological sections (a, b) of a critical-sized defect treated (a) with heparin (b) without heparin 2 months after the fracture. (HxE, magnification X100) NB: new bone, MC: medullary cavities, C: cartilage.
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Figure 1: Bone formation (callus) after Low Molecular heparin therapy in rabbits. Undecalcified histological sections (a, b) of a critical-sized defect treated (a) with heparin (b) without heparin 2 months after the fracture. (HxE, magnification X100) NB: new bone, MC: medullary cavities, C: cartilage.

Mentions: This review presents the studies about the effects of the LMWHs on bone biology (bone cells and bone metabolism) and highlights the underlying mechanisms by which LMWHs may impair fracture healing (Fig. 1a, b).


The Effect of Low Molecular Weight Heparins on Fracture Healing.

Kapetanakis S, Nastoulis E, Demesticha T, Demetriou T - Open Orthop J (2015)

Bone formation (callus) after Low Molecular heparin therapy in rabbits. Undecalcified histological sections (a, b) of a critical-sized defect treated (a) with heparin (b) without heparin 2 months after the fracture. (HxE, magnification X100) NB: new bone, MC: medullary cavities, C: cartilage.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493651&req=5

Figure 1: Bone formation (callus) after Low Molecular heparin therapy in rabbits. Undecalcified histological sections (a, b) of a critical-sized defect treated (a) with heparin (b) without heparin 2 months after the fracture. (HxE, magnification X100) NB: new bone, MC: medullary cavities, C: cartilage.
Mentions: This review presents the studies about the effects of the LMWHs on bone biology (bone cells and bone metabolism) and highlights the underlying mechanisms by which LMWHs may impair fracture healing (Fig. 1a, b).

Bottom Line: The prolonged use of unfractionated heparin has been connected with increased incidence of osteoporotic fractures.Low molecular-weight-heparins (LMWHs) have been the golden rule in antithrombotic therapy during the previous two decades as a way to overcome the major drawbacks of unfractioned heparin.The authors' research based on literature concluded that there are no facts and statistics for the role of LMWHs on fracture healing process in humans and the main body of evidence of their role comes from in vitro and animal studies.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

ABSTRACT
Venous Thromboembolism is a serious complication in the trauma patient. The most commonly studied and used anticoagulant treatment in prophylaxis of thrombosis is heparin. The prolonged use of unfractionated heparin has been connected with increased incidence of osteoporotic fractures. Low molecular-weight-heparins (LMWHs) have been the golden rule in antithrombotic therapy during the previous two decades as a way to overcome the major drawbacks of unfractioned heparin. However there are few studies reporting the effects of LMWHs on bone repair after fractures. This review presents the studies about the effects of LMWHs on bone biology (bone cells and bone metabolism) and underlying the mechanisms by which LMWHs may impair fracture healing process. The authors' research based on literature concluded that there are no facts and statistics for the role of LMWHs on fracture healing process in humans and the main body of evidence of their role comes from in vitro and animal studies. Further large clinical studies designed to compare different types of LMWHs, in different dosages and in different patient or animal models are needed for exploring the effects of LMWHs on fracture healing process.

No MeSH data available.


Related in: MedlinePlus