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Mice that gorged during dietary restriction increased foraging related behaviors and differed in their macronutrient preference when released from restriction.

Hambly C, Speakman JR - PeerJ (2015)

Bottom Line: Gorgers lost significantly more BM than non-gorgers possibly due to an increased physical activity linked to anticipation of daily food provision.Gorgers and non-gorgers had a significantly greater high carbohydrate diet intake than controls, and gorgers also had a significantly greater high protein diet intake than non-gorgers and controls.On unrestricted food, they did not continue to gorge, although they still had a significantly greater 2-h FI than the other groups.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Biological and Environmental Sciences, University of Aberdeen , Aberdeen , UK.

ABSTRACT
Caloric restriction (CR) can trigger gorging behavior. We examined macronutrient choice and behavior in mice that gorged during restriction compared to restricted non-gorgers and controls. Fifty MF1 male mice were restricted to 75% of ad-libitum food intake (FI), while ten controls were fed ad-lib. Body mass (BM) and FI were measured two and 24-h after food inclusion over 14-days. 'Gorging' mice were defined as those which ate over 25% of their daily FI in 2-h. The top 11 gorgers and the lowest 9 gorgers, along with 10 controls, had their behavior analysed during restriction, and were then provided with an unrestricted food choice, consisting of three diets that were high in fat, protein or carbohydrate. During restriction gorgers ate on average 51% of their daily FI in the 2-h following food introduction while the non-gorgers ate only 16%. Gorgers lost significantly more BM than non-gorgers possibly due to an increased physical activity linked to anticipation of daily food provision. Controls and non-gorgers spent most of their time sleeping. After restriction, both gorgers and non-gorgers were hyperphagic until their lost weight was regained. All 3 groups favoured high fat food. Gorgers and non-gorgers had a significantly greater high carbohydrate diet intake than controls, and gorgers also had a significantly greater high protein diet intake than non-gorgers and controls. On unrestricted food, they did not continue to gorge, although they still had a significantly greater 2-h FI than the other groups. Elevated protein intake may play an important role in the recovery of the lost lean tissue of gorgers after restriction.

No MeSH data available.


Change in body mass (g) from initial mass on day one of baseline over the course of baseline, restriction and diet choice.Standard error bars are shown.
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fig-3: Change in body mass (g) from initial mass on day one of baseline over the course of baseline, restriction and diet choice.Standard error bars are shown.

Mentions: To compare body mass of the three groups for each phase, the last five days were averaged for all animals in each group. Gorgers and non-gorgers both significantly decreased their body mass during restriction by an average of 3.3 g and 1.2 g respectively (Paired t-test P < 0.001). The decrease in body mass observed in the gorgers compared to their baseline value was significantly greater than the non-gorgers (9.6% compared to 3.4%). The controls significantly increased their body mass over the same time period by 1.6 g (4.4%) (Paired t-test P < 0.01) (Fig. 3). Over the last 5 days of restriction the gorgers were still losing weight at a rate of 0.22 ± 0.04 g/day while the non-gorgers had stabilised their body mass as the average rate of weight loss was only 0.04 ± 0.05 g/day showing that they had almost reached energy balance. In contrast the controls were gaining weight at 0.14 ± 0.04 g/day. These values were significantly different between the 3 groups (ANOVA F2,27 = 14.7, P < 0.001).


Mice that gorged during dietary restriction increased foraging related behaviors and differed in their macronutrient preference when released from restriction.

Hambly C, Speakman JR - PeerJ (2015)

Change in body mass (g) from initial mass on day one of baseline over the course of baseline, restriction and diet choice.Standard error bars are shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493644&req=5

fig-3: Change in body mass (g) from initial mass on day one of baseline over the course of baseline, restriction and diet choice.Standard error bars are shown.
Mentions: To compare body mass of the three groups for each phase, the last five days were averaged for all animals in each group. Gorgers and non-gorgers both significantly decreased their body mass during restriction by an average of 3.3 g and 1.2 g respectively (Paired t-test P < 0.001). The decrease in body mass observed in the gorgers compared to their baseline value was significantly greater than the non-gorgers (9.6% compared to 3.4%). The controls significantly increased their body mass over the same time period by 1.6 g (4.4%) (Paired t-test P < 0.01) (Fig. 3). Over the last 5 days of restriction the gorgers were still losing weight at a rate of 0.22 ± 0.04 g/day while the non-gorgers had stabilised their body mass as the average rate of weight loss was only 0.04 ± 0.05 g/day showing that they had almost reached energy balance. In contrast the controls were gaining weight at 0.14 ± 0.04 g/day. These values were significantly different between the 3 groups (ANOVA F2,27 = 14.7, P < 0.001).

Bottom Line: Gorgers lost significantly more BM than non-gorgers possibly due to an increased physical activity linked to anticipation of daily food provision.Gorgers and non-gorgers had a significantly greater high carbohydrate diet intake than controls, and gorgers also had a significantly greater high protein diet intake than non-gorgers and controls.On unrestricted food, they did not continue to gorge, although they still had a significantly greater 2-h FI than the other groups.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Biological and Environmental Sciences, University of Aberdeen , Aberdeen , UK.

ABSTRACT
Caloric restriction (CR) can trigger gorging behavior. We examined macronutrient choice and behavior in mice that gorged during restriction compared to restricted non-gorgers and controls. Fifty MF1 male mice were restricted to 75% of ad-libitum food intake (FI), while ten controls were fed ad-lib. Body mass (BM) and FI were measured two and 24-h after food inclusion over 14-days. 'Gorging' mice were defined as those which ate over 25% of their daily FI in 2-h. The top 11 gorgers and the lowest 9 gorgers, along with 10 controls, had their behavior analysed during restriction, and were then provided with an unrestricted food choice, consisting of three diets that were high in fat, protein or carbohydrate. During restriction gorgers ate on average 51% of their daily FI in the 2-h following food introduction while the non-gorgers ate only 16%. Gorgers lost significantly more BM than non-gorgers possibly due to an increased physical activity linked to anticipation of daily food provision. Controls and non-gorgers spent most of their time sleeping. After restriction, both gorgers and non-gorgers were hyperphagic until their lost weight was regained. All 3 groups favoured high fat food. Gorgers and non-gorgers had a significantly greater high carbohydrate diet intake than controls, and gorgers also had a significantly greater high protein diet intake than non-gorgers and controls. On unrestricted food, they did not continue to gorge, although they still had a significantly greater 2-h FI than the other groups. Elevated protein intake may play an important role in the recovery of the lost lean tissue of gorgers after restriction.

No MeSH data available.