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Mice that gorged during dietary restriction increased foraging related behaviors and differed in their macronutrient preference when released from restriction.

Hambly C, Speakman JR - PeerJ (2015)

Bottom Line: Gorgers lost significantly more BM than non-gorgers possibly due to an increased physical activity linked to anticipation of daily food provision.Gorgers and non-gorgers had a significantly greater high carbohydrate diet intake than controls, and gorgers also had a significantly greater high protein diet intake than non-gorgers and controls.On unrestricted food, they did not continue to gorge, although they still had a significantly greater 2-h FI than the other groups.

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Affiliation: Institute of Biological and Environmental Sciences, University of Aberdeen , Aberdeen , UK.

ABSTRACT
Caloric restriction (CR) can trigger gorging behavior. We examined macronutrient choice and behavior in mice that gorged during restriction compared to restricted non-gorgers and controls. Fifty MF1 male mice were restricted to 75% of ad-libitum food intake (FI), while ten controls were fed ad-lib. Body mass (BM) and FI were measured two and 24-h after food inclusion over 14-days. 'Gorging' mice were defined as those which ate over 25% of their daily FI in 2-h. The top 11 gorgers and the lowest 9 gorgers, along with 10 controls, had their behavior analysed during restriction, and were then provided with an unrestricted food choice, consisting of three diets that were high in fat, protein or carbohydrate. During restriction gorgers ate on average 51% of their daily FI in the 2-h following food introduction while the non-gorgers ate only 16%. Gorgers lost significantly more BM than non-gorgers possibly due to an increased physical activity linked to anticipation of daily food provision. Controls and non-gorgers spent most of their time sleeping. After restriction, both gorgers and non-gorgers were hyperphagic until their lost weight was regained. All 3 groups favoured high fat food. Gorgers and non-gorgers had a significantly greater high carbohydrate diet intake than controls, and gorgers also had a significantly greater high protein diet intake than non-gorgers and controls. On unrestricted food, they did not continue to gorge, although they still had a significantly greater 2-h FI than the other groups. Elevated protein intake may play an important role in the recovery of the lost lean tissue of gorgers after restriction.

No MeSH data available.


Mean energy assimilated (kJ/day) over a 24-h period for the three groups.The diet choice period is the combined assimilation for high fat, protein and carbohydrate diets. Standard error bars are shown.
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fig-4: Mean energy assimilated (kJ/day) over a 24-h period for the three groups.The diet choice period is the combined assimilation for high fat, protein and carbohydrate diets. Standard error bars are shown.

Mentions: After providing all three groups with a choice of diets high in fat, carbohydrate and protein, the controls daily food intake significantly decreased so that over the last 5 days of measurements it was 3.8 ± 0.13 g which was 2.1 g less than just prior to diet choice provision (Table 2). They ate some of all three diets and although the energy value for each diet was greater than the previously fed chow (Table 1), the energy intake calculated from the total dietary intake was reduced by 31.2 kJ/day (or 26.9% lower) than prior to providing the diet choice. This difference was significant (Paired T-test T = 5.50, P < 0.001). They managed, however, to maintain a similar rate of body mass increase even with the reduced energy intake. This is because there were increases in digestive efficiency on the 3 diets compared to the standard chow (Table 1 previously measured by J Kagya-Agyeman, 2009, unpublished data) which meant that the energy assimilated was not significantly different from the baseline period (Paired t-test T = 1.19, P = 0.26) (Fig. 4).


Mice that gorged during dietary restriction increased foraging related behaviors and differed in their macronutrient preference when released from restriction.

Hambly C, Speakman JR - PeerJ (2015)

Mean energy assimilated (kJ/day) over a 24-h period for the three groups.The diet choice period is the combined assimilation for high fat, protein and carbohydrate diets. Standard error bars are shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493644&req=5

fig-4: Mean energy assimilated (kJ/day) over a 24-h period for the three groups.The diet choice period is the combined assimilation for high fat, protein and carbohydrate diets. Standard error bars are shown.
Mentions: After providing all three groups with a choice of diets high in fat, carbohydrate and protein, the controls daily food intake significantly decreased so that over the last 5 days of measurements it was 3.8 ± 0.13 g which was 2.1 g less than just prior to diet choice provision (Table 2). They ate some of all three diets and although the energy value for each diet was greater than the previously fed chow (Table 1), the energy intake calculated from the total dietary intake was reduced by 31.2 kJ/day (or 26.9% lower) than prior to providing the diet choice. This difference was significant (Paired T-test T = 5.50, P < 0.001). They managed, however, to maintain a similar rate of body mass increase even with the reduced energy intake. This is because there were increases in digestive efficiency on the 3 diets compared to the standard chow (Table 1 previously measured by J Kagya-Agyeman, 2009, unpublished data) which meant that the energy assimilated was not significantly different from the baseline period (Paired t-test T = 1.19, P = 0.26) (Fig. 4).

Bottom Line: Gorgers lost significantly more BM than non-gorgers possibly due to an increased physical activity linked to anticipation of daily food provision.Gorgers and non-gorgers had a significantly greater high carbohydrate diet intake than controls, and gorgers also had a significantly greater high protein diet intake than non-gorgers and controls.On unrestricted food, they did not continue to gorge, although they still had a significantly greater 2-h FI than the other groups.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Biological and Environmental Sciences, University of Aberdeen , Aberdeen , UK.

ABSTRACT
Caloric restriction (CR) can trigger gorging behavior. We examined macronutrient choice and behavior in mice that gorged during restriction compared to restricted non-gorgers and controls. Fifty MF1 male mice were restricted to 75% of ad-libitum food intake (FI), while ten controls were fed ad-lib. Body mass (BM) and FI were measured two and 24-h after food inclusion over 14-days. 'Gorging' mice were defined as those which ate over 25% of their daily FI in 2-h. The top 11 gorgers and the lowest 9 gorgers, along with 10 controls, had their behavior analysed during restriction, and were then provided with an unrestricted food choice, consisting of three diets that were high in fat, protein or carbohydrate. During restriction gorgers ate on average 51% of their daily FI in the 2-h following food introduction while the non-gorgers ate only 16%. Gorgers lost significantly more BM than non-gorgers possibly due to an increased physical activity linked to anticipation of daily food provision. Controls and non-gorgers spent most of their time sleeping. After restriction, both gorgers and non-gorgers were hyperphagic until their lost weight was regained. All 3 groups favoured high fat food. Gorgers and non-gorgers had a significantly greater high carbohydrate diet intake than controls, and gorgers also had a significantly greater high protein diet intake than non-gorgers and controls. On unrestricted food, they did not continue to gorge, although they still had a significantly greater 2-h FI than the other groups. Elevated protein intake may play an important role in the recovery of the lost lean tissue of gorgers after restriction.

No MeSH data available.